Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-Butyric Acid CAS 486460-00-8 Kemurnian ≥99,5% (HPLC) Sitagliptin Phosphate Monohydrate Intermediate
Pasokan Sitagliptin Phosphate Monohydrate Related Intermediate:
Sitagliptin API CAS 486460-32-6
Sitagliptin Phosphate Monohydrate API CAS 654671-77-9
2,4,5-Asam Trifluorofenilasetat CAS 209995-38-0
Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-Butyric Acid CAS 486460-00-8
Sitagliptin Triazole Hydrochloride CAS 762240-92-6
Sitagliptin Phosphate Monohydrate Intermediate CAS 486460-21-3
Jeneng Kimia | Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Fenyl)-Butyric Acid |
sinonim | (R)-Sitagliptin N-Boc-Acid Impurity |
Nomer CAS | 486460-00-8 |
Nomer CAT | RF-PI1192 |
Status Simpenan | Ing Simpenan, Skala Produksi Nganti Ton |
Formula Molekul | C15H18F3NO4 |
Bobot Molekul | 333.31 |
Titik Lebur | 136,0 ~ 138,0 ℃ |
Merk | Kimia Ruifu |
Item | Spesifikasi |
Penampilan | Bubuk Putih nganti Putih |
Identifikasi dening HPLC | Wektu Retensi Sampel cocog karo Standar Referensi |
Mundhut ing Pangatusan | ≤0,50% |
Awu sulfat | ≤0,50% |
Logam abot | <20 ppm |
Isomer | ≤0,50% |
Zat sing gegandhengan | |
Najis A | ≤0,50% |
Sembarang Impurity Single Liyane | ≤0,50% |
Total Impurities | ≤0,50% |
Kemurnian | ≥99,5% (HPLC) |
Standar Tes | Standar Perusahaan |
Panggunaan | Intermediate saka Sitagliptin Phosphate Monohydrate (CAS: 654671-77-9) |
Paket: Botol, tas Aluminium foil, 25kg / Drum Karton, utawa miturut kabutuhan pelanggan.
Kondisi panyimpenan:Simpen ing wadhah sing disegel ing papan sing adhem lan garing;Nglindhungi saka cahya lan Kelembapan.
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Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-Butyric Acid (CAS: 486460-00-8) minangka perantara penting kanggo nyiapake sitagliptin.Sitagliptinphosphate minangka inhibitor dipeptidase -IV (DPP-4) pisanan sing disetujoni dening FDA ing taun 2006. Iki digunakake kanggo perawatan diabetes mellitus jinis II.Nduweni efek hypoglycemic sing jelas yen digunakake kanthi mandiri utawa digabungake karo metformin lan pioglitazone, lan aman kanggo njupuk, ditoleransi kanthi apik, kanthi efek samping sing sithik.Ing wulan Agustus 2009, obat kasebut disetujoni dening Uni Eropa minangka obat lini pertama kanggo perawatan diabetes tipe 2.Sawise 2011, siji-sijine negara wis nyetujoni kombinasi sitagliptin fosfat lan inhibitor alpha glycosidase utawa insulin.Sitagliptin fosfat minangka inhibitor dipeptidyl peptidase-IV pisanan sing disetujoni FDA sing digunakake ing perawatan diabetes jinis 2 nganti saiki, kanthi jeneng dagang Januvia.
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Sitagliptin CAS 486460-32-6 Kemurnian >99,0% (HPLC...
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Sitagliptin Phosphate Monohydrate CAS 654671-77...
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2,4,5-Asam Trifluorofenilasetat CAS 209995-38-...
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Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-Buty...
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Sitagliptin Triazole Hydrochloride CAS 762240-9...
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Sitagliptin Phosphate Monohydrate Intermediate...