N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea CAS 152460-10-1 Imatinib Mesylate Intermediate High Purity
Pasokan Komersial Imatinib Mesylate lan Intermediet sing Gegandhengan:
Imatinib Mesylate CAS: 220127-57-1
N-(2-Metil-5-nitrofenil)-4-(piridin-3-yl)pirimidin-2-amin CAS: 152460-09-8
N-(5-Amino-2-methylphenyl)-4-(3-piridil)-2-pirimidinea CAS: 152460-10-1
4- [(4-Methylpiperazin-1-yl)metil]asam benzoat dihidroklorida CAS: 106261-49-8
| Jeneng Kimia | N-(5-Amino-2-methylphenyl)-4-(3-piridil)-2-pirimidinea |
| sinonim | Imatinib Mesylate Intermediate;2-(5-Amino-2-methylanilino)-4-(3-piridil)pirimidin |
| Nomer CAS | 152460-10-1 |
| Nomer CAT | RF-PI230 |
| Status Simpenan | Ing Simpenan, Skala Produksi Nganti Ton |
| Formula Molekul | C16H15N5 |
| Bobot Molekul | 277.32 |
| Titik Lebur | 133,0-135,0 ℃ |
| Merk | Kimia Ruifu |
| Item | Spesifikasi |
| Penampilan | Oranye cahya nganti bubuk kuning nganti kristal |
| Kemurnian / Metode Analisis | ≥98,0% |
| Mundhut ing Pangatusan | ≤0,50% |
| Sisa ing ignition | ≤0,50% |
| Total Impurities | ≤2,0% |
| Pengotor Tunggal Maksimum | ≤1,0% |
| Logam abot | ≤20ppm |
| Standar Tes | Standar Perusahaan |
| Panggunaan | Intermediate saka Imatinib Mesylate (CAS: 220127-57-1) |
Paket: Botol, tas Aluminium foil, Drum karton, 25kg / Drum, utawa miturut kabutuhan pelanggan.
Kondisi panyimpenan:Simpen ing wadhah sing disegel ing papan sing adhem lan garing;Nglindhungi saka cahya, kelembapan lan infestasi hama.
Shanghai Ruifu Chemical Co., Ltd. minangka produsen lan pemasok utama N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea (CAS: 152460-10-1) kanthi kualitas dhuwur .
N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea (CAS: 152460-10-1) minangka perantara biasane ing sintesis Imatinib Mesylate (CAS: 220127-57-1) ) APIK.
Imatinib mesylate minangka molekul cilik sing nyegah c-Abl protein-tirosin kinase, kinase sing penting banget kanggo proliferasi leukemia myelogenous kronis (CML).Acara translokasi antarane kromosom 9 lan 22 ngasilake kromosom Philadelphia, sing banjur ngasilake protein fusi Bcr-Abl kanthi aktivitas kinase aberan sing ningkatake proliferasi sel kanthi cepet.Imatinib mesylate ngubungake kinase penting iki, nyegah pertumbuhan sing gegandhengan karo CML.Imatinib mesylate wis luwih ditampilake kanggo nyandhet PDGFR lan tyrosine kinase sing ana gandhengane karo c-Kit.Formulasi sing ngemot Imatinib mesylate wis digunakake ing perawatan macem-macem kanker.
Imatinib mesylate minangka inhibitor tirosin kinase.Spesifik banget kanggo BCR-ABL, enzim sing ana gandhengane karo leukemia myelogenous kronis (CML) lan leukemia limfoblastik akut (ALL) tartamtu.Iku v-Abl tyrosine kinase inhibitor kuat lan selektif (IC50 = 38 nM).Uga nyegah PDGFR lan c-kit.Nuduhake selektivitas kanggo v-Abl liwat panel tirosin lan serine / threonine protein kinase liyane.Selektif nyandhet wutah PDGF-stimulus saka v-abl-transformed sel PB-3 lan v-sis-transformed sel BALB / c 3T3 in vitro.Nuduhake efek antitumor ing tikus sing duwe sel AMuLV utawa BBL / c 3T3 v-sis.Nyandhet replikasi SARS-CoV lan MERS-CoV in vitro (Nilai EC50 yaiku 9.823 lan 17.689 μM, masing-masing).
![4- [(4-Methylpiperazin-1-yl)metil]asam benzoat dihidroklorida CAS 106261-49-8 Imatinib Mesylate Intermediate High Purity](https://www.ruifuchemical.com/uploads/d1fa2a19-300x300.jpg)