N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pirimidin-2-amine CAS 152460-09-8 Imatinib Mesylate Intermediate High Purity
Pasokan Komersial Imatinib Mesylate lan Intermediet sing Gegandhengan:
Imatinib Mesylate CAS: 220127-57-1
N-(2-Metil-5-nitrofenil)-4-(piridin-3-yl)pirimidin-2-amin CAS: 152460-09-8
N-(5-Amino-2-methylphenyl)-4-(3-piridil)-2-pirimidinea CAS: 152460-10-1
4- [(4-Methylpiperazin-1-yl)metil]asam benzoat dihidroklorida CAS: 106261-49-8
Jeneng Kimia | N-(2-Metil-5-nitrofenil)-4-(piridin-3-yl)pirimidin-2-amin |
sinonim | Imatinib Mesylate Intermediate;2-(2-Metil-5-nitroanilino)-4-(3-piridil)pirimidin |
Nomer CAS | 152460-09-8 |
Nomer CAT | RF-PI228 |
Status Simpenan | Ing Simpenan, Skala Produksi Nganti Ton |
Formula Molekul | C16H13N5O2 |
Bobot Molekul | 307.31 |
Titik Lebur | 188.0~193.0 ℃ |
Merk | Kimia Ruifu |
Item | Spesifikasi |
Penampilan | Bubuk Kuning utawa Meh Kuning |
Kemurnian | ≥98,0% (HPLC) |
Kelembapan (KF) | ≤0,50% |
Total Impurities | ≤2,0% |
Pengotor Tunggal Maksimum | ≤1,0% |
Sisa ing ignition | ≤0,50% |
Logam abot | ≤20ppm |
Standar Tes | Standar Perusahaan |
Panggunaan | Intermediate saka Imatinib Mesylate (CAS: 220127-57-1) |
Paket: Botol, tas Aluminium foil, Drum karton, 25kg / Drum, utawa miturut kabutuhan pelanggan.
Kondisi panyimpenan:Simpen ing wadhah sing disegel ing papan sing adhem lan garing;Nglindhungi saka cahya, kelembapan lan infestasi hama.
Shanghai Ruifu Chemical Co., Ltd. minangka produsen utama lan pemasok N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl) pirimidin-2-amine (CAS: 152460-09-8) kanthi kualitas dhuwur.Iki minangka perantara biasane ing sintesis Imatinib Mesylate (CAS: 220127-57-1).
Imatinib Mesylate minangka molekul cilik sing nyandhet c-Abl protein-tirosin kinase, Highly spesifik kanggo BCR-ABL, enzim sing digandhengake karo leukemia myelogenous kronis (CML) lan wangun tartamtu saka leukemia limfoblastik akut (ALL).Acara translokasi antarane kromosom 9 lan 22 ngasilake kromosom Philadelphia, sing banjur ngasilake protein fusi Bcr-Abl kanthi aktivitas kinase aberan sing ningkatake proliferasi sel kanthi cepet.Imatinib Mesylate ngiket kinase penting iki, nyegah pertumbuhan sing ana hubungane karo CML.Imatinib Mesylate wis luwih ditampilake kanggo nyandhet PDGFR lan tyrosine kinase sing ana gandhengane karo c-Kit.Formulasi sing ngemot Imatinib Mesylate wis digunakake ing perawatan macem-macem kanker.