L-Cysteine Hydrochloride Monohydrate CAS 7048-04-6 Assay 98.5~101.0% (Titration on Dried Basis) Factory

Short Description:

Chemical Name: L-Cysteine Hydrochloride Monohydrate

Synonyms: H-Cys-OH·HCl Monohydrate 

CAS: 7048-04-6

Assay: 98.5~101.0% (Titration on Dried Basis) 

White Crystals or Crystalline Powder, Strongly Acid Taste

Amino Acid Derivative, High Quality, Non-Animal Origin

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


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Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of L-Cysteine Hydrochloride Monohydrate (H-Cys-OH·HCl·H2O) (CAS: 7048-04-6) with high quality. As one of the largest amino acids suppliers in China, Ruifu Chemical manufactures qualified amino acids derivatives up to international standards, such as AJI , USP, EP, GB, and FCC standard. We can provide COA, worldwide delivery, small and bulk quantities available. If you are interested in L-Cysteine Hydrochloride Monohydrate, Please contact: alvin@ruifuchem.com

Chemical Properties:

Chemical Name L-Cysteine Hydrochloride Monohydrate 
Synonyms H-Cys-OH·HCl; H-Cys-OH·HCl Monohydrate; H-Cys-OH·HCl·H2O; L-Cys-OH·HCl·H2O; L-Cysteine HCL Monohydrate; L-Cysteine HCl H2O; (R)-2-Amino-3-Mercaptopropanoic Acid Hydrochloride Monohydrate; LCHCMH
Stock Status In Stock, Production Capacity 3000 Tons per Year 
CAS Number 7048-04-6 
Molecular Formula C3H10ClNO3S
Molecular Weight 175.64 (157.62 anhy)
Melting Point 175.0~178.0℃ 
Density 1.54 g/cm3 
Sensitive Hygroscopic. Air Sensitive, Light Sensitive, Moisture Sensitive
Water Solubility  Very Soluble in Water 
Storage Temp.  Sealed in Dry, Store at Room Temperature
COA & MSDS Available
Classification Amino Acid Derivatives
Brand Ruifu Chemical

Safety Information:

Hazard Codes Xi   RTECS                        HA2285000                                 
Risk Statements 36/37/38  F    3-10-23  
Safety Statements 26-36                              TSCA  Yes
WGK Germany HS Code           2922491990                        

Specifications:

Items Inspection Standards Results
Appearance White Crystals or Crystalline Powder, Strongly Acid Taste Conforms          
Identification Infrared Absorption Spectrum Conforms
Specific Rotation [α]20/D +6.1° to +7.8°(C=8,1N HCl)
+6.3°
State of Solution (Transmittance) Clear and Colorless ≥98.0% 99.1%
Chloride (Cl) 19.89 to 20.29% 20.16%
Sulfate (SO4) ≤0.020% <0.020%
Ammonium (NH4) ≤0.020% <0.020%
Iron (Fe) ≤10ppm <10ppm 
Heavy Metals (Pb) ≤10ppm <10ppm 
Arsenic (As2O3) ≤1.0ppm <1.0ppm
Other Amino Acids Chromatographically Not Detectable  Conforms
Loss on Drying 8.5 to 12.0% 9.3%
Residue on Ignition (Sulfated) ≤0.10%  0.06%
Assay 98.5 to 101.0% (Titration:  on Dried Basis)     99.8%
pH Test  1.5 to 2.0 (1% in Water)  1.8
Origin Non-Animal Source Conforms
Residual Solvents Conforms Conforms
Conclusion This Product by Inspection Accords with the Standard of AJI97
Main Uses Amino Acids; Food Additives; Pharmaceutical Intermediates

Package & Storage:

Package: Fluorinated Bottle, 25kg/bag, 25kg/Cardboard Drum, or according to customer's requirement.

Storage Condition: Store in sealed containers at cool, dry and ventilated warehouse away from incompatible substances. Protect from light and moisture.

7048-04-6 Test Methods:

L-Cysteine Hydrochloride Monohydrate (CAS: 7048-04-6) AJI97 Test Method
Identification: Compare the infrared absorption spectrum of the sample with that of the standard by potassium bromide disc method.
Specific Rotation [α]D20: Dried sample, C=8, 1mol/L HCl
State of Solution (Transmittance): 1.0g in 10ml of H2O, spectrophotometer, 430nm, 10mm cell thickness.
Chloride (Cl): 350mg, B-2
Ammonium (NH4): A-1
Sulfate (SO4): 1.2g, (1), ref: 0.50ml of 0.005mol/L H2SO4
Iron (Fe): 1.5g, ref: 1.5ml of Iron Std. (0.01mg/ml)
Heavy Metals (Pb): 2.0g, (1), pH=7, ref: 2.0ml of Pb Std. (0.01mg/ml)
Arsenic (As2O3): 2.0g, (1), ref: 2.0ml of As2O3 Std.
Other Amino Acids: Test Sample: 50μg, B-6-a, control; L-Cys·HCl·H2O 0.25μg
Loss on Drying: In vacuum, P2O5, at room temperature for 20 hours.
Residue on Ignition (Sulfated): AJI Test 13
Assay: Dried sample, 250mg, 0.05mol/L I2 1ml=15.762mg C3H7NO2S·HCl
pH Test: 1.0g in 100ml of H2O

L-Cysteine Hydrochloride Monohydrate (CAS: 7048-04-6) USP35 Test Method
DEFINITION
Cysteine Hydrochloride is L-Cysteine Hydrochloride Monohydrate and contains NLT 98.5% and NMT 101.5% of L-Cysteine Hydrochloride (C3H7NO2S·HCl), calculated on the dried basis.
IDENTIFICATION
A. INFRARED ABSORPTION <197K>
ASSAY
PROCEDURE
Sample: 250 mg of Cysteine Hydrochloride
Blank: Proceed as directed in the Analysis without the Sample.
Titrimetric system
(See Titrimetry <541>)
Mode: Residual titration
Titrant: 0.1 N iodine VS
Back titrant: 0.1 N sodium thiosulfate VS
Endpoint detection: Visual
Analysis: Transfer the Sample to an iodine flask. Add 20.0 mL of water and 4 g of potassium iodide, and mix. Cool the solution in an ice bath, and add 5 mL of 3 N hydrochloric acid and 25.0 mL of 0.1 N iodine VS. Insert the stopper, and allow to stand in the dark for 20 min. Titrate the excess iodine with the Back titrant. Add 3 mL of star ch TS as the endpoint is approached. Per form the Blank determination. Calculate the percentage of cysteine hydrochloride (C3H7NO2S·HCl) in the Sample taken:
Result = {[(VB − VS) × N × F]/W} × 100
VB = Back titrant volume consumed by the Blank (mL)
VS = Back titrant volume consumed by the Sample (mL)
N = actual normality of the Back titrant (mEq/mL)
F= equivalency factor, 157.6 mg/mEq
W= Sample weight (mg)
Acceptance criteria: 98.5%~101.5% on the dried basis
IMPURITIES
RESIDUEON ON IGNITION <281>: NMT 0.4%
CHLORIDE AND SULFATE, Sulfate <221>
Standard solution: 0.10 mL of 0.020 N sulfuric acid
Sample: 0.33 g of Cysteine Hydrochloride
Acceptance criteria: NMT 0.03%
IRON <241>: NMT 30ppm
HEAVY METALS, Method I <231>: NMT 15ppm
RELATED COMPOUNDS
N-Ethylmaleimide solution: 40 mg/mL of N-ethylmaleimide in alcohol
Standard stock solution: Dissolve 20 mg of USP L-Cysteine Hydrochloride RS in 10.0 mL of water. Add 10.0 mL of N-Ethylmaleimide solution, and mix. Allow the solution to stand for 5 min before using.
Standard solution: 0.05 mg/mL from Standard stock solution in water. [ NOTE-This solution has a concentration equivalent to 0.5% of that of the Sample solution.]
System suitability solution: Transfer 10 mg of USP L-Tyrosine RS and 10 mL of the Standard stock solution to a 25-mL volumetric flask. Dilute with water to volume.
Sample stock solution: Transfer 0.2 g of Cysteine Hydrochloride to a 10-mL volumetric flask, dissolve, and dilute with water to volume.
Sample solution: To 5.0 mL of the Sample stock solution add 5.0 mL of N-Ethylmaleimide solution, and mix. Allow the solution to stand for 5 min before using.
Chromatographic system (See Chromatography <621>, Thin-Layer Chromatography.)
Mode: TLC
Adsorbent: 0.25-mm layer of chromatographic silica gel mixture
Application volume: 5μL
Developing solvent system: Butyl alcohol, glacial acetic acid, and water (3:1:1)
Spray reagent: 2 mg/mL of ninhydrin in a mixture of butyl alcohol and 2N acetic acid (95:5)
System suitability
Suitability requirements: The chromatogram of the System suitability solution exhibits two clearly separated spots.
Analysis
Samples: Standard solution, System suitability solution, and Sample solution.
After air-drying the plate, spray with Spray reagent, and heat between 100° and 105° for 15 min. Examine the plate under white light.
Acceptance criteria: Any secondary spot of the Sample solution is not larger or more intense than the principal spot of the Standard solution.
Individual impurities: NMT 0.5%
Total impurities: NMT 2.0%
SPECIFIC TESTS
OPTICAL ROTATION, Specific Rotation <781S>
Sample solution: 80 mg/mL in 6 N hydrochloric acid
Acceptance criteria: +5.7° to +6.8°
LOSSON DRYING <731>: Dry a sample at room temperature at a pressure not exceeding 5 mm of mer cury for 24 h: it loses 8.0%~12.0% of its weight.
ADDITIONAL REQUIREMENTS
PACKAGING AND STORAGE: Preserve in well-closed containers.
USP REFERENCE STANDARDS <11>
USP L-Cysteine Hydrochloride RS
USP L-Tyrosine RS

Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock    

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality AssuranceStrict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

SamplesMost products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory AuditFactory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

TransportationBy Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom SynthesisCan provide custom synthesis services to best fit your research needs.

Payment TermsProforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc. 

Application:

L-Cysteine Hydrochloride Monohydrate (H-Cys-OH·HCl·H2O) (CAS: 7048-04-6) is a water-soluble salt of the non-essential amino acid L-cysteine. It is widely used in fields of medicine, food processing, nutritional supplement, antioxidant, color retention agent, biological study, materials of chemical industry and so on. It is a promotor for bread fermentation. It promotes the form of glutelin and prevents from getting ageing. Also used in cosmetic. It is used in natural fruit juice for preventing Vitamin C oxide. It has a detoxification for poison of acrylonitrile aromafic acid. It is used for protecting against radiation harm and therapy of bronchitis and liquefy sputum. L-Cysteine Hydrochloride Monohydrate is mainly used in the field of Medicine: the drug produced can treat leukopenia and leukopenia caused by the administration of anticancer drugs and radioactive drugs clinically. It is an antidote to heavy metal poisoning. It is also used to treat toxic hepatitis, thrombocytopenia, skin ulcer, prevent liver necrosis, and has the effects of treating tracheitis and expectoration. Food grade: nutritional supplement, antioxidants. Bread amendment, promote fermentation, prevent oxidation. In food aspects, as bread crash accelerator, can change the bread and the food flavor. It's hygroscopic. Slow oxidation and decomposition in air. Very soluble in water.

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