trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7 Kemurnian >98,0% (HPLC) Afatinib Dimaleate Intermediate

Katrangan singkat:

trans-4-Dimethylaminocrotonic Acid Hydrochloride

CAS: 848133-35-7

Kemurnian: >98,0% (HPLC)

Penampilan: Bubuk putih nganti meh putih

Penengah saka Afatinib Dimaleate (CAS: 850140-73-7)

Kontak: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

Kirimi email kanggo kita

Detail Produk

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katrangan:

Ruifu Chemical Supply Intermediates saka Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino)acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Asam Dietilphosphonoacetic CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-siji CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineCAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineCAS 314771-88-5

Sifat Kimia:

Jeneng Kimia	trans-4-Dimethylaminocrotonic Acid Hydrochloride
sinonim	trans 4-Dimethylaminocrotonic Acid HCl;(E)-4-(Dimethylamino)-2-Butenoic Acid Hydrochloride;(E)-4-Dimethylaminocrotonic Acid Hydrochloride;(2E)-4-(Dimethylamino)nanging-2-Enoic Acid Hydrochloride;Afatinib int-2
Nomer CAS	848133-35-7
Status Simpenan	Ing Simpenan, Skala Komersial
Formula Molekul	C6H12ClNO2
Bobot Molekul	165.62
Sensitivitas	Higroskopis.Kelembapan Sensitif
Titik Lebur	160,0 kanggo 164,0 ℃
Kelarutan	DMSO (Rada), Metanol (Rada), Banyu (Rada)
COA & MSDS	kasedhiya
asale	Shanghai, China
Merk	Kimia Ruifu

Spesifikasi:

Item	Spesifikasi
Penampilan	Bubuk putih nganti meh putih
Kemurnian / Metode Analisis	> 98,0% (HPLC)
Kemurnian / Metode Analisis	> 98,0% (NMR)
Kelembapan (KF)	<0,50%
Sisa ing Ignition	<0,20%
Impurity Tunggal	<0,50%
Logam Berat (Pb)	<20 ppm
Spektrum Infrared	Conforms kanggo Struktur
1 H NMR Spektrum	Proton NMR Spectrum
Test Standar	Standar Perusahaan
Panggunaan	Penengah saka Afatinib, Afatinib Dimaleate

Paket & Panyimpenan:

Paket:Botol, tas Aluminium foil, 25kg / Drum Karton, utawa miturut kabutuhan pelanggan.

Kondisi panyimpenan:Simpen ing wadhah sing disegel ing papan sing adhem lan garing;Nglindhungi saka cahya lan Kelembapan.

Pengiriman:Ngirim menyang donya liwat udhara, dening FedEx / DHL Express.Nyedhiyakake pangiriman sing cepet lan dipercaya.

Kemurnian kromatografi:

Instrumen: Agilent 1200 HPLC HPLC kromatografi, DAD detector.
Kolom: Agilent XDB-C18,250*4.6mm, 5μm
Fase gerak: B: 1.95g natrium oktan sulfonat + 8ml asam fosfat + 5ml trietilamin + 500ml banyu
C: asetonitril
Preparation of mixed mobile phase: njupuk 400ml solusi B lan 100ml acetonitrile, nyampur sak tenane lan roto-roto, lan pump Cairan ing siji phase.
Tingkat aliran: 0,5ml / min54bar
Suhu kolom: 25 ℃
Dawane gelombang: 210nm
Solusi sampel: fase gerak digunakake minangka pelarut, sampel padat: 0,0040g/2ml, ukuran sampel 2,0μl.

Kaluwihan:

FAQ:

Aplikasi:

trans-4-Dimethylaminocrotonic Acid Hydrochloride (CAS: 848133-35-7) minangka reagen sing digunakake kanggo nyiapake agen antitumor tirosin kinase.trans-4-Dimethylaminocrotonic Acid Hydrochloride bisa digunakake minangka perantara saka Afatinib (CAS: 439081-18-2), Afatinib Dimaleate (CAS: 850140-73-7), Neratinib (CAS: 698387-09-6).Afatinib minangka obat sing disetujoni kanggo perawatan karsinoma paru-paru non-sel cilik (NSCLC), sing dikembangake dening Boehringer Ingelheim.Iku tumindak minangka inhibitor angiokinase.Kaya Lapatinib lan Neratinib, Afatinib minangka inhibitor tyrosine kinase (TKI) sing uga nyegah reseptor faktor pertumbuhan epidermal manungsa 2 (Her2) lan reseptor faktor pertumbuhan epidermis (EGFR) kinase.Afatinib ora mung aktif marang EGFRmutasi sing ditargetake dening TKI generasi pertama likeerlotinib utawa gefitinib, nanging uga marang sing ora sensitif marang terapi standar kasebut.Amarga aktivitas tambahan marang Her2, lagi diselidiki kanggo kanker payudara uga kanker EGFR lan Her2 liyane.Neratinib dikembangake dening perusahaan US Wyeth minangka inhibitor reseptor faktor pertumbuhan epidermal (EGFR) sing ora bisa dibatalake.Iki minangka titik target kaping pirang-pirang inhibitor tirosin kinase molekul cilik menyang HER 2 lan HER1 sawise Lapatinib, lan minangka inhibitor tirosin kinase reseptor ErbB sing ora bisa dibatalake.Neratinib bisa selektif nyandhet HER-1 lan HER-2 saka kulawarga EGFR (IC50 yaiku 92 nmol/L lan 59 nmol/L, masing-masing).Riset klinis nuduhake yen Neratinib nduwe pengaruh terapeutik sing signifikan marang kanker paru-paru non-sel cilik, kanker usus besar, lan kanker payudara.Uji coba klinis faseⅡ nunjukake yen Neratinib nuduhake khasiat lan toleransi sing apik kanggo pasien positif HER-2 kanthi kanker payudara lanjut sing wis ditampa utawa ora perawatan Trastuzumab.Uji klinis kanker payudara tahap Ⅲ rampung ing September 2014.