1-Boc-4-(4-Bromopyrazol-1-yl)piperidine CAS 877399-50-3 Kemurnian ≥98,0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. minangka produsen utama 1-Boc-4-(4-Bromopyrazol-1-yl) piperidine (CAS: 877399-50-3) kanthi kualitas dhuwur, perantara Crizotinib (CAS: 877399- 52-5).Ruifu Chemical bisa nyedhiyakake pangiriman ing saindenging jagad, rega sing kompetitif, layanan sing apik, jumlah cilik lan akeh sing kasedhiya.Tuku Crizotinib Intermediates,Please contact: alvin@ruifuchem.com
| Jeneng Kimia | 1-Boc-4-(4-Bromopyrazol-1-yl)piperidin |
| sinonim | Crizotinib-D;tert-Butil 4-(4-Bromopyrazol-1-yl)piperidine-1-Carboxylate;4-(4-Bromopyrazol-1-yl)piperidine-1-Asam Karboksilat tert-Butil Ester;1-tert-Butoxycarbonyl-4-(4-Bromopyrazol-1-yl)piperidine;1-(4-Boc-Piperidino)-4-Bromopyrazole;1-Boc-4-(4-Bromo-1-Pyrazolyl)piperidine;4-Bromo-1-(N-Boc-Piperidin-4-yl)-1H-Pyrazole;tert-butil 4-(4-Bromo-1H-Pyrazol-1-yl)piperidine-1-Karboksilat;1-(4-Boc-1-Piperidinyl)-4-Bromopyrazole;Pengotor Crizotinib 4 |
| Status Simpenan | Ing Saham, Produksi Komersial |
| Nomer CAS | 877399-50-3 |
| Formula Molekul | C13H20BrN3O2 |
| Bobot Molekul | 330,23 g / mol |
| Titik Lebur | 77,0 kanggo 81,0 ℃ |
| Kapadhetan | 1.43 |
| Kelarutan | Larut ing Metanol |
| COA & MSDS | kasedhiya |
| asale | Shanghai, China |
| Babagan | Penengah saka Crizotinib (CAS: 877399-52-5) |
| Merk | Kimia Ruifu |
| barang | Standar Inspeksi | Asil |
| Penampilan | Putih Solid | Putih Solid |
| Titik Lebur | 77,0 kanggo 81,0 ℃ | tundhuk |
| Banyu dening Karl Fischer | <0,50% | 0,11% |
| Kemurnian / Metode Analisis | ≥98,0% (HPLC) | 99,3% |
| Spektrum 1H NMR | Conforms kanggo Struktur | tundhuk |
| Massa | Conforms kanggo Struktur | tundhuk |
| Kesimpulan | Produk wis diuji & tundhuk karo spesifikasi sing diwenehake | |
Paket:Botol, tas Aluminium foil, 25kg / Drum Karton, utawa miturut kabutuhan pelanggan.
Kondisi panyimpenan:Tansah wadhah ditutup kanthi rapet lan simpen ing gudang sing adhem, garing (2 ~ 8 ℃) lan kanthi ventilasi sing adoh saka bahan sing ora cocog.Nglindhungi saka cahya lan Kelembapan.
Pengiriman:Ngirim menyang donya liwat udhara, dening FedEx / DHL Express.Nyedhiyakake pangiriman sing cepet lan dipercaya.
Carane Tuku?Mangga kontakDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Pengalaman 15 Taun?Kita duwe luwih saka 15 taun pengalaman ing Pabrik lan ekspor saka sawetara saka sudhut intermediet pharmaceutical kualitas dhuwur utawa bahan kimia nggoleki.
Pasar Utama?Adol menyang pasar domestik, Amerika Utara, Eropa, India, Korea, Jepang, Australia, lsp.
Kaluwihan?Kualitas unggul, rega terjangkau, layanan profesional lan dhukungan teknis, pangiriman cepet.
KualitasJaminan?Sistem kontrol kualitas sing ketat.Peralatan profesional kanggo analisis kalebu NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Sampel?Umume produk nyedhiyakake conto gratis kanggo evaluasi kualitas, biaya pengiriman kudu dibayar dening pelanggan.
Audit Pabrik?Audit pabrik welcome.Mangga nggawe janjian ing advance.
MOQ?Ora MOQ.pesenan cilik ditrima.
Wektu Pangiriman? Yen ing saham, telung dina pangiriman dijamin.
Transportasi?Miturut Express (FedEx, DHL), dening Air, dening Sea.
Dokumen?Sawise layanan sales: COA, MOA, ROS, MSDS, etc.
Sintesis khusus?Bisa nyedhiyakake layanan sintesis khusus sing cocog karo kabutuhan riset sampeyan.
Syarat-syarat pembayaran?Invoice Proforma bakal dikirim dhisik sawise konfirmasi pesenan, dilampirake informasi bank kita.Pembayaran kanthi T / T (Transfer Telex), PayPal, Western Union, lsp.
Simbol Bahaya Xn - Mbebayani
Kode Resiko 22 - Mbebayani yen ditelan
1-Boc-4-(4-Bromopyrazol-1-yl)piperidine (CAS: 877399-50-3) digunakake minangka perantara Crizotinib (CAS: 877399-52-5).Crizotinib (jeneng dagang Xalkori,) minangka obat anti-kanker sing tumindak minangka ALK (anaplastic lymphoma kinase) lan ROS1 (c-ros oncogene 1) inhibitor, disetujoni kanggo perawatan sawetara karsinoma paru-paru sel non-cilik (NSCLC) ing AS. lan sawetara negara liyane, lan ngalami uji klinis nguji safety lan khasiat limfoma sel gedhe inanaplastik, neuroblastoma, lan tumor padhet maju liyane ing wong diwasa lan bocah.
Ing wulan Agustus 2011, FDA Amerika Serikat nyetujoni Crizotinib (PF-02341066) kanggo perawatan kanker paru-paru non-sel cilik (NSCLC) anaplastic lymphoma kinase (ALK).Crizotinib minangka inhibitor kompetitif ATP ganda saka tyrosine kinase c-MET (Mesenchymal-Epithelial Transition Factor) kinase (cellular IC50 = 8 nM) lan ALK (cellular IC50 = 20 nM), loro-lorone minangka target penting kanggo kemoterapi kanker.Nalika Crizotinib dites kanggo selektivitas lawan kinase liyane, ditemokake duwe enzim IC50 ing kelipatan 100 kali c-MET kanggo 13 saka 120 kinase sing diuji.Ing tes seluler, Crizotinib ditemokake kanggo nyandhet RON (recepteur d'origine nantais) kinase kanthi jendela selektivitas 10 kali lipat liwat c-MET.
