L-Theanine CAS 3081-61-6 Assay 98.0-102.0% (HPLC) Factory
Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of L-Theanine (CAS: 3081-61-6) with high quality.
L-Theanine can be used in the fields of pharmaceutical development and drug discovery research, health care products, food additives and cosmetic raw materials.
Ruifu Chemical can provide worldwide delivery, competitive price, excellent service.
Purchase L-Theanine or other products, please contact us by e-mail: alvin@ruifuchem.com
Chemical Name | L-Theanine |
Synonyms | H-L-Gln(Et)-OH; N-γ-Ethyl-L-Glutamine; N-gamma-Ethyl-L-Glutamine; L-γ-Glutamylethylamide; L-gamma-Glutamylethylamide; L-Glutamic Acid-γ-(Ethylamide) |
Stock Status | In Stock, Commercial Production |
CAS Number | 3081-61-6 |
Molecular Formula | C7H14N2O3 |
Molecular Weight | 174.20 g/mol |
Melting Point | 202.0-215.0℃ |
Density | 1.171±0.06 g/cm3 |
Water Solubility | Soluble in Water, Almost Transparency |
Solubility | Insoluble in Ether and Alcohol |
Storage Temperature | Store Long-Term at 2-8℃ |
COA & MSDS | Available |
Origin of Product | Shanghai, China |
Product Categories |
Amino Acid Derivatives; Food Additives; Pharmaceutical Intermediates |
Shelf Life | 2 Years When Properly Stored |
Specifications | Reference Standard JP2000 |
Brand | Ruifu Chemical |
Items | Specifications | Results |
Appearance | White Crystalline Powder | White Crystalline Powder |
Specific Rotation [α]20/D | +7.7° to +8.5° (C=1, H2O) | +8.0° |
Solubility (1.0g/20ml H2O) | Clear and Colorless | Conforms |
Chloride (Cl) | ≤0.02% | 0.015% |
Iron (Fe) | ≤10ppm | <10ppm |
Heavy Metals (Pb) | ≤10ppm | <10ppm |
Arsenic (As2O3) | ≤2ppm | <2ppm |
Melting Point | 202.0-215.0℃ | Conforms |
Loss on Drying | ≤0.50% | 0.18% |
Residue on Ignition | ≤0.20% | 0.09% |
Assay / Analysis Method | 98.0-102.0% (HPLC) | 99.75% |
pH (1% H2O) | 5.0-6.0 | 5.1 |
Total Plate Count | ≤1000/g | Conforms |
Yeast & Molds | ≤100/g | Conforms |
Salmonella | Absent/10g | Conforms |
Escherichia Coli |
Absent/10g | Conforms |
S.Aureus | Absent/10g | Conforms |
Identification (IR) |
Conforms to Structure | Conforms |
Conclusion | The product has been tested and complies with the given specifications |
Operation Procedures for Test Standard
1 Apparatuses
1.1 Oven
1.2 Resistance stove case
1.3 High efficiency liquid chromatograph
1.4 Rotation apparatus
2. Operation Methods
2.1 Characters
2.1.1 Eyes: White crystalline powder, odorless, a little sweet characteristic taste.
Soluble in water, insoluble in ethanol, ether
2.1.2 Solution Appearance (1.0g/20ml H2O): colourless, transparent.
2.1.3 Melting point: 202-215℃ according to ChP2010 (appendixⅦC)
2.2 Loss on drying
2.2.1 apparatus, equipment
2.2.2.1 weighing bottle with cover on grinding mouth-diameter: 50mm height: 30mm
2.2.2.2 Galvanothermy constant temperature drying case, able to keep temperature 105±2℃.
2.2.2 Analysis steps
Weigh 1g sample with precision to .0002g, put into weighing bottle dried to constant weight in105±2℃ in advance,slightly open the cover, and put into the drying case near level position of thermometer's mercury ball, until constant weight in 105±2℃. Take final test data as test result. The loss weight is not over 0.5% based on ChP2010 (appendixⅨG)
2.2.3 Analysis result description
Water(H2O)(X1),with mass percentage (%) as follows:
m1-m2
X1=——————×100
m
m1 — mass for weighing bottle+sample before drying g;
m2 — mass for weighing bottle+sample after drying g;
m — sample mass g.
2.3 Residual on ignition: according to ChP2010 (appendix ⅨJ), max. 0.1%.
2.4 Chloride: weigh sample 0.5g, add thin nitric acid 10ml. After dissolving, add water to 50ml. Based on ChP2010 (appendix ⅨC), compared with comparison solution made by standard sodium chloride 10.0ml, not over (0.020%).
2.5 pH value: Weigh the sample 1g, put into 100ml volume flask, and add proper distilled water for dissolving and diluting to scale. With clean beaker taking qualified solution around 50ml ,and corrected acidity meter testing directly, pH should be 5.0~6.0 based on ChP2010 (appendix ⅦG)
2.6 Specific Rotation: Take sample 2.5g dissolved by distilled water and diluted to 50ml,and adjust solution temperature to 20℃, put into 1dm rotation tube.Test based on ChP2010 (appendix ⅦE), the specific rotation should be +7.7° - +8.5°.
2.7 Arsenic content: Take sample 1.0g, put into bottle A ,and according to preparation of standard arsenic spot, from "add potassium iodide reagent 5ml”on, operate ChP2010 (appendix ⅨF) (No.1), and make comparison between made arsenic spot and the counterpart made by standard arsenic solution 4.0ml,not more deeper(4ppm)
2.8 Heavy metals: Take sample1.0g, after dissolving with distilled water 20ml, add acetate buffer (pH3.5) 2ml and suitable water to 25ml, test based on ChP2010 (appendix ⅨE) (No 1),the heavy metal cannot be over 10 ppm.
2.9 Assay
2.9.1 Apparatus: high-efficiency liquid chromatograph.
2.9.2 Reagents
2.9.2.1 Acetonitrile (chromatogram grade).
2.9.2.2 Phosphorus acid (analysis grade).
2.9.3 Standard sample
2.9.4 Chromatogram conditions
2.9.4.1 Chromatogram pole: filling L1 (C18 pole),4.6 mm×250mm
2.9.4.2 Flow phase: acetonitrile: 1% phosphorus acid (5:95)
2.9.4.3 Detection wave length: 199nm
2.9.4.4 Flow speed: 1ml/min
2.9.4.5 Sample injection quantity: 20μL.
2.9.5 Standard sample solution
Take L-Theanine standard sample 0.5g, precisely weigh, and dissolved with flow phase and diluted to 50.0ml. Precisely take 2ml, put into 50ml volume flask, and diluted to scale with flow phase。
2.9.6 Intended sample solution
Take sample 0.5g, precisely weigh, and dissolved with flow phase and diluted to 50.0ml. Precisely take 2ml,and put into 50ml volume flask,diluted to scale with flow phase.
2.9.7 Test
Prepare apparatus according to operation procedures of high-efficiency liquid chromatograph, after balance, take standard solution and intended solution for injection, record chromatogram until 1.5 times of the peak reservation time.
2.9.8 Calculation formula
Assay(%)=WsXAiX100%/AsxWi
Ai→ L-theanine peak area of intended sample solution
Ws →standard solution sample weight;
As→L-Theanine peak area of standard solution;
Wi→Intended sample weight;
Package: Fluorinated bottle, Aluminium foil bag, 25kg/cardboard drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed. Store in a cool, dry (2-8℃) and well-ventilated warehouse away from incompatible substances. Keep away from sunshine; avoid fire and heat sources; avoid moisture.
Shipping: Deliver to worldwide by air, by sea, by FedEx / DHL Express. Provide fast and reliable delivery.
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
Hazard Symbols Xi - Irritant
Risk Codes 43 - May cause sensitization by skin contact
Safety Description S28 - After contact with skin, wash immediately with plenty of soap-suds.
S36/37 - Wear suitable protective clothing and gloves.
HS Code 2922491990
1. L-Theanine will reduce blood pressure, blood sugar, blood lipids.
2. L-Theanine powder with the function of removing radicals and anti-aging.
3. L-Theanine powder can enhance the immune function and prevention of colds.
4. L-Theanine powder will anti-radiation,anti-cancer, inhibiting the increasing of cancer cell.
5. L-Theanine powder used to anti-bacterium, with the function of sterilization and deodorization.
L-Theanine (CAS: 3081-61-6) has many potential applications, such as:
Food Additives:
L-Theanine can be used as a quality modifier for beverages, improving the quality and flavor of tea beverages in beverage production. Suitable for dietary formulations in the food and beverage industry. L-Theanine is used as natural antioxidant, antistaling agent, and anti-fading agents.
Cosmetic Raw Materials:
L-Theanine plays a great role in skin care products and has an excellent moisturizing effect. It can be added to moisturizing skin care products to maintain the water content of the skin surface; it also used as an anti-wrinkle agent, which can promote the production of collagen, maintain skin elasticity, and resist wrinkles.
Pharmaceuticals Field:
L-Theanine powder is used to prevent and cure cardiovascular disease, diabetes. L-Theanine is used in the pharmaceutical development and drug discovery research.
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