5-(2-Fluorophenyl)-1H-Pyrrole-3-Carbaldehyde CAS 881674-56-2 Vonoprazan Fumarate Kemurnian Menengah ≥99,0%
Suplai Vonoprazan Fumarate lan Related Intermediate
5-(2-Fluorophenyl)pirol-3-Carboxaldehyde CAS 881674-56-2
Piridin-3-Sulfonil Klorida CAS 16133-25-8
Vonoprazan Fumarate (TAK-438) CAS 1260141-27-2 881681-01-2
| Jeneng Kimia | 5-(2-Fluorophenyl)-1H-Pyrrole-3-Carbaldehyde |
| sinonim | Vonoprazan Fumarate (TAK-438) Intermediate 3 |
| Nomer CAS | 881674-56-2 |
| Nomer CAT | RF-PI330 |
| Status Simpenan | Ing Simpenan, Skala Produksi Nganti Ton |
| Formula Molekul | C11H8FNO |
| Bobot Molekul | 189.19 |
| Merk | Kimia Ruifu |
| Item | Spesifikasi |
| Penampilan | Bubuk kuning nganti coklat |
| Titik Lebur | 122.0~131.0 ℃ |
| Identifikasi: RT(HPLC) | Selaras karo Standar Referensi |
| Mundhut Ing Pangatusan | ≤0,50% |
| Sisa Ing Ignition | ≤0,50% |
| Zat sing gegandhengan | |
| Kemurnian | ≥99,0% |
| Sembarang Impurity Single | ≤0,50% |
| Total Impurities | ≤1,0% |
| Standar Tes | Standar Perusahaan |
| Panggunaan | Penengah Vonoprazan Fumarate (TAK-438) (CAS 881681-01-2) |
Paket: Botol, tas Aluminium foil, Drum karton, 25kg / Drum, utawa miturut kabutuhan pelanggan.
Kondisi panyimpenan:Simpen ing wadhah sing disegel ing papan sing adhem lan garing;Nglindhungi saka cahya, kelembapan lan infestasi hama.
5-(2-Fluorophenyl)-1H-Pyrrole-3-Carbaldehyde (CAS 881674-56-2) tumindak minangka reagen ing persiapan sintetik saka turunan pirol novel minangka blocker asam kompetitif kalium (P-CAB).5-(2-Fluorophenyl)pyrrole-3-Carboxaldehyde minangka perantara saka Vonoprazan Fumarate (CAS 1260141-27-2).Vonoprazan fumarate (Takecab®), sing ditemokake lan dikembangake dening Takeda lan Otsuka, disetujoni dening PMDA Jepang ing Desember 2014, lan dituduhake kanggo perawatan ulkus lambung, ulkus duodenum lan esofagitis refluks.Vonoprazan fumarate nduweni mekanisme aksi anyar sing disebut blocker asam kompetitif kalium, sing kanthi kompetitif nyandhet ikatan ion kalium menyang H+, K+-ATPase (uga dikenal minangka pompa proton) ing tahap pungkasan sekresi asam lambung ing sel parietal lambung.Vonoprazan ora nyandhet aktivitas Na +, K + -ATPase sanajan ing konsentrasi 500 kaping luwih dhuwur tinimbang nilai IC50 marang aktivitas H +, K + -ATPase lambung.Salajengipun, obat kasebut ora kena pengaruh negara secretory lambung, ora kaya PPI.
