Afatinib Dimaleate CAS 850140-73-7 Puritas >99.5% (HPLC) API Featured Image

Afatinib Dimaleate CAS 850140-73-7 Munditia >99.5% (HPLC) API

Description:

Chemical Name: Afatinib Dimaleate

Synonyma: BIBW2992 Dimaleate

CAS: 850140-73-7

Puritas: >99.0% (HPLC)

Aspectus: Alba ad Off-White pulveris

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E-Mail: alvin@ruifuchem.com

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Product Detail

Product Tags

Descriptio:

Ruifu Chemical Supple intermedia de Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
acetaldehyda Diethyl acetalis CAS 3616-56-6
trans-4-dimethylaminocrotonic Acidum hydrochloridum CAS 848133-35-75
Diethylphosphonoaceticum acidum CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-one CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl) -7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineCAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineCAS 314771-88-5

Chemical Properties:

Nomen chemicum	Afatinib Dimaleate
Synonyma	BIBW2992 Dimaleate;(S, E)-N-(4-(3-Chloro-4-Fluorophenylamino)-7-(Tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(dimethylamino)but-2-Enamide dimaleate
CAS Number	618-89-3
CATTUS Number	RF-PI2032
Stock Status	In Stock, Productio Ascendite ad Tons
Formulae hypotheticae	C32H33ClFN5O11
M. Pondus	718.08
Sensibilitas	umorem Sensitivum
Brand	Ruifu Chemical

Specifications:

Item	Specifications
Aspectus	Alba ad Off-White pulveris
Puritas / Analysis Methodus	>99.5% (HPLC)
Damnum in Siccatio	<0.50%
Residere in Ignition	<0.10%
Maximum Impuritas	<0.30%
Totalis immunditias	<0.50%
Metalla gravia (ut Pb)	≤20ppm
Infrared Imaginis	Conformat ut Structure
NMR	Conformat ut Structure
Test Standard	Enterprise Standard
Fasciae vita	XXIV menses si proprie Repono
Consuetudinem	API

Sarcina & Repono:

sarcina: Utrem, aluminium foil, sacculum, 25kg/cardboard Drum, vel secundum exigentiam emptoris

Repono Condition:Repone in vasis signatis in loco frigido et sicco;Protege a lumine et humore

commoda:

FAQ:

Applicatio:

Afatinib Dimaleate (CAS: 850140-73-7), forma salis dimaleatis afanitib, ore promptum est agens antineoplasticum.Afatinib Dimaleate irreversibilis est EGFR inhibitor familiae cum IC50s 0,5 nM, 0,4 nM, 10 nM et 14 nM pro EGFRwt, EGFRL858R, EGFRL858R/T790M et HER2, respective.Afatinib Dimaleate indicatur curationis primae aegris cum metastatica non-parva cellula pulmonis cancri (NSCLC) cuius tumores receptaculum incrementum epidermalium habent (EGFR) exon 19 deletionum vel exon 21 (L858R) substitutionis mutationum per FDA- detectae. probatus test.Praeteritis, curatio vexillum cum chemotherapy duplicata ratione platini-substructio mensurae primae lineae curationis pro omnibus aegris cum NSCLC habendus est.Sed argumenta emergentes subpopulationes identificantur in quibus iaculis justo efficacior est, ducens ad progressionem medicamentorum specialium mutationum.Afatinib Dimaleate a Boehringer Ingelheim pharmaceutica evoluta est, Afatinib Dimaleate a FDA anno 2013 probata est ut medicamentum orphanum sub Gilotrif nomine commercii.Afatinib Dimaleate chemica modos regulas utens summatim perstringitur.Afatinib Dimaleatenon solum activa contra mutationes EGFR iaculis a generatione prima TKIs sicut erlotinib vel gefitinib, sed etiam contra mutationes ut T790M quae non sentientes ad has therapias normas.Propter additam actionem contra Her2, investigatur pro carcinomate pectoris necnon aliis EGFR et Her2 carcinomata agitata.