3-Chloro-4-(3-Fluorobenzyloxy)aniline CAS 202197-26-0 Lapatinib Intermediate Purity >98,0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. minangka produsen terkemuka 3-Chloro-4-(3-Fluorobenzyloxy)aniline (CAS: 202197-26-0) kanthi kualitas dhuwur.Ruifu Chemical bisa nyedhiyakake pangiriman ing saindenging jagad, rega sing kompetitif, layanan sing apik, jumlah cilik lan akeh sing kasedhiya.Tuku Lapatinib Intermediates,Please contact: alvin@ruifuchem.com
Jeneng Kimia | 3-Chloro-4-(3-Fluorobenzyloxy)anilin |
sinonim | 3-Kloro-4-[(3-Fluorofenil)metoksi]anilin;4-(3-Fluorobenzyloxy)-3-Chlorobenzenamine;Lapatinib Intermediate B |
Status Simpenan | Ing Saham, Produksi Komersial |
Nomer CAS | 202197-26-0 |
Formula Molekul | C13H11ClFNO |
Bobot Molekul | 251,69 g / mol |
Titik Lebur | 78,0 kanggo 82,0 ℃ |
Kapadhetan | 1,306±0,06 g/cm3 |
COA & MSDS | kasedhiya |
Sampel | kasedhiya |
asale | Shanghai, China |
Merk | Kimia Ruifu |
barang | Standar Inspeksi | Asil |
Penampilan | Coklat nganti bubuk ireng | tundhuk |
Titik Lebur | 78,0 kanggo 82,0 ℃ | 80,7 ℃ |
Mundhut ing Pangatusan | <1.00% | tundhuk |
Sisa ing Ignition | <0,50% | tundhuk |
Related Impurities dening HPLC | <2.00% | 0,64% |
Kemurnian / Metode Analisis | > 98,0% (HPLC) | 99,36% |
Spektrum 1H NMR | Konsisten karo Struktur | tundhuk |
Kesimpulan | Produk wis diuji lan tundhuk karo spesifikasi sing diwenehake | |
Aplikasi | Intermediate saka Lapatinib / Lapatinib Ditosylate Monohydrate |
Paket:Botol Fluorinated, tas Aluminium foil, 25kg / Drum Karton, utawa miturut kabutuhan pelanggan.
Kondisi panyimpenan:Tansah wadhah ditutup kanthi rapet lan simpen ing gudang sing adhem, garing lan duwe ventilasi sing adoh saka bahan sing ora cocog.Nglindhungi saka cahya lan Kelembapan.
Pengiriman:Ngirim menyang donya liwat udhara, dening FedEx / DHL Express.Nyedhiyakake pangiriman sing cepet lan dipercaya.
Carane Tuku?Mangga kontakDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Pengalaman 15 Taun?Kita duwe luwih saka 15 taun pengalaman ing Pabrik lan ekspor saka sawetara saka sudhut intermediet pharmaceutical kualitas dhuwur utawa bahan kimia nggoleki.
Pasar Utama?Adol menyang pasar domestik, Amerika Utara, Eropa, India, Korea, Jepang, Australia, lsp.
Kaluwihan?Kualitas unggul, rega terjangkau, layanan profesional lan dhukungan teknis, pangiriman cepet.
KualitasJaminan?Sistem kontrol kualitas sing ketat.Peralatan profesional kanggo analisis kalebu NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Sampel?Umume produk nyedhiyakake conto gratis kanggo evaluasi kualitas, biaya pengiriman kudu dibayar dening pelanggan.
Audit Pabrik?Audit pabrik welcome.Mangga nggawe janjian ing advance.
MOQ?Ora MOQ.pesenan cilik ditrima.
Wektu Pangiriman? Yen ing saham, telung dina pangiriman dijamin.
Transportasi?Miturut Express (FedEx, DHL), dening Air, dening Sea.
Dokumen?Sawise layanan sales: COA, MOA, ROS, MSDS, etc.
Sintesis khusus?Bisa nyedhiyakake layanan sintesis khusus sing cocog karo kabutuhan riset sampeyan.
Syarat-syarat pembayaran?Invoice Proforma bakal dikirim dhisik sawise konfirmasi pesenan, dilampirake informasi bank kita.Pembayaran kanthi T / T (Transfer Telex), PayPal, Western Union, lsp.
UN ID 3077
Kode HS 2921420090
Bahaya Kelas 9
Kelompok Pengemasan III
3-Chloro-4-(3-Fluorobenzyloxy)aniline (CAS: 202197-26-0) minangka perantara ing sintesis Lapatinib / Lapatinib Ditosylate Monohydrate.
Lapatinib minangka obat sing nargetake kanker payudara sing dikembangake dening British GlaxoSmithKline Co. Reseptor ErbB manungsa kalebu kulawarga reseptor tyrosine kinase (TK) tipe I, kalebu ErbB1 (EGFR), ErbB2 (HER2), ErbB3 (HER3), lan ErbB4 (HER4) .Reseptor ErbB-1 (EGFR) lan ErbB-2 (HER-2) asring overexpressed utawa diganti ing pasien kanker.Reseptor faktor pertumbuhan epidermis manungsa 2 (ErbB-2, HER-2) dikenal minangka onkogen manungsa sing ana hubungane karo kanker payudara.Ekspresi dhuwur ing kanker payudara asring prédhiksi metastasis kelenjar getah bening lan diferensiasi tumor sing kurang, kanthi prognosis sing kurang.HER-2 minangka salah sawijining molekul target kanggo terapi khusus kanker payudara.Lapatinib bisa tumindak bebarengan ing Her-1 Her-2.Efek biologis saka cara iki nyegah proliferasi lan pertumbuhan sel tumor luwih gedhe tinimbang mung tumindak ing siji target.Kombinasi Lapatinib karo Capecitabine digunakake kanggo nambani pasien kanker payudara lanjut utawa metastatik kanthi overexpression reseptor epidermis manungsa2, sing wis diobati karo anthracyclines, paclitaxel, lan trastuzumab.Uji klinis wis nuduhake yen Lapatinib uga efektif nambani pasien kanker tipe HER2 kanthi resistensi Herceptin.
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