Darunavir Ethanolate CAS 635728-49-3 Kemurnian ≥99.0% Pabrik API Anti-HIV HIV Protease Inhibitor
Produsen Pasokan Darunavir Produk terkait:
Darunavir CAS 206361-99-1
Darunavir Ethanolate CAS 635728-49-3
(2S,3S)-1,2-Epoxy-3-(Boc-Amino)-4-Phenylbutane CAS 98737-29-2
(2R,3S)-1,2-Epoxy-3-(Boc-Amino)-4-Phenylbutane CAS 98760-08-8
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| Jeneng Kimia | Darunavir Ethanolate |
| sinonim | DRV;Prezista;TMC114 Etanolat;UNII-33O78XF0BW;N-[(1S,2R)-3-[[(4-Aminophenyl)sulfonyl](2-metilpropil)amino]-2-hidroksi-1-(fenilmetil)propil]asam karbamat (3R,3aS,6aR)-heksahidrofuro [2,3-b]furan-3-yl ester compd.karo etanol |
| Nomer CAS | 635728-49-3 |
| Nomer CAT | RF-API69 |
| Status Simpenan | Ing Stok, Skala Produksi Nganti Atusan Kilogram |
| Formula Molekul | C29H43N3O8S |
| Bobot Molekul | 593.73 |
| Merk | Kimia Ruifu |
| Item | Spesifikasi |
| Penampilan | Bubuk Kristal Putih utawa Off-White |
| Identifikasi IR | Cocog karo Spektrum Standar |
| Rotasi spesifik | -0,5°~ +0,5° |
| Zat sing gegandhengan | (dening HPLC) |
| Max Single Impurity | ≤0,20% |
| Total Impurities | ≤0,50% |
| Banyu (KF) | ≤1,0% |
| Sisa ing Ignition | ≤0,10% |
| Logam abot | ≤10ppm |
| Kandungan Etanol | ≤7,5% (GC) |
| Sisa Solvents | Metanol ≤0,30% |
| Kemurnian | ≥99,0% (HPLC) |
| Test Standar | Standar Perusahaan |
| Panggunaan | Darunavir Ethanolate HIV-1 Protease Inhibitor Anti-HIV Antiviral |
Paket: Botol, tas Aluminium foil, Drum Karton, 25kg / Drum, utawa miturut kabutuhan pelanggan.
Kondisi panyimpenan:Simpen ing wadhah sing disegel ing papan sing adhem lan garing;Nglindhungi saka cahya, kelembapan lan infestasi hama.
Darunavir Ethanolate (Prezista) minangka inhibitor protease HIV.Turunan Darunavir, inhibitor HIV-1-protease generasi kapindho;struktural padha karo amprenavir.Antivirus.Iki minangka produk riset sing gegandhengan karo COVID19.Sayange, DRV nduweni kelarutan sing kurang ing banyu lan bioavailabilitas sing kurang, mula mbutuhake administrasi ing dosis sing relatif dhuwur supaya bisa nuduhake khasiat terapeutik.Darunavir minangka inhibitor kuat spektrum luas sing aktif nglawan isolat klinis HIV-1 kanthi sitotoksisitas minimal.Darunavir mbentuk ikatan hidrogen karo atom rantai utama sing dikonservasi saka Asp29 lan Asp30 saka protease.Interaksi kasebut diusulake dadi kritis kanggo potensi senyawa iki marang isolat HIV sing tahan kanggo macem-macem inhibitor protease.Ing studi in vitro ing sel MT-2, potensi darunavir luwih gedhe tinimbang saquinavir, amprenavir, nelfinavir, indinavir, lopinavir lan ritonavir.Darunavir utamane dimetabolisme dening enzim hepatic cytochrome P450 (CYP), utamane CYP3A.Dosis ritonavir sing 'ngundhakake' tumindak minangka inhibitor CYP3A, saéngga nambah bioavailabilitas darunavir.Darunavir dirancang kanggo mbentuk interaksi sing kuat karo enzim protease saka akeh galur HIV, kalebu galur saka pasien sing ngalami perawatan kanthi macem-macem mutati resistensi.
