Lapatinib Intermediate CAS 231278-84-5 Kemurnian >98,0% (HPLC)
Jeneng Kimia | 5-[4-[3-Chloro-4-(3-Fluorobenzyloxy)anilino]-6-Quinazolinyl]furan-2-Carboxaldehyde |
sinonim | Lapatinib Intermediate 3;5-[4-[[3-Chloro-4-[(3-Fluorofenil)metoksi]fenil]amino]-6-Quinazolinyl]-2-Furancarboxaldehyde;5-[4-((3-Chloro-4-((3-Fluorobenzyl)oxy)fenil)amino)quinazolin-6-yl]-2-Furaldehyde |
Nomer CAS | 231278-84-5 |
Status Simpenan | Ing Simpenan, Skala Produksi Nganti Ton |
Formula Molekul | C26H17ClFN3O3 |
Bobot Molekul | 473.90 |
Titik Lebur | 225,0 kanggo 235,0 ℃ |
Kapadhetan | 1,407±0,06 g/cm3 |
Indeks bias | 1.694 |
COA & MSDS | kasedhiya |
asale | Shanghai, China |
Merk | Kimia Ruifu |
Item | Spesifikasi |
Penampilan | Kuning pucet nganti kuning bubuk padat |
Kemurnian / Metode Analisis | > 98,0% (HPLC) |
Titik Lebur | 225.0~235.0 ℃ |
Mundhut ing Pangatusan | <1.00% |
Sisa ing Ignition | <0,50% |
Total Impurities | <2.00% |
Logam Berat (Pb) | <20 ppm |
Standar Tes | Standar Perusahaan |
Panggunaan | Intermediate of API (CAS 388082-77-7) |
Paket: Botol, tas Aluminium foil, 25kg / Drum Karton, utawa miturut kabutuhan pelanggan
Kondisi panyimpenan:Simpen ing wadhah sing disegel ing papan sing adhem lan garing;Nglindhungi saka cahya lan Kelembapan
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5-[4-[3-Chloro-4-(3-Fluorobenzyloxy)anilino]-6-Quinazolinyl]furan-2-Carboxaldehyde (CAS: 231278-84-5) minangka perantara API (CAS 388082-77-7 ).(CAS 388082-77-7) minangka obat nargetake kanker payudara sing dikembangake dening British GlaxoSmithKline Co. Iki minangka inhibitor tyrosine kinase sing bisa nyegah aktivitas kinase tirosin saka reseptor faktor pertumbuhan epidermis manungsa 1 lan 2 (ErbB1, ErbB2).Bisa unik tumindak ing macem-macem cara, mesthekake yen sel kanker payudara ora bisa nampa sinyal wutah.Nyandhet situs ATP EGFR (ErbB-1) lan HER2 (ErbB-2) intraselular, nyegah fosforilasi lan aktivasi sel tumor, ngalangi sinyal regulasi mudhun liwat homogenitas lan heterogenitas EGFR (ErbB-1) lan HER2 (ErbB-1) dimerisasi.
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