L-Alanine CAS 56-41-7 (H-Ala-OH) Purity 98.5%~101.0% AJI 97/USP/BP/FCC Standard
Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of L-Alanine (H-Ala-OH) (Abbreviated Ala or A) (CAS: 56-41-7) with high quality, production capacity 20000 tons per year, meets AJI 97/USP/BP/JP/FCC specifications. Ruifu Chemical is one of the largest suppliers of L-Alanine in China, has a large market share. L-Alanine is sold well both at domestic and abroad market, praised by the majority of customers. Ruifu Chemical also supplys other amino acids and derivatives. We can provide COA, worldwide delivery, small and bulk quantities available. If you are interested in L-Alanine, Please contact: alvin@ruifuchem.com
| Chemical Name | L-Alanine |
| Synonyms | H-Ala-OH; L-Ala; L-(+)-Alanine; (Abbreviated Ala or A); L-α-Alanine; (S)-2-Aminopropanoic Acid; L-2-Aminopropionic Acid; L-Alpha-Alanine; (2S)-2-Aminopropanoic Acid; (S)-2-Aminopropanoic Acid; (S)-(+)-Alanine; (S)-Alanine; L-α-Aminopropionic Acid; α-Alanine; α-Aminopropionic Acid |
| CAS Number | 56-41-7 |
| CAT Number | RFA101 |
| Stock Status | In Stock, Production Capacity 20000 Tons per Year |
| Molecular Formula | C3H7NO2 |
| Molecular Weight | 89.09 |
| Melting Point | 315℃ |
| Density | 1.432 g/cm3 |
| Solubility in Water | Almost Transparency |
| Stability | Stable. Incompatible With Strong Oxidizing Agents |
| Brand | Ruifu Chemical |
| Hazard Codes | Xi | F | 10 |
| Risk Statements | 36/37/38 | TSCA | Yes |
| Safety Statements | 24/25-36-26 | Hazard Class | Irritant |
| WGK Germany | 3 | HS Code | 2922491990 |
| RTECS | AY2990000 |
| Item | Specifications |
| Appearance | White Crystal or Crystalline Powder; Slight Sweet Taste |
| Purity | 98.5%~101.0% (Calculated on the dried basis) |
| Identification | Compare the infrared absorption spectrum of the sample with that of the standard by potassium bromide disc method |
| Solubility | Freely soluble in water and in formic acid, practically insoluble in ethanol and in ether. Dissolves in dilute hydrochloric and in dilute sulfuric acid. |
| Specific Rotation [α]D20 | +14.3° ~ +15.2° (C=10,6N HCl) |
| State of Solution | Clear and Colorless |
| Transmittance | ≥98.0% |
| Chloride (Cl) | ≤0.010% |
| Ammonium (NH4) | ≤0.020% |
| Sulfate (SO4) | ≤0.020% |
| Iron (Fe) | ≤10ppm |
| Heavy Metals (Pb) | ≤10ppm |
| Arsenic (AS2O3) | ≤1ppm |
| Other Amino Acids | Conforms |
| Loss on drying | ≤0.20% (Dry it at 105℃ for 3 hours) |
| Residue on Ignition | ≤ 0.10% |
| Mesh | 90% Pass 40-60 Mesh |
| Other Amino Acids | Chromatographically Not Detectable |
| pH Value | 5.5~7.0 |
| Test Standard | AJINOMOTO Amino Acid Specifications 8th Edition (AJI 97) Food Chemicals Codex Twelfth Edition (FCC) United States Pharmacopoeia (USP) |
| Usage | Amino Acids; Food Additives; Pharmaceutical Intermediates |
The whole Manufacturing Process of L-Alanine
(H-Ala-OH) (Abbreviated Ala or A) (CAS: 56-41-7)
DEFINITION
Alanine contains NLT 98.5% and NMT 101.5% of C3H7NO2, as L-alanine, calculated on the dried basis.
IDENTIFICATION
INFRARED ABSORPTION <197K>
ASSAY
PROCEDURE
Sample:80 mg of Alanine
Titrimetric system USP L-Alanine RS (See Titrimetry <541>)
Mode: Direct titration
Titrant: 0.1 N perchloric acid VS
Endpoint detection:Potentiometric
Blank: 3 mL of formic acid in 50 mL of glacial acetic.acid
Analysis: Dissolve the Sample in a mixture of 3 mL of formic acid and 50 mL of glacial acetic acid, and titrate with 0.1 N perchloric acid VS. Calculate the percent age of C3H7NO2 in the portion taken:
Result = [(V-B) xNxFx100]/W
V= Sample titrant volume (mL)
B= Blank titrant volume (mL)
N= titrant normality (mEq/mL)
F= equivalency factor: 89.09 mg/mEq
W= weight of the Sample (mg)
Acceptance criteria: 98.5%–101.5% on the dried basis
IMPURITIES
Inorganic Impurities
RESIDUEON IGNITION <281>: NMT 0.15%
CHLORIDEAND SULFATE, Chloride <221>: A 1.0-g portion shows no more chloride than corresponds to 0.70 mL of 0.020 N hydrochloric acid (0.05%).
CHLORIDEAND SULFATE, Sulfate <221>: A 1.0-g portion shows no more sulfate than corresponds to 0.30 mL of Impurities.0.020 N sulfuric acid (0.03%).
IRON <241>: NMT 30 ppm
HEAVY METALS, Method I <231>: NMT 15 ppm
Organic Impurities
PROCEDURE
Adsorbent: 0.25-mm layer of chromatographic silica gel mixture
Standard solution: 0.05 mg/mL of USP L-Alanine RS. [NOTE—This solution has a concentration equivalent to 0.5% of that of the Sample solution.]
System suitability solution: 0.4 mg/mL each of USP L-Alanine RS and USP Glycine RS
Sample solution: 10 mg/mL of Alanine
Spray reagent: 2 mg/mL of ninhydrin in a mixture of butyl alcohol and 2 N acetic acid (95:5)
Developing solvent system:Butyl alcohol, glacial acetic acid, and water (60:20:20)
Application volume:5μL
Analysis
Samples: Standard solution, System suitability solution, and Sample solution
Proceed as directed for Chromatography <621>, Thin-Layer Chromatography. After air-drying the plate, repeat the development process. After air-drying a second time, spray with Spray reagent, and heat to.100~105 for 15 min. Examine the plate underwhite light. The chromatogram obtained from the System suitability solution exhibits two clearly sepa-rated spots.
Acceptance criteria
Individual impurities: Any secondary spot of the Sample solution is not larger or more intense than the principal spot of the Standard solution, NMT 0.5%
Total impurities: NMT 2.0%
SPECIFIC TESTS
OPTICAL ROTATION, Specific Rotation <781S>: +13.7° to +15.1° Sample solution:100 mg/mL in 6 N hydrochloric acid
PH <791>: 5.5~7.0, in a solution (1 in H20)
LOSSON ON DRYING <731>: Dry a sample at 105℃ for 3 h: it loses NMT 0.2% of its weight.
ADDITIONAL REQUIREMENTS
PACKAGINGAND STORAGE: Preserve in tight containers, and store at controlled room temperature.
USP REFERENCE STANDARDS <11>
USP L-Alanine RS
USP Glycine RS
Package: Bottle, 25kg/Bag, 25kg/Cardboard drum, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool, dry and ventilated warehouse away from incompatible substances. Protect from light and moisture.
L-Alanine (symbol Ala or A, CAS 56-41-7) is an α-amino acid that is used in the biosynthesis of proteins. L-Alanine is one of the 20 amino acids encoded by the genetic code. It contains an amine group and a carboxylic acid group, both attached to the central carbon atom which also carries a methyl group side chain.
L-Alanine (CAS 56-41-7) is widely used as nutrition supplements, as sweetener and flavor enhancer in the food industry, as flavor enhancer and preservative in the beverage industry, as intermediate for medicine manufacturing in pharmaceutical, as nutritional supplement and sour corrective agent in agriculture/animal feed, and as intermediate in manufacturing of various organic chemicals. L-Alanine is an amino acid that can act as a skin-conditioning agent. It is usually used in combination with other amino acids.
L-Alanine is the L-enantiomer of alanine. L-alanine is utilized in clinical nutrition as a component for parenteral and enteral nutrition. L-alanine plays a key role in transferring nitrogen from tissue sites to the liver. L-Alanine is widely used as nutrition supplements, as sweetener and flavor enhancer in the food industry, as flavor enhancer and preservative in the beverage industry, as intermediate for medicine manufacturing in pharmaceutical, as nutritional supplement and sour corrective agent in agriculture/animal feed, and as intermediate in manufacturing of various organic chemicals.
