Imatinib Mesylate CAS 220127-57-1 Assay 98.0%~102.0% Ph+CML API Pabrik Kualitas Tinggi
Pasokan Komersial Imatinib Mesylate lan Intermediet sing Gegandhengan:
Imatinib Mesylate CAS: 220127-57-1
N-(2-Metil-5-nitrofenil)-4-(piridin-3-yl)pirimidin-2-amin CAS: 152460-09-8
N-(5-Amino-2-methylphenyl)-4-(3-piridil)-2-pirimidinea CAS: 152460-10-1
4- [(4-Methylpiperazin-1-yl)metil]asam benzoat dihidroklorida CAS: 106261-49-8
| Jeneng Kimia | Imatinib Mesylate (bentuk alfa) |
| sinonim | Imatinib Methanesulfonate;STI571 Mesylate;CGP-57148B |
| Nomer CAS | 220127-57-1 |
| Nomer CAT | RF-API19 |
| Status Simpenan | Ing Simpenan, Skala Produksi Nganti Ton |
| Formula Molekul | C30H35N7O4S |
| Bobot Molekul | 589.71 |
| Kondisi Pengiriman | Ing Suhu Sekitar |
| Merk | Kimia Ruifu |
| Item | Spesifikasi |
| Penampilan | Bubuk Kristal Putih nganti Putih |
| Kelarutan | Gampang larut ing banyu |
| Identifikasi HPLC | Spektrum sampel wektu retensi puncak utama cocog karo sing |
| Identifikasi IR | Spektrum panyerepan inframerah saka sampel cocog karo sampel referensi |
| Titik Lebur | 214.0~222.0 ℃ |
| Mundhut ing Pangatusan | ≤0,50% |
| Sisa ing Ignition | ≤0,10% |
| Logam abot | ≤20ppm |
| Zat sing gegandhengan | (1) Pengotor G: NMT 0,3% |
| (2) Kotoran B: NMT 0,3% | |
| (3) Pengotor C: NMT 0,3% | |
| (4) Kotoran D: NMT 0,3% | |
| (5) Kotoran A: NMT 0,3% | |
| (6) Kotor H: NMT 0,3% | |
| (7) Kotoran F: NMT 0,3% | |
| (8) Kotoran E: NMT 0,3% | |
| (9) Pengotor tunggal paling gedhe: NMT0.1% | |
| Sisa Solvents | (1) Etil Asetat: NMT 5000ppm |
| (2) Metanol: NMT3000ppm | |
| (3) Diklorometana: NMT 600ppm | |
| (4) Etanol: NMT 5000ppm | |
| (5) Toluene: NMT 890ppm | |
| (6) Dimetil Sulfoksida: NMT5000ppm | |
| Pengujian HPLC | 98,0%~102,0% (C30H35N7SO4 Diwilang ing Basis Anhidrat) |
| Test Standar | Standar Perusahaan |
| Panggunaan | API;Ph+CML |
Paket: Botol, tas Aluminium foil, Drum karton, 25kg / Drum, utawa miturut kabutuhan pelanggan.
Kondisi panyimpenan:Simpen ing wadhah sing disegel ing papan sing adhem lan garing;Nglindhungi saka cahya, kelembapan lan infestasi hama.
Imatinib Mesylate (CAS 220127-57-1) minangka molekul cilik sing nyegah c-Abl protein-tirosin kinase, kinase sing penting banget kanggo proliferasi leukemia myelogenous kronis (CML).Spesifik banget kanggo BCR-ABL, enzim sing ana gandhengane karo leukemia myelogenous kronis (CML) lan leukemia limfoblastik akut (ALL) tartamtu.Iku v-Abl tyrosine kinase inhibitor kuat lan selektif (IC50 = 38 nM).Acara translokasi antarane kromosom 9 lan 22 ngasilake kromosom Philadelphia, sing banjur ngasilake protein fusi Bcr-Abl kanthi aktivitas kinase aberan sing ningkatake proliferasi sel kanthi cepet.Imatinib mesylate ngubungake kinase penting iki, nyegah pertumbuhan sing gegandhengan karo CML.Imatinib mesylate wis luwih ditampilake kanggo nyandhet PDGFR lan tyrosine kinase sing ana gandhengane karo c-Kit.
![4- [(4-Methylpiperazin-1-yl)metil]asam benzoat dihidroklorida CAS 106261-49-8 Imatinib Mesylate Intermediate High Purity](https://www.ruifuchemical.com/uploads/d1fa2a19-300x300.jpg)