Afatinib Dimaleate Intermedia CAS 314771-76-1 Puritas >99.0% (HPLC) Factory

Description:

Chemical Name: (S)-N4-(3-Chloro-4-Fluorophenyl) -7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-Diamine

CAS: 314771-76-1

Puritas: >99.0% (HPLC)

Aspectus: lux Yellow ad Yellow pulverem

Afatinib Dimaleate (CAS: 850140-73-7)

E-Mail: alvin@ruifuchem.com

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Product Detail

Product Tags

Descriptio:

Ruifu Chemical Supple intermedia de Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
acetaldehyda Diethyl acetalis CAS 3616-56-6
trans-4-dimethylaminocrotonic Acidum hydrochloridum CAS 848133-35-75
Diethylphosphonoaceticum acidum CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-one CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl) -7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineCAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineCAS 314771-88-5

Chemical Properties:

Nomen chemicum	(S)-N4-(3-Chloro-4-Fluorophenyl) -7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-Diamine
Synonyma	N4-(3-Chloro-4-Fluorophenyl) -7-[[(3S)-Tetrahydro-3-Furanyl]oxy] -4,6-Quinazolinediamine;Afatinib immunditia B;Afatinib-des(4-Dimethylamino-2-en-1-oxo)butyl;Des(4-Dimethylamino-2-en-1-oxo)butyl Afatinib
CAS Number	314771-76-1
CATTUS Number	RF-PI2028
Stock Status	In Stock, Productio Capacitas 100MT/Annus
Formulae hypotheticae	C18H16ClFN4O2
M. Pondus	374.8
Ferveret	559.0±50.0℃
Density	1.473±0.060 g/cm3
Brand	Ruifu Chemical

Specifications:

Item	Specifications
Aspectus	Lux Yellow ad Yellow pulverem
Lepidium sativum	In retentione Time of principalis Pecco in HPLC debet respondere ad vexillum
Puritas / Analysis Methodus	>99.0% (HPLC)
Damnum in Siccatio	<0.50%
Residere in Ignition	<0.20%
una immunditia	<0.50%
Totalis immunditias	<1.00%
Metalla gravia (ut Pb)	≤20ppm
Test Standard	Enterprise Standard
Consuetudinem	Afatinib Dimaleate (CAS: 850140-73-7)

Sarcina & Repono:

sarcina: Utrem, aluminium foil, sacculum, 25kg/cardboard Drum, vel secundum exigentiam emptoris

Repono Condition:Repone in vasis signatis in loco frigido et sicco;Protege a lumine et humore

commoda:

FAQ:

Applicatio:

(S)-N4-(3-Chloro-4-Fluorophenyl) -7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-Diamine (CAS: 314771-76-1) medium est ex Afatinib Dimaleate (CAS: 850140-73-7).Afatinib est secundae-generatio potentis et immedicabilis dualis inhibitoris incrementi epidermalis factoris receptoris (EGFR) et factoris incrementi humani epidermalis receptoris 2 (HER2) kinasis tyrosinae, a Boehringer Ingelheim, Germania evoluta.Capax est irreversibiliter inhibere activitates tyrosinae kinasi Michaelem reactionem cum thiol coetus cysteini in positione 797 EGFR subeundo.Munus: 1. Sicut Lapatinib et Neratinib, Afatinib est interdum inhibitor kinasus qui etiam irrevocabiliter impedit factorem 2 (Her2) et factor incrementi epidermalis receptoris (EGFR) kinases.2. Afatinib non solum activum contra mutationes EGFR iaculis a generatione prima TKIs sicut erlotinib vel gefitinib, sed etiam contra mutationes ut T790M quae ad has therapias normas non sentiuntur.Propter additam actionem contra Her2, investigatur pro carcinomate pectoris necnon aliis EGFR et Her2 carcinomata agitata.3. Afatinib medicamentum est curationi primae lineae aegris cum distinctis generibus metastaticorum (EGFR mutationem positivam) non parvam cellula pulmonis carcinoma (NSCLC).Agit inhibitor irreversibilis covalentis receptae tyrosinae kinases epidermalis aucti factoris receptoris (EGFR) et erbB-2 (HER2).