7-Fluoro-6-Nitroquinazolin-4(1H)-siji CAS 162012-69-3 Kemurnian >99,0% (HPLC) Afatinib Dimaleate Intermediate Factory

Katrangan singkat:

Jeneng Kimia: 7-Fluoro-6-Nitroquinazolin-4(1H)-siji

CAS: 162012-69-3

Kemurnian: >99,0% (HPLC)

Kuning nganti Reddish Kuning Crystal utawa Powder

Penengah saka Afatinib Dimaleate (CAS: 850140-73-7)

Kualitas Tinggi, Produksi Komersial

E-Mail: alvin@ruifuchem.com

Kirimi email kanggo kita

Detail Produk

Produk sing gegandhengan

Tag produk

katrangan:

Ruifu Chemical Supply Intermediates saka Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
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(Dimethylamino)acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Asam Dietilphosphonoacetic CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-siji CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineCAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineCAS 314771-88-5

Sifat Kimia:

Jeneng Kimia	7-Fluoro-6-Nitroquinazolin-4(1H)-siji
sinonim	7-Fluoro-6-Nitroquinazolin-4(3H) -siji;7-Fluoro-4-Hydroxy-6-Nitroquinazoline;7-Fluoro-6-Nitroquinazolin-4-ol;7-Fluoro-6-Nitro-4-Hydroxyquinazoline;7-Fluoro-6-Nitro-1H-Quinazolin-4-siji
Nomer CAS	162012-69-3
Nomer CAT	RF-PI2025
Status Simpenan	Ing Simpenan, Skala Produksi Nganti Ton
Formula Molekul	C8H4FN3O3
Bobot Molekul	209.13
Merk	Kimia Ruifu

Spesifikasi:

Item	Spesifikasi
Penampilan	Kuning nganti Reddish Kuning Crystal utawa Powder
1 H NMR Spektrum	Konsisten karo Struktur
Kemurnian / Metode Analisis	> 99,0% (HPLC)
Mundhut ing Pangatusan	<0,50%
Total Impurities	<1.00%
Proton NMR Spectrum	Conforms kanggo Struktur
Test Standar	Standar Perusahaan
Panggunaan	Penengah saka Afatinib Dimaleate (CAS: 850140-73-7)

Paket & Panyimpenan:

Paket: Botol, tas Aluminium foil, 25kg / Karton Drum, utawa miturut kabutuhan pelanggan

Kondisi panyimpenan:Simpen ing wadhah sing disegel ing papan sing adhem lan garing;Nglindhungi saka cahya lan Kelembapan

Kaluwihan:

FAQ:

Aplikasi:

7-Fluoro-6-Nitroquinazolin-4 (1H) -siji (CAS: 162012-69-3) minangka penengah saka Afatinib Dimaleate (CAS: 850140-73-7).Afatinib minangka kulawarga blocker ErbB sing ora bisa dibatalake sing nyegah transmisi informasi lan ngalangi jalur utama sing ana ing pertumbuhan lan divisi sel kanker.Amarga mekanisme transduksi informasi kulawarga ErbB bisa dipicu dening pirang-pirang homodimer lan heterodimer, inhibisi simultan saka sawetara anggota kulawarga ErbB (kayata EGFR, HER2, ErbB3 lan ErbB4) bisa kanthi efektif ngganggu transduksi informasi hilir.Afatinib minangka obat sing disetujoni kanggo perawatan karsinoma paru-paru non-sel cilik (NSCLC), sing dikembangake dening Boehringer Ingelheim.Iku tumindak minangka inhibitor angiokinase.Kaya lapatinib lan neratinib, afatinib minangka inhibitor tyrosine kinase (TKI) sing uga nyegah reseptor faktor pertumbuhan epidermis manungsa 2 (Her2) lan reseptor faktor pertumbuhan epidermal (EGFR) kinase.Afatinib ora mung aktif nglawan mutasi EGFR sing ditargetake dening TKI generasi pertama likeerlotinib utawa gefitinib, nanging uga marang sing ora sensitif marang terapi standar kasebut.Amarga aktivitas tambahan marang Her2, lagi diselidiki kanggo kanker payudara uga kanker EGFR lan Her2 liyane.