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7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one CAS 160129-45-3 Tolvaptan Intermediate
Pasokan Produsen, Kualitas Tinggi, Produksi Komersial
Tolvaptan lan perantara sing gegandhengan:
Tolvaptan CAS 150683-30-0
7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one CAS 160129-45-3
o-Toluoyl Klorida CAS 933-88-0
4-Amino-2-Asam Metilbenzoat CAS 2486-75-1
2-Metil-4-Asam Nitrobenzoat CAS 1975-51-5
| Jeneng Kimia | 7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-siji |
| sinonim | 7-Chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-siji;7-Chloro-3,4-dihydro-1H-benzo[b]azepin-5(2H)-siji |
| Nomer CAS | 160129-45-3 |
| Nomer CAT | RF-PI395 |
| Status Simpenan | Ing Simpenan, Skala Produksi Nganti Ton |
| Formula Molekul | C10H10ClNO |
| Bobot Molekul | 195.65 |
| Titik Lebur | 103,0 kanggo 107,0 ℃ |
| Kelarutan | Larut ing Metanol |
| Merk | Kimia Ruifu |
| Item | Spesifikasi |
| Penampilan | Ijo cahya nganti bubuk kuning cahya |
| Metode Identifikasi | NMR, HPLC |
| Kemurnian / Metode Analisis | ≥99,0% (HPLC) |
| Mundhut ing Pangatusan | ≤1,0% |
| Sisa ing Ignition | ≤0,50% |
| Sembarang Impurity Single | ≤0,50% |
| Total Impurities | ≤1,0% |
| Standar Tes | Standar Perusahaan |
| Panggunaan | Intermediate of Tolvaptan (CAS 150683-30-0), perawatan saka Hyponatremia |
Paket: Botol, tas Aluminium foil, 25kg / Drum Karton, utawa miturut kabutuhan pelanggan.
Kondisi panyimpenan:Simpen ing wadhah sing disegel ing papan sing adhem lan garing;Nglindhungi saka cahya lan Kelembapan.
7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one (CAS 160129-45-3) minangka perantara ing sintesis Tolvaptan (CAS 150683-30-0).Tolvaptan minangka antagonis reseptor arginin vasopressin V2 nonpeptida aktif nonpeptida aktif kanthi IC50 kanthi IC50 1.28µM kanggo nyegah agregasi platelet sing diakibatake AVP.Tolvaptan digunakake kanggo nambani hyponatremia sing gegandhèngan karo gagal jantung kongestif, sirosis, lan sindrom hormon antidiuretik sing ora cocog.Tolvaptan uga ana ing uji klinis kanthi cepet kanggo penyakit ginjel polikistik.Perawatan karo Tolvaptan nyebabake nyuda bobot awak kanthi cepet lan terus-terusan bebarengan karo mundhake output urin, nambah lan / utawa normalake sodium serum ing pasien hyponatremic, nyuda pratandha lan gejala kemacetan lan nambah rasa ngelak.
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