6,7-Bis(2-Methoxyethoxy)-4(3H)-Quinazolinone CAS 179688-29-0 Erlotinib Hydrochloride Intermediate Purity >99,0% (HPLC)
Produsen utama lan pemasok Erlotinib Hydrochloride Intermediates
Erlotinib Hydrochloride CAS 183319-69-9
3-Ethynylaniline CAS 54060-30-9
6,7-Bis(2-Methoxyethoxy)-3H-Quinazolin-4-siji CAS 179688-29-0
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| Jeneng Kimia | 6,7-Bis(2-Methoxyethoxy)-3H-Quinazolin-4-siji |
| sinonim | 6,7-Bis(2-Methoxyethoxy)-4(3H)-Quinazolinone;6,7-Bis(2-Methoxyethoxy)-3,4-Dihydroquinazolin-4-siji;6,7-Bis(2-Methoxyethoxy)-4-Hydroxyquinazoline;6,7-Bis(2-Methoxyethoxy)-4-Quinazolinol;CP-380736 |
| najis | Erlotinib Impurity A;Erlotinib Lactam Impurity |
| Nomer CAS | 179688-29-0 |
| Nomer CAT | RF2685 |
| Status Simpenan | Ing Simpenan, Skala Produksi Nganti Ton |
| Formula Molekul | C14H18N2O5 |
| Bobot Molekul | 294.31 |
| Titik Lebur | 190,0 kanggo 194,0 ℃ |
| Kapadhetan | 1,26±0,1 g/cm3 |
| Sensitif | Sensitif Udara |
| Merk | Kimia Ruifu |
| Item | Spesifikasi |
| Penampilan | Bubuk Putih utawa Off-White |
| Kemurnian / Metode Analisis | > 99,0% (HPLC) |
| Titik Lebur | 190,0 kanggo 194,0 ℃ |
| Mundhut ing Pangatusan | <0,50% |
| Sisa ing Ignition | <0,20% |
| Related Impurities dening HPLC | |
| Najis individu | <0,50% |
| Total Impurities | <1.00% |
| Logam abot | <10 ppm |
| Spektrum Infrared | Conforms kanggo Struktur |
| Test Standar | Standar Perusahaan |
| Panggunaan | Intermediate Erlotinib Hydrochloride (CAS: 183319-69-9) |
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6,7-Bis(2-Methoxyethoxy)-3H-Quinazolin-4-one (CAS: 179688-29-0) minangka perantara Erlotinib Hydrochloride (CAS: 183319-69-9).Erlotinib Hydrochlorate minangka inhibitor tirosin kinase molekul cilik sing tumindak kanthi reversibel ing reseptor faktor pertumbuhan epidermis, hidroklorida saka erlotinib, obat sing ditargetake molekuler.US Food and Drug Administration (FDA) wis nyetujoni erlotinib (Tarceva) digabungake karo gemcitabine minangka perawatan lini pertama kanggo kanker pankreas sing maju lan metastatik lokal.Utamane digunakake minangka perawatan baris kapindho utawa katelu kanggo kanker paru-paru sel non-cilik (NSCLC) maju utawa metstatic lokal lan minangka perawatan kanggo kanker pankreas.Iki digunakake minangka inhibitor tirosin kanggo perawatan NSCLC.Senyawa molekul cilik Erlotinib Hydrochlorate minangka inhibitor reseptor tirosin kinase sing nyegah proliferasi sel tumor kanthi nyegah fosforilasi, ngiket menyang domain katalitik intraselular tyrosine kinase ing kompetisi karo ATP, saéngga ngalangi transduksi sinyal hilir lan nyegah aktivitas sel tumor gumantung ligan. HER-1/EGFR.
