Molnupiravir (EIDD-2801) CAS 2349386-89-4 COVID-19 API Kualitas Tinggi
Molnupiravir Pasokan Komersial lan Intermediet sing Gegandhengan kanthi Kualitas Tinggi
Uridine CAS 58-96-8
Cytidine CAS 65-46-3
Molnupiravir N-1 CAS 2346620-55-9
Molnupiravir (EIDD-2801) CAS 2349386-89-4
| Jeneng Kimia | Molnupiravir (EIDD-2801) |
| sinonim | MK-4482;β-D-N4-Hydroxycytidine-5′-isopropyl ester;((2R,3S,4R,5R)-3,4-dihydroxy-5-((E)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2 -yl) metil isobutirat |
| Nomer CAS | 2349386-89-4 |
| Nomer CAT | RF-API97 |
| Status Simpenan | Ing Stok, Skala Produksi Nganti Atusan Kilogram |
| Formula Molekul | C13H19N3O7 |
| Bobot Molekul | 329.31 |
| Kelarutan | Larut ing DMSO |
| Merk | Kimia Ruifu |
| Item | Spesifikasi |
| Penampilan | Bubuk Putih nganti Putih |
| Identifikasi IR | Spektrum Sampel cocog karo standar referensi |
| Identifikasi HPLC | Wektu retensi puncak utama solusi sampel cocog karo solusi standar |
| Zat sing gegandhengan | |
| Najis A | ≤0,15% |
| Najis B | ≤0,15% |
| Sembarang Kotor sing Ora Ditemtokake | ≤0,15% |
| Total Impurities Unspecified | ≤0,30% |
| Total Impurities | ≤0,50% |
| Sisa Solvents | |
| N-Heptana | ≤5000ppm |
| Etanol | ≤5000ppm |
| Isopropil Asetat Kab | ≤5000ppm |
| asetonitril | ≤410ppm |
| Metilena Diklorida | ≤600ppm |
| Aseton | ≤5000ppm |
| Isopropanol | ≤5000ppm |
| Kandungan Air (KF) | ≤0,50% |
| Sisa ing Ignition | ≤0,10% |
| Rotasi Optik | -7,5° nganti -9,5° (C=0,5, Metanol) |
| Logam abot | ≤10ppm |
| Kemurnian / Metode Analisis | ≥99,5% (230nm) |
| Metode Assay/Analisis | 98,0% ~ 102,0% (HPLC ing basis garing) |
| Urip beting | 24 wulan |
| Test Standar | Standar Perusahaan |
| Panggunaan | API, Molnupiravir (EIDD-2801) COVID-19 Inhibitor |
Paket: Botol, tas Aluminium foil, Drum karton, 25kg / Drum, utawa miturut kabutuhan pelanggan.
Kondisi panyimpenan:Simpen ing wadhah sing disegel ing papan sing adhem lan garing;Nglindhungi saka cahya, kelembapan lan infestasi hama.
Molnupiravir (EIDD-2801, MK-4482) minangka prodrug bioavailable oral saka analog ribonucleoside β-d-N4-hydroxycytidine (NHC; EIDD-1931) kanthi aktivitas antivirus spektrum luas marang SARS-CoV-2, MERS-CoV, SARS-CoV, lan agen penyebab COVID-19.Molnupiravir didol kanthi jeneng merek Lagevrio lan umume minangka emorivir.Molnupiravir wis ditampilake kanggo nambah fungsi paru-paru, nyuda bobot awak lan nyuda jumlah virus ing paru-paru.Saliyane aktivitas nglawan coronavirus, Molnupiravir, ing studi laboratorium, wis nuduhake aktivitas nglawan influenza musiman lan manuk, virus respiratory syncytial, virus chikungunya, virus Ebola, virus encephalitis equine Venezuela, lan virus ensefalitis equine Timur.Molnupiravir wiwitane dikembangake kanggo nambani influenza ing Universitas Emory dening perusahaan inovasi obat universitas kasebut, Drug Innovation Ventures at Emory (DRIVE), nanging kabare ditinggal amarga masalah mutagenisitas.Banjur dituku dening Ridgeback Biotherapeutics perusahaan sing berbasis ing Miami, sing banjur kerja bareng karo Merck & Co kanggo ngembangake obat kasebut.Molnupiravir disetujoni kanggo panggunaan medis ing Inggris ing November 2021.
