Afatinib Dimaleate Intermediate CAS 314771-76-1 Kemurnian >99,0% (HPLC) Gambar Unggulan Pabrik

Afatinib Dimaleate Intermediate CAS 314771-76-1 Kemurnian >99,0% (HPLC) Pabrik

Katrangan singkat:

Jeneng Kimia: (S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-Diamine

CAS: 314771-76-1

Kemurnian: >99,0% (HPLC)

Penampilan: Kuning cahya nganti bubuk kuning

Penengah saka Afatinib Dimaleate (CAS: 850140-73-7)

E-Mail: alvin@ruifuchem.com

Kirimi email kanggo kita

Detail Produk

Produk sing gegandhengan

Tag produk

katrangan:

Ruifu Chemical Supply Intermediates saka Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino)acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Asam Dietilphosphonoacetic CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-siji CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineCAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineCAS 314771-88-5

Sifat Kimia:

Jeneng Kimia	(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-Diamine
sinonim	N4-(3-Chloro-4-Fluorophenyl)-7-[[(3S)-Tetrahydro-3-Furanyl]oxy] -4,6-Quinazolinediamine;Afatinib Impurity B;Afatinib-des(4-Dimethylamino-2-en-1-oxo)butil;Des(4-Dimethylamino-2-en-1-oxo)butil Afatinib
Nomer CAS	314771-76-1
Nomer CAT	RF-PI2028
Status Simpenan	Ing Simpenan, Kapasitas Produksi 100MT / Taun
Formula Molekul	C18H16ClFN4O2
Bobot Molekul	374.8
Titik didih	559,0 ± 50,0 ℃
Kapadhetan	1,473±0,060 g/cm3
Merk	Kimia Ruifu

Spesifikasi:

Item	Spesifikasi
Penampilan	Cahya Kuning nganti Bubuk Kuning
Identifikasi	Wektu Retensi Puncak Utama ing HPLC Kudu Sesuai karo Standar
Kemurnian / Metode Analisis	> 99,0% (HPLC)
Mundhut ing Pangatusan	<0,50%
Sisa ing Ignition	<0,20%
Impurity Tunggal	<0,50%
Total Impurities	<1.00%
Logam Berat (Pb)	≤20ppm
Test Standar	Standar Perusahaan
Panggunaan	Penengah saka Afatinib Dimaleate (CAS: 850140-73-7)

Paket & Panyimpenan:

Paket: Botol, tas Aluminium foil, 25kg / Karton Drum, utawa miturut kabutuhan pelanggan

Kondisi panyimpenan:Simpen ing wadhah sing disegel ing papan sing adhem lan garing;Nglindhungi saka cahya lan Kelembapan

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Aplikasi:

(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-Diamine (CAS: 314771-76-1) minangka perantara saka Afatinib Dimaleate (CAS: 850140-73-7).Afatinib minangka inhibitor ganda sing kuat lan ora bisa dibatalake saka reseptor faktor pertumbuhan epidermis (EGFR) lan reseptor faktor pertumbuhan epidermis manungsa 2 (HER2) tyrosine kinase, dikembangake dening Boehringer Ingelheim, Jerman.Iki bisa nyegah aktivitas tyrosine kinase kanthi ora bisa dibatalake kanthi ngalami reaksi Michael karo gugus tiol sistein ing posisi 797 EGFR.Fungsi: 1. Kaya Lapatinib lan Neratinib, Afatinib minangka inhibitor protein kinase sing uga nyegah reseptor faktor pertumbuhan epidermis manungsa 2 (Her2) lan reseptor faktor pertumbuhan epidermal (EGFR) kinase.2. Afatinib ora mung aktif nglawan mutasi EGFR sing ditargetake dening TKI generasi pertama kaya erlotinib utawa gefitinib, nanging uga nglawan mutasi kayata T790M sing ora sensitif marang terapi standar kasebut.Amarga aktivitas tambahan marang Her2, lagi diselidiki kanggo kanker payudara uga kanker EGFR lan Her2 liyane.3. Afatinib minangka obat kanggo perawatan lini pertama pasien kanthi jinis metastatik (mutasi EGFR positif) karsinoma paru-paru sel non-cilik (NSCLC) sing béda.Tumindak minangka inhibitor kovalen sing ora bisa dibatalake saka reseptor tyrosine kinase epidermal growth factor receptor (EGFR) lan erbB-2 (HER2).