Olopatadine Hydrochloride Intermediate CAS 27710-82-3 Kemurnian >99,0% (HPLC)
Supplier Utama Olopatadine Hydrochloride Intermediates
Olopatadine Hydrochloride CAS 140462-76-6
Isoxepac CAS 55453-87-7
[3-(Dimethylamino)propil]triphenylphosphonium Bromide Hydrobromide CAS 27710-82-3
Please Contact: alvin@ruifuchem.com
| Jeneng Kimia | [3-(Dimethylamino)propil]triphenylphosphonium Bromide Hydrobromide |
| sinonim | (3-Dimethylaminopropyl)triphenylphosphonium Bromide HBr |
| Nomer CAS | 27710-82-3 |
| Nomer CAT | RF2698 |
| Status Simpenan | Ing Simpenan, Skala Produksi Nganti Ton |
| Formula Molekul | C23H28Br2NP |
| Bobot Molekul | 509.27 |
| Titik Lebur | 283.0~285.0 ℃ |
| Stabilitas | Higroskopis |
| Kelarutan | Kloroform (Rada), Metanol (Rada) |
| Merk | Kimia Ruifu |
| Item | Spesifikasi |
| Penampilan | Bubuk Kristal Putih nganti Putih |
| Kemurnian / Metode Analisis | > 99,0% (HPLC) |
| Metode Assay/Analisis | > 99,0% (Titrasi) |
| Mundhut ing Pangatusan | <0,50% |
| Impurity Tunggal | <0,50% |
| Total Impurities | <1.00% |
| 1 H NMR Spektrum | Konsisten karo Struktur |
| Test Standar | Standar Perusahaan |
| Panggunaan | Intermediate Olopatadine Hydrochloride (CAS: 140462-76-6) |
Paket: Botol, tas Aluminium foil, 25kg / Drum Karton, utawa miturut kabutuhan pelanggan
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[3-(Dimethylamino)propyl]triphenylphosphonium Bromide Hydrobromide (CAS: 27710-82-3) minangka perantara Olopatadine Hydrochloride (CAS: 140462-76-6).Olopatadine Hydrochloride minangka obat anti-alergi.Nduweni efek ganda nyandhet pelepasan histamin lan reseptor HI sing selektif antagonis, lan ora duwe inhibisi sistem saraf pusat lan efek samping beracun jantung sing umum karo obat antialergi antagonis reseptor HI.Olopatadine Hydrochloride ora mung bisa nyandhet pelepasan histamin saka sel mast, nanging uga antagonize reseptor H1 luwih selektif, lan ora duwe pengaruh ing reseptor α adrenergik, reseptor dopamin, lan reseptor M1 lan M2.Antarane wong-wong mau, efek samping saka sistem saraf pusat sawetara, iku generasi anyar saka obatan antiallergic pilihan.Olopatadine minangka antagonis selektif sing kuat saka reseptor histamin H1 (Ki = 16-41.1 nM), kanthi afinitas sing luwih murah kanggo reseptor H2 lan H3 (Ki = 43.4 lan 172 μM, masing-masing).Iki ngalangi turnover phosphoinositide sing diakibatake histamin ing sel sing diisolasi (IC50 = 9.5-39.9 nM) lan nyegah anafilaksis kulit pasif ing tikus (ED50 = 49 μg / kg) lan bronkokonstriksi anafilaksis ing marmut (ID50 = 30 μg / kg).Olopatadine efektif kanggo nambani rhinitis alergi lan konjungtivitis.Uga nyuda gatal ing pasien kanthi urtikaria kronis sing dikontrol kanthi apik.Ing manungsa, antihistamin iki ora nyebabake gangguan kognitif utawa psikomotor ing dosis terapeutik.
