Palbociclib CAS 571190-30-2 Kemurnian >99.5% (HPLC) Pabrik API
Ruifu Chemical Supply Palbociclib Related Intermediates:
Palbociclib CAS 571190-30-2
5-Bromo-2,4-Dichloropyrimidine CAS 36082-50-5
5-Bromo-2-Chloro-N-Cyclopentylpyrimidin-4-Amine CAS 733039-20-8
tert-Butil 4-(6-Nitropyridin-3-yl)piperazin-1-Karboksilat CAS 571189-16-7
tert-Butyl 4-(6-Amino-3-Pyridyl)piperazine-1-Carboxylate CAS 571188-59-5
6-Bromo-2-Chloro-8-Cyclopentyl-5-Methylpyrido-[2,3-d]pirimidin-7(8H)-siji CAS 1016636-76-2
2-Chloro-8-Cyclopentyl-5-Methyl-8H-Pyrido[2,3-d]pirimidin-7-siji CAS 1013916-37-4
Jeneng Kimia | Palbociclib |
sinonim | PD-0332991;Otava-Bb 1115529;Ibrance |
Nomer CAS | 571190-30-2 |
Status Simpenan | Ing Simpenan, Skala Produksi Nganti Ton |
Formula Molekul | C24H29N7O2 |
Bobot Molekul | 447.54 |
Merk | Kimia Ruifu |
Item | Spesifikasi |
Penampilan | Bubuk Putih utawa Off-White |
Spektrum 1H NMR | Konsisten karo Struktur |
HPLC | Konsisten karo Struktur |
Zat sing gegandhengan | |
Najis individu | <0,50% |
Total Impurities | <1.00% |
Mundhut ing Pangatusan | <0,50% |
Sisa ing Ignition | <0,10% |
Logam abot | <10 ppm |
Kemurnian / Metode Analisis | > 99,5% (HPLC) |
Test Standar | Standar Perusahaan |
Panggunaan | API, Ing Perawatan Kanker Payudara |
Paket: Botol, tas Aluminium foil, 25kg / Karton Drum, utawa miturut kabutuhan pelanggan
Kondisi panyimpenan:Simpen ing wadhah sing disegel ing papan sing adhem lan garing;Nglindhungi saka cahya lan Kelembapan
Palbociclib (CAS: 571190-30-2) minangka inhibitor kinase gumantung cyclin (CDK) sing kasedhiya kanthi lisan kanthi aktivitas antineoplastik sing potensial.Palbociclib selektif nyandhet kinase 4 (CDK4) lan 6 (CDK6) sing gumantung karo cyclin, saéngga nyegah fosforilasi protein retinoblastoma (Rb) ing awal fase G1 sing nyebabake penahanan siklus sel.Iki nyuda replikasi DNA lan nyuda proliferasi sel tumor.Palbociclib minangka wakil pisanan saka kelas obat anyar saka inhibitor kinase sing gumantung karo cyclin.Efek iki mbatesi proliferasi sel (tuwuh lan divisi sel).Iki digunakake minangka agen antineoplastik ing kanker payudara lanjut utawa metastatik.