Asam Dietilphosphonoacetic CAS 3095-95-2 Kemurnian > 99,5% (HPLC) Afatinib Dimaleate Intermediate Factory

Katrangan singkat:

Jeneng Kimia: Diethylphosphonoacetic Acid

CAS: 3095-95-2

Kemurnian:> 99,5% (HPLC)

Penampilan: Cairan tanpa warna

Penengah saka Afatinib Dimaleate (CAS: 850140-73-7)

Kualitas Tinggi, Produksi Komersial

E-Mail: alvin@ruifuchem.com

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katrangan:

Ruifu Chemical Supply Intermediates saka Afatinib
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Afatinib Dimaleate CAS 850140-73-7
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Asam Dietilphosphonoacetic CAS 3095-95-2
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Sifat Kimia:

Jeneng Kimia	Asam Dietilphosphonoacetic
sinonim	2- (Diethoxyphosphoryl)Asam asetat;(Diethoxyphosphinyl)asam asetat;Dietil Carboxymethylphosphonate;NSC 272281
Nomer CAS	3095-95-2
Nomer CAT	RF-PI2024
Status Simpenan	Ing Simpenan, Kapasitas Produksi 30MT / Wulan
Formula Molekul	(C2H5O)2P(O)CH2CO2H
Bobot Molekul	196.14
Titik didih	150 ℃ / 0,05 mmHg (lit.)
Kapadhetan	1,220 g/mL ing 25 ℃ (lit.)
Indeks bias	n20/D 1,445 (lit.)
Merk	Kimia Ruifu

Spesifikasi:

Item	Spesifikasi
Penampilan	Cairan Tanpa Warna
Identifikasi (HPLC)	Wektu retensi puncak utama sing dipikolehi saka sampel yaiku ing 5% saka sampel referensi.
Kemurnian / Metode Analisis	> 99,5% (HPLC)
Spektrum Infrared	Conforms kanggo Struktur
Proton NMR Spectrum	Conforms kanggo Struktur
Kelembapan (KF)	<0,50%
Total Impurities	<0,50%
Test Standar	Standar Perusahaan
Panggunaan	Penengah saka Afatinib Dimaleate (CAS: 850140-73-7)

Paket & Panyimpenan:

Paket: Botol Fluorinated, 25kg / Drum, utawa miturut kabutuhan pelanggan

Kondisi panyimpenan:Simpen ing wadhah sing disegel ing papan sing adhem lan garing;Nglindhungi saka cahya lan Kelembapan

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Diethylphosphonoacetic Acid (CAS: 3095-95-2), Tumindak minangka nukleofil kanggo reaksi tambahan nukleofilik kanggo sintesis epoksida allene Reaktan kanggo: Studi stereoselektifitas reaksi Staudinger;Pembentukan enantioselektif diol liwat reaksi epoksidasi lan hidrasi;reaksi Horner-Wadsworth-Emmons;Chelation remot kontrol rearrangement Ireland-Claisen;Reaksi Ugi-Dieckmann kanggo sintesis turunan asam tetramat;Digunakake kanggo nggawe intermediet fosfonoester kanggo reaksi HEW intramolekul.Asam Dietilphosphonoacetic minangka perantara saka Afatinib Dimaleate (CAS: 850140-73-7).Afatinib Dimaleate disetujoni dening US Food and Drug Administration (FDA) ing 2013 kanggo perawatan kanker paru-paru sel non-cilik (NSCLC).Khusus, disetujoni kanggo pasien sing ngalami tumor NSCLC metastatik sing ngemot penghapusan ekson reseptor faktor pertumbuhan epidermal (EGFR) utawa mutasi exon 21.Afatinib Dimaleate minangka inhibitor kovalen saka ErbB tyrosine kinase (tyk), sing nyuda sinyal ErbB kanthi ikatan sing ora bisa dibatalake saka situs pengikat EGFR tyk.