Daclatasvir Dihydrochloride Intermediate CAS 1007882-23-6 Kemurnian >98,0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. minangka produsen terkemuka Daclatasvir Dihydrochloride Intermediate (CAS: 1007882-23-6) kanthi kualitas dhuwur.Ruifu Chemical bisa nyedhiyakake pangiriman ing saindenging jagad, rega kompetitif, jumlah cilik lan akeh sing kasedhiya.Tuku Daclatasvir Dihydrochloride Intermediates,Please contact: alvin@ruifuchem.com
| Jeneng Kimia | Di-tert-Butyl (2S,2'S)-2,2'-(4,4'-Biphenyldiylbis(1H-imidazol-5,2-diyl))di(1-Pyrrolidinecarboxylate) |
| sinonim | Daclatasvir Intermediate Ⅱ;Dacaltasvir Intermediate 02;Daclatasvir T-Butyl Ester;Bis(2-Methyl-2-Propanyl) (2S,2'S)-2,2'-[4,4'-Biphenyldiylbis(1H-Imidazole-4,2-diyl)]di(1-Pyrrolidinecarboxylate);Di-tert-butil 2,2′-([1,1′-Biphenyl]-4,4′-diylbis(1H-Imidazole-5,2-diyl))(2S,2'S)-bis(Pyridineidine-1- karboksilat);(2S,2'S)-2,2'-([1,1'-Biphenyl]-4,4'-diyldi-1H-Imidazole-5,2-diyl)bis-1-Pyrrolidinecarboxylic Acid 1,1'-Bis (1,1-Dimethylethyl) Ester;Daclatasvir Impurity 4 |
| Status Simpenan | Ing Saham, Produksi Komersial |
| Nomer CAS | 1007882-23-6 |
| Formula Molekul | C40H51ClN8O6 |
| Bobot Molekul | 775,35 g / mol |
| Titik didih | 890.2±65.0 ℃ ing 760 mmHg |
| Kapadhetan | 1,220±0,06 g/cm3 |
| COA & MSDS | kasedhiya |
| asale | Shanghai, China |
| Babagan | Intermediate Daclatasvir Dihydrochloride (CAS: 1009119-65-6) |
| Merk | Kimia Ruifu |
| barang | Spesifikasi | Asil |
| Penampilan | Cahya Kuning nganti Bubuk Kuning | Bubuk Kuning Muda |
| Mundhut ing Pangatusan | <1.00% | 0,65% |
| Pengotor Tunggal Maksimum | <1.00% | 0,45% |
| Total Impurities | <2.00% | 1,24% |
| Kemurnian / Metode Analisis | > 98,0% (HPLC) | 98,76% |
| Spektrum Infrared | Konsisten karo Struktur | tundhuk |
| Spektrum 1H NMR | Konsisten karo Struktur | tundhuk |
| Kesimpulan | Produk wis diuji lan tundhuk karo spesifikasi sing diwenehake | |
| Aplikasi | Intermediate Daclatasvir Dihydrochloride (CAS: 1009119-65-6) | |
Paket:Botol Fluorinated, tas Aluminium foil, 25kg / Drum Karton, utawa miturut kabutuhan pelanggan.
Kondisi panyimpenan:Tansah wadhah ditutup kanthi rapet lan simpen ing gudang sing adhem, garing lan duwe ventilasi sing adoh saka bahan sing ora cocog.Nglindhungi saka cahya lan Kelembapan.
Pengiriman:Ngirim menyang donya liwat udhara, dening FedEx / DHL Express.Nyedhiyakake pangiriman sing cepet lan dipercaya.
Carane Tuku?Mangga kontakDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Pengalaman 15 Taun?Kita duwe luwih saka 15 taun pengalaman ing Pabrik lan ekspor saka sawetara saka sudhut intermediet pharmaceutical kualitas dhuwur utawa bahan kimia nggoleki.
Pasar Utama?Adol menyang pasar domestik, Amerika Utara, Eropa, India, Korea, Jepang, Australia, lsp.
Kaluwihan?Kualitas unggul, rega terjangkau, layanan profesional lan dhukungan teknis, pangiriman cepet.
KualitasJaminan?Sistem kontrol kualitas sing ketat.Peralatan profesional kanggo analisis kalebu NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Sampel?Umume produk nyedhiyakake conto gratis kanggo evaluasi kualitas, biaya pengiriman kudu dibayar dening pelanggan.
Audit Pabrik?Audit pabrik welcome.Mangga nggawe janjian ing advance.
MOQ?Ora MOQ.pesenan cilik ditrima.
Wektu Pangiriman? Yen ing saham, telung dina pangiriman dijamin.
Transportasi?Miturut Express (FedEx, DHL), dening Air, dening Sea.
Dokumen?Sawise layanan sales: COA, MOA, ROS, MSDS, etc.
Sintesis khusus?Bisa nyedhiyakake layanan sintesis khusus sing cocog karo kabutuhan riset sampeyan.
Syarat-syarat pembayaran?Invoice Proforma bakal dikirim dhisik sawise konfirmasi pesenan, dilampirake informasi bank kita.Pembayaran kanthi T / T (Transfer Telex), PayPal, Western Union, lsp.
Di-tert-Butyl (2S,2'S)-2,2'-(4,4'-Biphenyldiylbis(1H-imidazole-5,2-diyl))di(1-Pyrrolidinecarboxylate) (CAS: 1007882-23-6) minangka perantara Daclatasvir Dihydrochloride (CAS: 1009119-65-6).
Daclatasvir (Daklinza) wis entuk status "review prioritas", digabungake karo Sorafenib kanggo perawatan pasien diwasa genotipe III kanthi hepatitis C kronis. Daklinza wis dadi obat pisanan sing wis kabukten efektif ing perawatan virus hepatitis C genotipe III. infèksi tanpa co-administrasi karo interferon utawa ribavirin.Interferon lan Ribavirin minangka rong obat sing disetujoni dening FDA kanggo perawatan infeksi virus hepatitis C.Hepatitis C minangka lelara virus sing bisa nyebabake inflamasi ati, nyebabake fungsi ati mudhun utawa gagal ati.Umume pasien sing kena hepatitis C ora duwe gejala nganti karusakan ati katon, sing mbutuhake sawetara taun.Sacara global, genotipe III hepatitis C minangka genotipe paling umum nomer loro saka hepatitis C sawise genotipe 1 hepatitis C lan dianggep minangka salah sawijining penyakit genotip sing paling refrakter.Daklinza minangka inhibitor kompleks replikasi pan-genotip NS5A, kanthi efektifitas nyegah replikasi RNA lan perakitan virus, efek antivirus ganda.Kanggo studi in vitro, Daklinza wis dituduhake duwe efek anti-virus marang genotipe 1~6 virus hepatitis C.Daklinza diiringi bebaya yen kombinasi amiodarone, Daklinza lan Sofosbuvir bisa nyebabake detak jantung sing suda.Daklinza minangka tablet lisan kanthi dosis sing disaranake 60 mg kanggo 1 kali / d, bebarengan karo Sofosbuvir kanthi total 12 minggu.
Perusahaan riset lan pangembangan: Bristol-Myers Squibb.
Sastra Paten: WO 2008021927A2 (9 Agustus 2007).
Wektu marketing: 24 Juli 2015 kadhaptar ing Amerika Serikat, jeneng dagang Daklinza.
Indikasi: Digunakake ing kombinasi karo Sofosbuvir kanggo perawatan genotipe 3 hepatitis C kronis (HCV) infèksi.
Mekanisme tumindak: HCV nonstructural protein 5A (NS5A) inhibitor.Reaksi salabetipun: sirah lan lemes.
Formulasi lan spesifikasi: Tablet, 30 lan 60mg.
