L-(-)-Threonine CAS 72-19-5 (H-Thr-OH) Assay 99.0~101.0% Factory High Quality
Shanghai Ruifu Chemical Co., Ltd. is the leading supplier of L-(-)-Threonine (H-Thr-OH; Abbreviated Thr or T) (CAS: 72-19-5) with high quality. As one of the largest amino acids suppliers in China, Ruifu Chemical supplys amino acids up to international standards, such as AJI, USP, EP, JP and FCC standards. We can provide COA, worldwide delivery, small and bulk quantities available. If you are interested in L-(-)-Threonine, Please contact: alvin@ruifuchem.com
| Chemical Name | L-(-)-Threonine |
| Synonyms | L-Threonine; H-Thr-OH; L-Thr; Abbreviated Thr or T; Threonine; Laevo-Threonine; (S)-Threonine; (2S,3R)-2-Amino-3-Hydroxybutyric Acid; L-2-Amino-3-Hydroxybutyric Acid; (2S,3R)-(-)-Threonine |
| Stock Status | In Stock, Production Capacity 20000 Tons per Year |
| CAS Number | 72-19-5 |
| Molecular Formula | C4H9NO3 |
| Molecular Weight | 119.12 |
| Melting Point | 256℃(dec.) (lit.) |
| Solubility | Freely Soluble in Formic Acid. Soluble in Water. Practically Insoluble in Ethanol and in Ether. Dissolves in Dilute Hydrochloric Acid |
| Storage Temp. | Sealed in Dry, Store at Room Temperature |
| COA & MSDS | Available |
| Classification | Amino Acids & Derivatives |
| Brand | Ruifu Chemical |
| Hazard Codes | Xi - Irritant |
| Risk Statements | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Statements | S24/25 - Avoid contact with skin and eyes. S37/39 - Wear suitable gloves and eye/face protection S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| TSCA | Yes |
| HS Code | 2922491990 |
| Items | Inspection Standards | Results |
| Appearance | White Crystals or Crystalline Powder; Slightly Sweet Taste | Conforms |
| Identification | Infrared Absorption Spectrum | Conforms |
| Specific Rotation [α]20/D | -27.6° to -29.0°(C=6, H2O) |
-28.4° |
| State of Solution (Transmittance) | Clear and Colorless ≥98.0% | 99.7% |
| Chloride (Cl) | ≤0.020% | <0.020% |
| Sulfate (SO4) | ≤0.020% | <0.020% |
| Ammonium (NH4) | ≤0.020% | <0.020% |
| Iron (Fe) | ≤10ppm | <10ppm |
| Heavy Metals (Pb) | ≤10ppm | <10ppm |
| Arsenic (As2O3) | ≤1.0ppm | <1.0ppm |
| Other Amino Acids | Chromatographically Not Detectable | Conforms |
| Loss on Drying | ≤0.20% | 0.16% |
| Residue on Ignition (Sulfated) | ≤0.10% | 0.04% |
| Assay | 99.0 to 101.0% (Titration: Dried Basis) | 99.7% |
| pH Test | 5.2 to 6.2 (1.0g in 20ml of H2O) | 5.6 |
| Origin | Non-Animal Source | Conforms |
| Residual Solvents | Conforms | Conforms |
| Conclusion | Meets AJI97, USP 41-NF 36, EP 9.0, JP 17 and BP 2016 | |
| Shelf Life | 24 Months From Manufacture Date if Stored Properly | |
| Main Uses | Food / Feed Additives; Pharmaceuticals; Nutritional Supplement; etc. | |
AJI97
L-(-)-Threonine (H-Thr-OH) (CAS: 72-19-5) AJI 97 Test Method
Identification: Compare the infrared absorption spectrum of the sample with that of the standard by potassium bromide disc method.
Specific Rotation [α]20/D: Dried Sample, C=6, H2O
State of Solution (Transmittance): 1.0g in 10ml of H2O, spectrophotometer, 430nm, 10mm cell thickness.
Chloride (Cl): 0.7g, A-1, ref: 0.40ml of 0.01mol/L HCl
Ammonium (NH4): B-1
Sulfate (SO4): 1.2g, (1), ref: 0.50ml of 0.005mol/L H2SO4
Iron (Fe): 1.5g, ref: 1.5ml of Iron Std. (0.01mg/ml)
Heavy Metals (Pb): 2.0g, (1), ref: 2.0ml of Pb Std. (0.01mg/ml)
Arsenic (As2O3): 2.0g, (1), ref: 2.0ml of As2O3 Std.
Other Amino Acids: Test Sample: 50μg, B-6-a, control: L-Thr 0.25μg
Loss on Drying: at 105℃ for 3 hours.
Residue on Ignition (Sulfated): AJI Test 13
Assay: Dried sample, 120mg, (1), 3ml of formic acid, 50ml of glacial acetic acid, 0.1mol/L HCLO4 1ml=11.912mg C4H9NO3
pH Test: 1.0g in 20ml of H2O
USP35-NF30
DEFINITION
Threonine contains NLT 98.5% and NMT 101.5% of L-threonine (C4H9NO3), calculated on the dried basis.
IDENTIFICATION
A. INFRARED ABSORPTION <197K>
ASSAY
PROCEDURE
Sample: 110 mg of Threonine
Blank: Mix 3 mL of formic acid and 50 mL of glacial acetic acid.
Titrimetric system
(See Titrimetry <541>)
Mode: Direct titration
Titrant: 0.1 N perchloric acid VS
Endpoint detection: Potentiometric
Analysis: Dissolve the Sample in 3 mL of formic acid and 50mL of glacial acetic acid. Titrate with the Titrant. Perform the Blank determination.
Calculate the percentage of Threonine (C4H9NO3) in the Sample taken:
Result = {[(VS-VB) xNxF]/W} x100
VS= Titrant volume consumed by the Sample (mL)
VB= Titrant volume consumed by the Blank (mL)
N= actual normality of the Titrant (mEq/mL)
F= equivalency factor, 105.1mg/mEq
W= Sample weight (mg)
Acceptance criteria: 98.5%~101.5% on the dried basis
IMPURITIES
RESIDUEON IGNITION <281>: NMT 0.1%
CHLORIDE AND SULFATE, Chloride <221>
Standard solution: 0.50mL of 0.020 N hydrochloric acid
Sample: 0.73g of Threonine
Acceptance criteria: NMT 0.05%
CHLORIDE AND SULFATE, Sulfate <221>
Standard solution: 0.10mL of 0.020 N sulfuric acid
Sample: 0.33g of Threonine
Acceptance criteria: NMT 0.03%
IRON <241>: NMT 30ppm
Delete the following:
HEAVY METALS, Method I <231>: NMT 15ppm
RELATED COMPOUNDS
Diluent: Hydrochloric acid and water (1:99)
System suitability solution: 0.4mg/mL each of USP L-Threonine RS and USP L-Proline RS in Diluent
Standard solution: 0.05mg/mL of USP L-Threonine RS in Diluent. [NOTE-This solution has a concentration equivalent to about 0.5% of that of the Sample solution.]
Sample solution: 10mg/mL of Threonine in 2 N hydrochloric acid
Chromatographic system (See Chromatography <621>, Thin-Layer Chromatography.)
Mode: TLC
Adsorbent: 0.25-mm layer of chromatographic silica gel mixture
Application volume: 5μL
Developing solvent system: Butyl alcohol, glacial acetic acid, and water (3:1:1)
Spray reagent: 2 mg/mL of ninhydrin in a mixture of butyl alcohol and 2N acetic acid (95:5)
System suitability
Suitability requirements: The chromatogram of the System suitability solution exhibits two clearly separated spots.
Analysis
Samples: System suitability solution, Standard solution, and Sample solution.
After air-drying the plate, spray with Spray reagent, and heat between 100° and 105° for 15 min. Examine the plate under white light.
Acceptance criteria: Any secondary spot of the Sample solution is not larger or more intense than the principal spot of the Standard solution.
Individual impurities: NMT 0.5%
Total impurities: NMT 2.0%
SPECIFIC TESTS
OPTICAL ROTATION, Specific Rotation <781S>
Sample solution: 60 mg/mL in water
Acceptance criteria: -26.7° to -29.1°
PH <791>
Sample solution: 50 mg/mL solution
Acceptance criteria: 5.0~6.5
LOSSON DRYING <731>: Dry a sample at 105℃ for 3 h: it loses NMT 0.2% of its weight.
ADDITIONAL REQUIREMENTS
PACKAGING AND STORAGE: Preserve in well-closed containers.
USP REFERENCE STANDARDS <11>
USP L-Proline RS
USP L-Threonine RS
Package: Fluorinated Bottle, 25kg/bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool, dry and ventilated warehouse away from incompatible substances. Protect from light and moisture.
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
L-(-)-Threonine (H-Thr-OH; Abbreviated Thr or T) (CAS: 72-19-5) is used for biochemical research, as amino acid nutrition medicine on medicine, mainly used in the treatment of anemia. Amino acid drugs. Nutritional Supplement.
L-Threonine can be used in the food industry in nutrition supplements, added to food, L-Threonine can improve the nutritional value of protein, so that adequate food nutrients more reasonable. L-Threonine and glucose were hot, fragrant and easy to produce coke chocolate flavor in a flavor enhancer in food processing role.
L-Threonine in the feed industry, L-Threonine amino acids can be used as feed additives for the feed supply of protein has opened up new avenues, L-Threonine not only improves the nutritional value of feed, reduce feeding costs. But also get to promote animal growth and development, enhance disease resistance and so many other beneficial effects.
L-Threonine is necessary for animals to maintain growth, the animals can not be synthesized. Must be from the food supply. L-Threonine lack can lead to reduced animal intake. Stunted, feed efficiency decreased immune function suppression symptoms. L-Threonine is the second methionine, lysine, tryptophan, essential amino acids after the fourth livestock feed additive, L-Threonine of livestock growth and development, strengthen the fattening, lactation, egg production were significantly facilitating role.
Threonine is an important kind of analeptic which fortifies cereal,pastry and dairy products.Like tryptophan,it rejuvenates human bodies and promotes the growth of infants.When applied in pharmaceutical field,threonine can moisten human skins due to the hydroxy in its structure.Combined with oligose,it protects human cell membranes,and accelerates the synthesis of phosphatide and the oxidation of fatty acid.With a medicinal effect of preventing fatty liver,threonine preparation works as a component of compound amino acid injection,Meanwhile,threonine can be used for the production of monobactams,one of high-effect and low-allergy antibiotics.
As amino acid for forge,threonine is widely added in the forage for newborn pig,covering pig,poultry,shrimp,eel and so.It can:
-Keep the balance of amino acids in the forage and stimulate the growth of the animals;
-Improve the meat quality;
-Increase the nutritive value of forage raw materials which have low amino acid digestibility;
-Apply to the production low-protein forage;
-Cut down the cost of raw materials for forage;
-Decrease the nitrogen content in the excrement and urine of animals so that the release of ammonia is slowed and the ammonia concentration is kept low in animal shed.
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