N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1 Kemurnian > 99,0% (HPLC) Afatinib Dimaleate Intermediate Factory

Katrangan singkat:

Jeneng Kimia: N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine

CAS: 162012-67-1

Kemurnian: >99,0% (HPLC)

Penampilan: Kuning cahya nganti bubuk kuning

Penengah saka Afatinib Dimaleate (CAS: 850140-73-7)

E-Mail: alvin@ruifuchem.com

Kirimi email kanggo kita

Detail Produk

Produk sing gegandhengan

Tag produk

katrangan:

Ruifu Chemical Supply Intermediates saka Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino)acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Asam Dietilphosphonoacetic CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-siji CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineCAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineCAS 314771-88-5

Sifat Kimia:

Jeneng Kimia	N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine
sinonim	N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitro-4-Quinazolinamine;(3-Chloro-4-Fluorophenyl)(7-Fluoro-6-Nitroquinazolin-4-yl)amin;4-(3-Chloro-4-Fluoroanilino)-7-Fluoro-6-Nitroquinazoline;Afatinib Intermediate A
Nomer CAS	162012-67-1
Nomer CAT	RF-PI2026
Status Simpenan	Ing Simpenan, Skala Produksi Nganti Ton
Formula Molekul	C14H7ClF2N4O2
Bobot Molekul	336.68
Sensitivitas	Sensitif Udara, Sensitif Panas
Titik Lebur	242.0~244.0 ℃
Titik didih	489 ℃
Kapadhetan	1.616
Merk	Kimia Ruifu

Spesifikasi:

Item	Spesifikasi
Penampilan	Cahya Kuning nganti Bubuk Kuning
Kemurnian / Metode Analisis	> 99,0% (HPLC)
Mundhut ing Pangatusan	<0,50%
Sisa ing Ignition	<0,20%
Zat sing gegandhengan
Najis individu	<0,50%
Total Impurities	<1.00%
Logam abot	≤20ppm
Spektrum Infrared	Conforms kanggo Struktur
Proton NMR Spectrum	Conforms kanggo Struktur
Test Standar	Standar Perusahaan
Panggunaan	Penengah saka Afatinib Dimaleate (CAS: 850140-73-7)

Paket & Panyimpenan:

Paket: Botol, tas Aluminium foil, 25kg / Karton Drum, utawa miturut kabutuhan pelanggan

Kondisi panyimpenan:Simpen ing wadhah sing disegel ing papan sing adhem lan garing;Nglindhungi saka cahya lan Kelembapan

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Aplikasi:

N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine (CAS: 162012-67-1) minangka perantara ing sintesis Afatinib Dimaleate (CAS: 850140-73-7) .Afatinib Dimaleate minangka wangun uyah saka Afatinib.Afatinib minangka inhibitor sing ora bisa dibatalake saka kulawarga ErbB kinase tyrosine.Mekanisme TindakanAfatinib nyuda sinyal ErbB kanthi ikatan kovalen menyang domain kinase saka reseptor faktor pertumbuhan epidermal (EGFR), reseptor faktor pertumbuhan epidermis manungsa (HER) 2 lan HER4, sing nyebabake inhibisi autofosforilasi tyrosine kinase;uga nyegah transphosphorylation saka HER3.Afatinib disetujoni minangka monoterapi kanggo perawatan saka EGFR tyrosine kinase inhibitor (TKI) -naif diwasa kanthi lokal maju utawa DefinitionChEBI: A uyah maleate dijupuk dening nggabungke afatinib karo loro molar padha karo asam maleat.Digunakake kanggo perawatan lini pertama pasien kanker paru-paru non-sel cilik metastatik.