(R)-(-)-3-Pyrrolidinol Hydrochloride CAS 104706-47-0 Purity ≥99.7% (GC) Kiral Purity ≥99.7% Panipenem and Darifenacin hydrobromide Intermediate
Pasokan Produsen;High Purity lan Rega Kompetitif
Shanghai Ruifu Chemical Co., Ltd. Senyawa Kiral Pasokan Komersial:
(R)-(-)-3-Pyrrolidinol Hydrochloride CAS: 104706-47-0
(S)-3-Hydroxypyrrolidine hydrochloride CAS: 122536-94-1
Intermediate Panipenem (CAS 87726-17-8) lan Darifenacin hydrobromide (CAS 133099-07-7)
| Jeneng Kimia | (R)-(-)-3-Pyrrolidinol Hydrochloride |
| sinonim | (R)-(-)-3-Hydroxypyrrolidine Hydrochloride;(R)-(-)-3-Hydroxypyrrolidine-HCl |
| Nomer CAS | 104706-47-0 |
| Nomer CAT | RF-CC102 |
| Kemurnian / Metode Analisis | ≥98,0% (GC) |
| Status Simpenan | Ing Simpenan, Skala Produksi Nganti Ton |
| Formula Molekul | C4H10ClNO |
| Bobot Molekul | 123.58 |
| Titik Lebur | 107.0 ~ 111.0 °C |
| Kelarutan ing banyu | Meh Transparansi |
| Merk | Kimia Ruifu |
| Item | Spesifikasi |
| Penampilan | Bubuk Kristal Putih nganti Coklat Pucat |
| Kemurnian / Metode Analisis | ≥99,7% (GC) |
| Kemurnian Kiral | ≥99,7% ee |
| Sisa ing Ignition | ≤0,50% |
| Rotasi Spesifik [α]D20 | -6,5°~ -8,5° (C=3,5 CH3OH) |
| Sembarang Najis Individu | ≤0,20% |
| Total impurities | ≤0,30% |
| Test Standar | Standar Perusahaan |
| Panggunaan | Penengah Farmasi;Senyawa kiral |
Metode Analisis
Peralatan: Instrumen GC (Shimadzu GC-2010)
Kolom: DB-17 Agilent 30mX0.53mmX1.0μm
Suhu oven wiwitan: 80 ℃
Wektu wiwitan 2.0 min
Tingkat 15 ℃ / min
Suhu oven pungkasan: 250 ℃
Wektu pungkasan 20 menit
Gas pembawa Nitrogen
Mode aliran konstan
Aliran 5.0mL / min
Rasio pamisah 10:1
Suhu injector: 250 ℃
Suhu detektor: 300 ℃
Volume injeksi 1,0 μL
Pancegahan sing kudu ditindakake sadurunge analisis:
1. Kondisi kolom ing 240 ℃ kanggo minimal 30minutes.
2. Cuci syringe lan resik injector liner mlaku kanggo mbusak rereged saka analisis sadurungé.
3. Wisuh, garing lan isi diluent ing syringe wisuh vials.
Preparation diluent:
Siapke 2% w/v larutan natrium hidroksida ing banyu.
Persiapan standar:
Timbang kira-kira 100mg standar (R)-3-hydroxyprrolidine hydrochloride menyang vial, tambahake 1mL diluent lan larut.
Persiapan tes:
Timbang kira-kira 100mg sampel tes menyang vial, tambahake 1mL diluent lan larut.Siapke ing duplikat.
tata cara:
Nyuntikake kothong (pengencer), persiapan standar lan persiapan tes nggunakake kondisi GC ing ndhuwur.Abaikan puncak amarga kosong.Wektu retensi puncak amarga (R)-3-hydroxyprrolidine kira-kira 5.0min.
Cathetan:
Laporan asil minangka rata-rata
Paket: Botol, tas Aluminium foil, Drum karton, 25kg / Drum, utawa miturut kabutuhan pelanggan.
Kondisi panyimpenan:Simpen ing wadhah sing disegel ing papan sing adhem lan garing;Nglindhungi saka cahya, kelembapan lan infestasi hama.
Shanghai Ruifu Chemical Co., Ltd. minangka produsen lan pemasok utama (R)-(-)-3-Pyrrolidinol Hydrochloride (CAS: 104706-47-0) kanthi kualitas dhuwur, digunakake ing sintesis organik, sintesis intermediet farmasi lan sintesis Active Pharmaceutical Ingredient (API).
(R)-(-)-3-Pyrrolidinol Hydrochloride (CAS: 104706-47-0) minangka perantara biasane ing sintesis Panipenem (CAS 87726-17-8) lan Darifenacin hydrobromide (CAS 133099-07-7).
(R)-(-)-3-Pyrrolidinol Hydrochloride (CAS: 104706-47-0) minangka turunan hidroksi kiral saka pyrrlodine sing digunakake kanggo nyiapake senyawa aktif kiral kayata antagonis reseptor muskarinik lan agen antimikroba.
Rute Sintesis (R)-3-Hydroxypyrrolidine hydrochloride
(R) -4-chloro-3-hydroxybutanitrile direaksikake karo trimetil klorosilan ing pelarut diklorometana kanggo entuk (R) -4-chloro-3-trimethylsiloxy butanitrile.(R) -4-chloro-3-trimethylsiloxyebutylamine banjur dihidrogenasi ing katalis Pd / C. (R) -3-trimethylsiloxyepyrrolidine diduweni dening perawatan nutup cincin natrium hidroksida.Pungkasan, produk (R) -3-hydroxypyrrolidine hidroklorida dipikolehi kanthi perawatan asam hidroklorat pekat lan gugus protèktif trimethylsilyl dibusak.
