Etil (S)-4-Chloro-3-hydroxybutyrate CAS 86728-85-0 Atorvastatin Calcium Intermediate
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Jeneng Kimia | Etil (S)-4-Chloro-3-hydroxybutyrate |
sinonim | (S)-4-Chloro-3-hydroxybutyric Acid Ethyl Ester |
Nomer CAS | 86728-85-0 |
Nomer CAT | RF-PI139 |
Status Simpenan | Ing Simpenan, Skala Produksi Nganti Ton |
Formula Molekul | C6H11ClO3 |
Bobot Molekul | 166.6 |
Kapadhetan | 1,19 g/mL ing 25 ℃ (lit.) |
Indeks bias | n20/D 1.453 (lit.) |
Merk | Kimia Ruifu |
Item | Spesifikasi |
Penampilan | Cairan ora ana warna nganti kuning pucat |
Kemurnian / Metode Analisis | ≥98,0% (GC) |
Kelembapan (KF) | ≤0,50% |
Etil-4-Chloro Aceto Acetate | ≤0,50% |
Standar Tes | Standar Perusahaan |
Panggunaan | Pharmaceutical Intermediate;Sintesis Organik |
Etil (S)-4-Chloro-3-hydroxybutyrate (CAS: 86728-85-0)
Metode analisis
Katrangan
Njupuk kira-kira 10 ml sampel ing piring kaca sing resik lan garing lan priksa.
rotasi tartamtu
Transfer kanthi akurat babagan 1.0g sampel menyang labu volumetrik 100ml lan dibubarake10 ml kloroform, banjur diencerke karo kloroform nganti 100 ml lan nyampur.
Ukur rotasi optik sampel uji ing 25ºC lan dawa gelombang 589nmngitung rotasi tartamtu miturut rumus diwenehi.
[α]25D = (v×a)/[w×(1-b)]
[α]25D: rotasi spesifik tessampel;α: rotasi sing diamati ingderajat sudut;w: bobot sampel (g);
v: volume (mL);
b: kandungan banyu (%)
Kemurnian (dening GC)
Kondisi kromatografi: Kromatografi gas dilengkapi nyaladetektor ionisasi
Kolom: SE-54, 30m×0.35mm×0.25µm
Suhu Oven: Suhu awal 120 ℃, Tahan wektu 2 menit
Ramp: 20 ℃ / min
Suhu: 250 ℃, Tahan wektu 2 menit
Suhu injeksi: 250 ℃
Suhu detektor: 250 ℃ (FID)
Volume injeksi: 0,2µl
Solusi sampel: dilute 1ml A4 karo 1ml aseton.
Prosedur: Nyuntikake 0,2µl aseton minangka kosong lan rekam kromatogram.Ingkromatogram sing dipikolehi saka diluent ngirim ora ana gangguan ingwektu retensi puncak utama lan puncak impurity.Saka Inject solusi sampel ingduplikat menyang kromatografi lan rekam kromatogram kasebut.Laporan Kemurnian sakasampel kanthi metode normalisasi area.
Paket: Botol, Barel, 25kg / Barrel, utawa miturut kabutuhan pelanggan.
Kondisi panyimpenan:Simpen ing wadhah sing disegel ing papan sing adhem lan garing;Nglindhungi saka cahya, kelembapan lan infestasi hama.
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Shanghai Ruifu Chemical Co., Ltd. minangka produsen utama lan pemasok Ethyl (S)-4-Chloro-3-hydroxybutyrate (CAS: 86728-85-0) kanthi kualitas dhuwur, minangka perantara biasane ing sintesis Atorvastatin Kalsium (CAS: 134523-03-8).
Atorvastatin Calcium (CAS: 134523-03-8) [jeneng dagang: Lipitor] utamane dituduhake kanggo perawatan penyakit kardiovaskular lan dislipidemia amarga efeke nyuda kolesterol ing getih.Atorvastatin tumindak utamane ing ati.Suda tingkat kolesterol hepatik luwih nambah penyerapan kolesterol hepatik lan nyuda tingkat kolesterol plasma.Lipitor, wiwit taun 1996, wis dadi obat paling laris ing donya nganti saiki.
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