L-Hydroxyproline CAS 51-35-4 (H-Hyp-OH) Assay 98.5~101.0% Factory

Short Description:

Chemical Name: L-Hydroxyproline

Synonyms: H-Hyp-OH; trans-4-Hydroxy-L-Proline

CAS: 51-35-4

Assay: 98.5~101.0% 

Appearance: White Crystals or Crystalline Powder

Unusual Amino Acids, High Quality 

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


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Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of L-Hydroxyproline (H-Hyp-OH) (CAS: 51-35-4) with high quality. Ruifu Chemical supplys a series of amino acids and derivatives. We can provide worldwide delivery, small and bulk quantities available. Purchase L-Hydroxyproline, Please contact: alvin@ruifuchem.com

Chemical Properties:

Chemical Name L-Hydroxyproline 
Synonyms H-Hyp-OH; trans-4-Hydroxy-L-Proline; H-L-Hyp-OH; H-trans-Hyp-OH; L-Hyp-OH; trans-L-4-Hydroxyproline; (2S,4R)-4-Hydroxypyrrolidine-2-Carboxylic Acid
Stock Status In Stock, Production Capacity 35 Tons per Month
CAS Number 51-35-4
Molecular Formula C5H9NO3
Molecular Weight 131.13 g/mol
Melting Point 273℃(dec.)(lit.)
Sensitive Air Sensitive 
Solubility in Water  Almost Transparency  
Storage Temp.  Cool & Dry Place (≤25℃) 
COA & MSDS Available
Category   Unusual Amino Acids  
Brand Ruifu Chemical

Specifications:

Items Inspection Standards Results
Appearance White Crystals or Crystalline Powder Complies
Identification The infrared Absorption Spectrum Complies
State Of Solution ≥95.0% 98.5%
Specific Rotation [α]20/D -74.0° to -77.0° (C=4 in H2O) -75.2°
pH 5.0~6.5 5.8
Chloride (Cl) ≤0.020% <0.020%
Sulfate (SO4) ≤0.020% <0.020%
Ammonium (NH4) ≤0.020% <0.020%
Heavy Metals (Pb) ≤10ppm <10ppm
Iron (Fe) ≤10ppm <10ppm
Arsenic (As2O3) ≤1ppm <1ppm
Other Amino Acids Conforms Conforms
Loss on Drying <0.20% 0.11%
Residue on Ignition <0.10% 0.08%
H-Hyp-OH Assay 98.5~101.0% 99.4%
Conclusion This Product by Inspection Accords with the AJI92 Standard

51-35-4 - Test Method:

According to AJI92 standard:
Specific rotation: dried sample, C=4, H2O
Transmittance Test: 1.0g in 10mL of H2O, spectrophotometer, 430nm, 10nm cell thickness.
Chloride (Cl): 0.7g, A-1, ref: 0.40ml of 0.01N HCl
Ammonium (NH4): A-1
Sulfate (SO4): 1.2g, (1), ref: 0.50mL of 0.01N H2SO4
Iron (Fe): 1.5g, ref: 1.5mL of Iron Std, (0.01mg/mL)
Heavy metals (Pb): 2.0g, (1), ref: 2.0mL of Pb Std, (0.01mg/mL)
Arsenic (As2O3): 2.0g, (1), ref: 2.0mL of As2O3 Std.
Other amino acids: test sample: 10μg G-1-a
Loss on drying: at 105℃ for 3 hours
Residue on ignition:
Assay Test: dried sample, 130mg, 3mL of formic acid, 50mL of glacial acetic acid, 0.1N HClO4, 1mL=13.113mg L-Hydroxyproline.
PH: 1.0g in 10mL of H2O 

Package & Storage:

Package: Fluorinated Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.

Storage Condition: Store in sealed containers at cool, dry (≤25℃) and ventilated warehouse away from incompatible substances. Protect from light and moisture.

Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock    

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality AssuranceStrict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

SamplesMost products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory AuditFactory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

TransportationBy Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom SynthesisCan provide custom synthesis services to best fit your research needs.

Payment TermsProforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc. 

51-35-4 - Risk and Safety:

Risk Codes
R36/37/38 - Irritating to eyes, respiratory system and skin.
R22 - Harmful if swallowed
Safety Description
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
S27 - Take off immediately all contaminated clothing.
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany 3
RTECS TW3586500
TSCA Yes
HS Code 2922491990
Hazard Class IRRITANT 

Application:

L-Hydroxyproline (H-Hyp-OH) (CAS: 51-35-4), A non-essential amino acid. Can be isolated from gelatin. An optically active form of 4-Hydroxyproline having L-trans-configuration. Unusual amino acids, used in peptide synthesis, pharmaceutical intermediates, biochemical reagents, chemical reagents. L-Hydroxyproline, one of the hydroxyproline (Hyp) isomers, is used as an intermediate for a range of pharmaceutical active ingredients. L-Hydroxyproline is a common non-standard protein amino acid, as the main raw material of antiviral drug Azanavir, it has high application value. L-Hydroxyproline is generally used as a food additive (used as a sweetener), and the use of a relatively large amount as an intermediate for the side chain of Peinan in medicine. Flavor enhancer; nutrition enhancer. Fragrance. Mainly used for fruit juice, cool drinks, nutritious drinks, etc.; Used as a biochemical reagent. Production method proteins such as gelatin, bone glue, casein, soybean epidermis, etc., hydrolyzed with hydrochloric acid, extracted with nitrosation method, refined and crystallized by resin chromatography. 

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