Asam Zoledronic CAS 118072-93-8 Kemurnian ≥99.7% Pabrik API Kualitas Tinggi
Pasokan kanthi Kemurnian Tinggi lan Kualitas Stabil
Jeneng Kimia: Zoledronic Acid
CAS: 118072-93-8
Potent Farnesyl Diphosphate (FPP) Synthase Inhibitor
API Kualitas Tinggi, Produksi Komersial
| Jeneng Kimia | Asam Zoledronic |
| sinonim | ZOL 446, ZA, Zoledronate, CGP-4244, GP42446A, Zometa, Zomera;[1-Hydroxy-2-(1H-imidazol-1-yl)-ethylidene]asam bifosfonik |
| Nomer CAS | 118072-93-8 |
| Nomer CAT | RF-API90 |
| Status Simpenan | Ing Stok, Skala Produksi Nganti Atusan Kilogram |
| Formula Molekul | C5H10N2O7P2 |
| Bobot Molekul | 272.09 |
| Titik Lebur | 193.0~204.0 ℃ |
| Merk | Kimia Ruifu |
| Item | Spesifikasi |
| Penampilan | Bubuk Kristal Putih nganti Putih |
| Identifikasi | Spektrum IR saka sampel cocog karo standar referensi |
| pH | 2.0~4.0 |
| Kelarutan | Larut ing 0.1N Sodium Hydroxide Solution, Rada Larut ing Banyu lan 0.1N Hydrochloric Acid, Praktis ora larut ing Etanol |
| Zat sing gegandhengan | |
| Sembarang Najis Individu | ≤0,10% |
| Total Impurities | ≤0,30% |
| Mundhut ing Pangatusan | 5,0%~7,0% |
| klorida | ≤0,02% |
| fosfat | ≤0,50% |
| fosfat | ≤0,50% |
| Logam abot | ≤10ppm |
| Kemurnian | ≥99,7% |
| Test Standar | Standar Perusahaan |
| Panggunaan | API, FPP Synthase Inhibitor, Hypercalcemia of Malignancy (HCM) |
Paket: Botol, tas Aluminium foil, Drum karton, 25kg / Drum, utawa miturut kabutuhan pelanggan.
Kondisi panyimpenan:Simpen ing wadhah sing disegel ing papan sing adhem lan garing;Nglindhungi saka cahya, kelembapan lan infestasi hama.
Asam Zoledronic (CAS 118072-93-8) minangka inhibitor sintase bisphophonate farnesyl diphosphate (FPP) sing kuat (IC50=20 nM).Nyandhet resorpsi balung sing dimediasi osteoklas.Uga nyegah sinyal Ras lan wutah tumor, lan ngindhuksi apoptosis ing sel kanker pankreas.Mbalikake transisi epitelial-mesenchymal lan nyegah pembaharuan sel kanker payudara liwat inaktivasi NF-κB.Asam Zoledronic disetujoni dening FDA AS ing taun 2001 kanggo perawatan hiperkalsemia ganas, komplikasi metabolik sing bisa ngancam nyawa.Hiperkalsemia ganas bisa kedadeyan nganti 50% pasien sing didiagnosis kanker payudara lanjut, multiple myeloma, lan kanker paru-paru sel non-small.Kondisi iki muncul nalika molekul kimia sing diprodhuksi dening tumor nyebabake overstimulasi osteoklas.Nalika ana paningkatan degradasi balung, ana pelepasan kalsium sing bebarengan menyang plasma.Nalika konsentrasi kalsium serum mundhak kanthi cepet, ginjel ora bisa ngatasi kakehan, lan nyebabake hiperkalsemia.Asam Zoledronic kanthi efektif nyuda konsentrasi kalsium plasma liwat inhibisi resorpsi balung (inhibisi aktivitas osteoklastik lan induksi apoptosis osteoklas).Kajaba iku, asam zoledronic wis disetujoni dening FDA AS kanggo perawatan macem-macem myeloma lan metastase balung sing ana gandhengane karo kanker adhedhasar tumor padhet (contone, sujud lan paru-paru).
