Risperidone CAS 106266-06-2 Intende 98.0~ 102.0%
Shanghai Ruifu Chemical Co, Ltd. est primarium fabricam Risperidone (CAS: 106266-06-2) cum qualitate alta.Ruifu Chemical traditio totius terrarum, quantitatis competitive pretium, optimum servitium, parvas et moles in promptu habere potest.Emptio Risperidone,Please contact: alvin@ruifuchem.com
| Nomen chemicum | Risperidone |
| Synonyma | 3-[2-[4-(6-Fluoro-1,2-Benzisoxazol-3-yl)-1-Piperidinyl]ethyl]-6,7,8,9-Tetrahydro-2-Methyl-4H-Pyrido[1 ,2-a]pyrimidin-4-one;Risperdal;Risperidal;Risperdal Consta;Rispolept;Risperin;Rispolin;Sequinan;Risperdal M-Tab |
| Stock Status | In Stock, Commercial Productio |
| CAS Number | 106266-06-2 |
| Formulae hypotheticae | C23H27FN4O2 |
| M. Pondus | 410.49 g/mol |
| Liquescens punctum | 170.0 ad 174.0℃ |
| Density | 1.38±0.10 g/cm3 |
| Periculum Classis | 6.1;Venenum |
| COA & MSDS | Praesto |
| Origin | Shanghai, China |
| Brand | Ruifu Chemical |
| Items | Specifications | Proventus |
| Aspectus | Alba ad Off-White pulveris | Obsequitur |
| Lepidium sativum | Infrared effusio | Obsequitur |
| Lepidium sativum B * | Retention tempus: respondet Reference substantia | Obsequitur |
| Damnum in Siccatio | <0.50% | 0.12% |
| Residere in Ignition | <0.10% | 0.07% |
| Metalla gravis | <0.001% | <0.001% |
| Related Compounds | ||
| E-Oxime | <0.20% | <0.20% |
| Z-Oxime | <0.20% | <0.20% |
| 9-Hydroxyrisperidone | <0.20% | <0.20% |
| 5-Fluororisperidone | <0.20% | <0.20% |
| 6-Methylrisperidone | <0.20% | <0.20% |
| Ignota immunditia | <0.10% | <0.10% |
| Totalis immunditias | <0.30% | <0.30% |
| Assay | 98.0~ 102.0% (Calculatae in Basis aridae) | 100.52% |
| conclusio | Productum probatum est et obtemperat cum USP 35 Standard | |
Sarcina:Utrem, aluminium foil, sacculum, 25kg/cardboard Drum, vel secundum exigentiam emptoris.
Repono Condition:Continentem arcte clausam et in loco frigido, sicco (2~8℃) reponunt et a cellis bene ventilatis ab substantiis incompossibilibus.A luce et humore protege.
Naviportans:Libera ad mundum ab aere, per FedEx / DHL Express.Ieiunium et certas traditiones provide.
Risperidone
C23H27FN4O2 410.48
4H-pyrido[1,2-a]pyrimidin-4-unus 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7 ,8,9-tetrahydro-2-methyl-.
3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidino]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2- a]pyrimidin-4-one [106266-06-2].
» Risperidone non minus quam 98.0 centesimas continet et non plus quam 102.0 centesimas C23H27FN4O2, fundamento siccato computatum.
Packaging and storage- Conserve in vasis bene clausis.Repono in locus temperatus.
USP Reference signa <11>-
USP Risperidone RS
3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2- a]pyrimidin-4-one 410.48 CAS-106266-06-2
USP Risperidone System Suitability Mixture RS
Continet risperidones et fere 0,2% cuiusque sequentis:
Z-Oxime-3-[2-[4-[(Z)-(2,4-difluorophenyl)(hydroxyimino)methyl]piperidin-1-yl]ethyl]-2-methyl-6,7,8,9- tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one.
9-Hydroxyrisperidone-(6RS)-3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2,6-dimethyl-6,7; 8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one.
6-Methylrisperidone-(6RS)-3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2,6-dimethyl-6,7; 8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one.
Haec mixtura risperidone, Z-oxime, 9-hydroxyrisperidone, et 6-methylrisperidone continet.]
Identification-
A: Absorptio infrared <197K>.
B: Retentionis tempus maioris culminis in praeparatione chromatogrammi Assay respondet illi in praeparatione chromatogram Standardi, prout habetur in Assay.
Damnum in siccitate <731>- Sicca in vacuo ad 80 pro 4 horis: non plus quam 0.5% sui ponderis amittit.
Residere ignitionem <281>: non plus quam 0.1%, speciminis experimenti 2.0-g adhibito.
Metalla gravia, Methodus II <231>: 0.001%.
Related compounds-
Solutio quiddam, Solutio A, Solutio B, Mobilis Phase, Diluens, Ratio idoneitatis Solutio, et Systema chromatographicum-Para ut in Intagine ordinatur.
Vexillifer solutionis-Usus ad Vexilliferum praeparationem, paratus ut ordinatus in Assay.
Expertus solutione utere Praeparatione Ingredi.
De modo procedendi-Inject volumina paria (circiter 10 µL) solutionis Standardi ac solutionis testium in chromatographum et chromatogrammum referunt.Ignosce immunditias utentes retentione relativa tempora in Tabula 1 datas, et metire apicem responsionum.Recipis cujusque risperidones compositi in portione Risperidone sumpta formulae calculare recipis:
100(CS/CU)(rU/rS)(1/F)
in quibus CS et CU sunt concentrationes, in mg per mL, de risperidone in solutione Standard et solutione test respective;rU area cujusvis immunditiae ex teftium solutione obtinet apicem ;rS apicem area risperidone ex solutione apocrypha obtinet;and F is the relative response factor pro cuiusque immunditiae respectu risperidone.Praeter limites in Tabula 1 non excedentes, non plus quam 0.10% cuiuslibet impuritatis ignotae (usus F valoris 1.0) invenitur et non plus quam 0.30% totius immunditiae invenitur.Montium immunditiam contemne minus quam 0.05%.
Table 1
Related Compone Retentionis Tempus (RRT) Response Relativum Factor (F) Limit (%)
E-oxime1 0.60 1.0 NMT 0.20
Z-oxime2 0.67 0.63 NMT 0.20
9-hydroxyrisperidone3 0.76 0.92 NMT 0.20
5-fluororisperidone4 0.94 1.0 NMT 0.20
Risperidone 1.0 1.0 -
6-methylrisperidone5 1.2 0.95 NMT 0.20
1 3-[2-[4-[(E)-(2,4-Difluorophenyl)(hydroxyimino)methyl]piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydro-4H -pyrido[1,2-a]pyrimidin-4-one
2 3-[2-[4-[(Z)-(2,4-Difluorophenyl)(hydroxyimino)methyl]piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydro-4H -pyrido[1,2-a]pyrimidin-4-one
3 (9RS) -3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-9-hydroxy-2-methyl-6,7,8 ,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
4 3-[2-[4-(5-Fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydro-4H-pyrido [1,2-a] pyrimidin-4-one
5 (6RS) -3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2,6-dimethyl-6,7,8,9 -tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
Assay-
Quiddam solution- Dissolve ammonium acetatis 15.4 g aquae in 1 L.Acidum aceticum cum 10% pH ad 6.5 compone, et misce.
Solutio A-Mix 100 mL solutionis Bufferae cum 150 mL methanoli in lagena voluminis 1000-mL, et aqua diluta ad volumen.
Solutio B- Misce 100 mL solutionis Bufferae cum 850 mL methanoli in ampulla voluminis 1000-mL, et aqua ad volumen diluta.
Mobile phase-Usus mixtura variabilis Solutio A et Solutio B ut ad systema chromatographicum ordinatur.Fac si opus sit adaptationes (cf. Systema Suitability sub Chromatographia 621).
Diluent-Mix 100 mL Buffer solutionis cum 900 mL aquae et 1000 mL methanoli.
Systema solutionis idoneitatis-Para 1 mg per mL solutionem USP Risperidone Systema convenientia Mixturae RS in Diluent.
Praeparatio-Latina accurate ponderata quantitatem USP Risperidone RS in Diluent, et quantitatis dilue, et gradatim si opus est, cum Diluent solutionem obtinendam habens intentionem notam circa 1.0 mg per mL.
Praeparatio-dissolve quantitatem Risperidonis in Diluent accurate perpensis, et quantitatis dilue, et gradatim, si opus est, cum diluente ad solutionem obtinendam collationem circiter 1.0 mg per mL habentem.
Systema chromatographicum (cf. chromatographia <621>) - chromatographum liquidum cum detectore 275-um et 4.6-mm × 10-cm instructum est columna quae continet 3-µm fasciculum L1.Rate fluxus circiter 1.5 mL per minute est.Columella temperatura conservatur 35. Chromatographum hoc modo programmata est.
Solutio tempus (minuta) Solutio A (%) Solutio B (%) Elution
0-1 70 30 isocratic
1-20 70®5 30®95 clivus linearis
20-25 5 95 isocratic
25-27 5®70 95®30 clivus linearis
27-35 70 30 re-equilbrationInject solutionis convenientiae System.Apicem responsiones pro modo procedendi notare, et apices dignoscere Z-oxime, 9-hydroxyrisperidone, 6-methylrisperidone, et risperidone retentionis temporibus relativis utens ex Tabula 1;resolutio, R, inter Z-oximam et 9-hydroxyrisperidone minus quam 2.8;tendiculationis factor pro risperidone non plus quam 1.5;et vexillum relativum declinationis ad injectiones replicatae non plus quam 2.0% ad apicem risperidonis.
De modo procedendi- Separatim injiciunt volumina paria (circa 10 µL) praeparationis vexilliferae et praeparatio in chromatographa, et responsiones pro risperidone apicem metire.Quantitatem in centesimis C23H27FN4O2 computa, in portione Risperidone formula sumpta:
100(CS/CU)(rU/rS)
in quibus CS et CU sunt concentrationes, in mg per mL, de risperidone in praeparatione Vexilliferorum et de praeparatione primordium, respective;and rU and rS are the apicem responses obtained from the Assy preparation and the Latin preparation, respectively.
Quam mercari?Quaeso contactumDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Annorum Usus?Plus quam XV annos experientiae habemus in fabricando et exportando amplis intermediis pharmaceuticis vel alchimicis pharmaceuticis amplis.
Mercatus principalis?Vendere mercatum domesticum, Americam septentrionalem, Europam, Indiam, Coream, Iaponicam, Australiam etc.
Commodi?Superior qualitas, parabilis pretium, officia professionalia et subsidia technica, ieiunium partus.
Qualitasfides?Qualitas strictioris temperantiae ratio.Pro instrumento analysi professionali includuntur NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Claritas, Solubilitas, Microbialis limes test, etc.
Exempla?Pleraque producta praebent exempla gratuita pro qualitate aestimationis, sumptus naviculas a clientibus solvendos.
Factory Audit?Factory audit gratissimum.Quaeso ante constitutum.
MOQ?Nec MOQ.Parvus ordo placet.
Tempus adferendi? Si intus prosapia, tres dies partus praestatur.
Transportatio?Per Express (FedEx, DHL), ab Air, per Mare.
Documenta?Post servitium venditionis: COA, MOA, ROS, MSDS, etc. praeberi possunt.
Consuetudo Synthesis?Consuetudo synthesis officia praebere potest ad optimas investigationes tuas necessitates aptandas.
Pensio conditio?Proforma cautionis primum post confirmationem ordinis mittetur, informationes nostrae ripae inclusas.Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
Periculum Codes R25 - Toxicus absorptus
R23/24/25 - Toxicus ab inspiratione, in contactu cum cute et absorptus.
R11 - Flammabiles
Salutis descriptio S28 - Post contactum cum cute, statim lavabit copia saponis suds.
S36 - gere idoneos tutelae vestis.
S45 - In casu casu vel si bene sentis, consilium medicinae statim quaere (titalam quoties fieri potest).
S36/37 - indumentis tutelae idoneis gere et caestus.
S16 - Ex ignitionis fontibus abstinete.
UN IDs 3249
WGK Germania 3
RTECS UV1164800
HS Codicis 2934999099
Aleam Class 6.1 (a)
Stipare Group II
Risperidone (CAS: 106266-06-2) repugnantia effectum habet in receptoribus 5HT2 et D2 receptoribus.Risperidone ad schizophreniam acutam et veterem.Medicamenta antipsychotica.Risperidone adhibentur ad curationem acuti et chronici schizophreniae et alia varia status psychotici manifesta indicia affirmativa (sicut hallucinationes, illusiones, perturbationes cogitationis, inimicitiae, suspiciones) et indicia negativa significantes (ut inconstantiam, motus acediam et accidiam socialem, paucorum. verba).Etiam sublevare potest symptomata affectiva cum schizophrenia coniuncta (ut: tristitia, culpa, anxietas).Aegris quos Risperidone efficax est ad acutam curationem, in tempore curationis conservando, Risperidone efficaciam suam clinicam ludere pergere potest.Risperidone igitur actio therapeutica in symptomata tam positiva et negativa schizophreniae habet et signanter pauciores effectus producit praesertim symptomata extrapyramidalia cum puris D2 contra antipsychoticis communiter adhibitis.Etiam in potentia ad administrationem alcohol detractionis et PROCLIVITAS cocaini habet.
