Irinotecan Hydrochloride CAS 100286-90-6 Purity ≥99.0% (HPLC) API USP Standard High Purity
Produsen Pasokan Irinotecan lan Intermediet sing gegandhengan:
Irinotecan Hydrochloride CAS: 100286-90-6
Irinotecan Free Base CAS: 97682-44-5
Irinotecan Hydrochloride Trihydrate CAS: 136572-09-3
7-Ethyl-10-Hydroxycamptothecin CAS: 86639-52-3
1-Chlorocarbonyl-4-Piperidinopiperidine Hydrochloride CAS: 143254-82-4
| Jeneng Kimia | Irinotecan Hydrochloride |
| sinonim | Camptothecin II;CPT-II |
| Nomer CAS | 100286-90-6 |
| Nomer CAT | RF-API50 |
| Status Simpenan | Ing Simpenan, Skala Produksi Nganti Ton |
| Formula Molekul | C33H39ClN4O6 |
| Bobot Molekul | 623.15 |
| Titik Lebur | 250-256 ℃ (des.) |
| Kahanan Panyimpenan | Ing Suhu Sekitar |
| Merk | Kimia Ruifu |
| Item | Spesifikasi |
| Penampilan | Bubuk Putih utawa Off-White |
| Kelarutan | Larut ing banyu lan metanol, rada larut ing kloroform, etanol |
| Identifikasi IR | Spektrum panyerepan inframerah saka sampel tes kudu konsisten karo standar referensi |
| Identifikasi HPLC | Wektu penylametan puncak utama solusi sampel kudu cocog karo standar referensi. |
| Identifikasi | Memenuhi syarat tes kanggo reaksi Klorida Positif |
| Kelembapan (KF) | 7,0% ~ 9,0% w/w |
| Sisa ing Ignition | ≤0,10% |
| Logam abot | ≤20ppm |
| Irinotecan Hydrochloride Enantiomer | ≤0,10% (HPLC) |
| 7-Desethyl Irinotecan | ≤0,15% |
| Senyawa sing gegandhengan karo Irinotecan A | ≤0,15% |
| 11-Etil Irinotecan | ≤0,15% |
| Camptothecin | ≤0,15% |
| Senyawa sing gegandhengan karo Irinotecan B | ≤0,15% |
| 7-Etilcanptothecin | ≤0,15% |
| 7,11-Diethyl-10-Hydroxy Camptothecin | ≤0,15% |
| Sembarang Kotor sing Ora Ditemtokake | ≤0,10% |
| Total Impurities | ≤0,50% |
| Sisa Pelarut (GC) | |
| Metanol | ≤2000ppm |
| Aseton | ≤2000ppm |
| Diklorometana | ≤500ppm |
| Peteoleum Eter: | ≤100ppm |
| Etil Asetat | ≤2000ppm |
| Benzene | ≤2ppm |
| Endotoksin Bakteri | ≤0,29 EU/mg Irinotecan |
| Watesan Mikroba | Jumlah Mikroba Aerobik: <1000 cfu/g |
| Molds lan Ragi | <100 cfu/g |
| Kemurnian / Metode Analisis | ≥99,0% (HPLC, kanthi basis anhidrat) |
| Test Standar | United States Pharmacopeia (USP) Standard |
| Panggunaan | Active Pharmaceutical Ingredient (API) |
Paket: Botol, tas Aluminium foil, Drum karton, 25kg / Drum, utawa miturut kabutuhan pelanggan.
Kondisi panyimpenan:Simpen ing wadhah sing disegel ing papan sing adhem lan garing;Nglindhungi saka cahya, kelembapan lan infestasi hama.
lrinotecan hydrochloride (CAS 100286-90-6), turunan semi-sintetik, larut banyu saka agen antikanker camptothecin sing kuat, diluncurake ing Jepang kanggo perawatan kanker paru-paru, ovarium, lan serviks.lrinotecan bisa nindakake aktivitas antitumor liwat inhibisi topoisomerase I, sawijining enzim seluler sing melu njaga struktur topografi DNA sajrone proses translasi, transkripsi, lan mitosis.lrinotecan ngalami de-esterifikasi in vivo kanggo ngasilake metabolit aktif, SN-38, sing 1000 kali luwih kuat tinimbang wong tuwa.Terapi kombinasi irinotecan karo agen antikanker liyane sing akeh digunakake, cisplatin, wis dilapurake luwih unggul tinimbang agen kasebut.lrinotecan ana ing uji klinis kanggo gastrointestinal, payudara, kulit, kolorektal, kanker pankreas, mesothelioma lan limfoma non-Hodgkin.
