TMC207 CAS 843663-66-1 Puritas >99.5% (HPLC)
| Nomen chemicum | TMC207 |
| Synonyma | TMC-207, R207910;Sirturo;(αS, βR) -6-Bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl-β-phenyl-3-Quinolineethanol;1-(6-bromo-2-methoxyquinolin-3-yl) -4-dimethylamino-1-phenyl-2-(1-naphthyl) 2-butanolum |
| CAS Number | 843663-66-1 |
| CATTUS Number | RF2336 |
| Stock Status | In Stock, Productio Ascendite ad Tons |
| Formulae hypotheticae | C32H31BrN2O2 |
| M. Pondus | 555.516 |
| Liquescens punctum | 104℃ |
| Density | 1.322±0.06 g/cm3 |
| Sensitiva | Hygroscopic.Lux Sensitiva, Aeris Sensitiva |
| Brand | Ruifu Chemical |
| Item | Specifications |
| Aspectus | Alba vel Off-White pulveris |
| Puritas / Analysis Methodus | >99.5% (HPLC) |
| Damnum in Siccatio | <0.50% |
| Residere in Ignition | <0.20% |
| Omnis immunditia | <0.10% |
| Isomer | <0.10% |
| Totalis immunditias | <0.50% |
| Metalla gravia (ut Pb) | <20ppm |
| Arsenicum (As) | <2.0ppm |
| Infrared Imaginis | Conformat ut Structure |
| Proton NMR Spectrum | Conformat ut Structure |
| Test Standard | Enterprise Standard |
| Consuetudinem | API |
sarcina: Utrem, aluminium foil, sacculum, 25kg/cardboard Drum, vel secundum exigentiam emptoris
Repono Condition:Repone in vasis signatis in loco frigido et sicco;Protege a lumine et humore
Quam mercari?Please contact: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience?Plus quam XV annos experientiae habemus in fabricando et exportando amplis intermediis pharmaceuticis vel alchimicis pharmaceuticis amplis.
Mercatus principalis?Maxime exportantur in Americam Septentrionalem, Indiam, Russiam, Coream, Iaponicam, et Europam, etc.
Qualitasfides?Certa qualitas certitudinis, stricte procuratio.Pro instrumento analysi professionali includuntur NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Claritas, Solubilitas, Microbialis limes test, etc.
Exempla?Pleraque producta praebent exempla gratuita pro qualitate aestimationis, sumptus naviculas a clientibus solvendos.
Factory Audit?Factory audit gratissimum.Quaeso ante constitutum.
MOQ?Nec MOQ.Parvus ordo placet.
Tempus adferendi? Si intus prosapia, tres dies partus praestatur.
Transportatio?Per Express (FedEx, DHL), per Air, per mare.
Consuetudo Synthesis?Consuetudo potest providere officia synthesin.
Pensio conditio?Proforma cautionis primum post confirmationem ordinis mittetur, informationes nostrae ripae inclusas.Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
(CAS: 843663-66-1), (ut TMC207 et R207910), nomen artis Sirturo tradens, novum diarylquinolinum antimycobacteriale medicamentum, quod tuberculosi afficit, inhibendo activitates M. tuberculosis ATP synthaseos protonis sentinae.ATP synthesis mycobacteriae exercet effectus antibacteriales et bactericidales.Amet in adulta multidrug-repugnans tuberculosis tractabat (MDR-PTB).TMC207 eandem actionem bactericidal contra M. tuberculosis modos sensitivos et modos renitentes habet, et etiam bonum sterilizationis effectum bacteria sopitam habet.Mense Decembri MMXII, US FDA TMC207 approbavit ut pars compositionis therapiae ad tractationem multi-medici tuberculosis resistentis (MDRTB).TMC207 primum medicamentum pro MDR-TB probatum est et prima probatio est ex novo genere agentium antituberculosis in praeterito 40 anno.Ob summam necessitatem inmetmedicam tractandi MDR-TB, FDA approbatio accelerata concessa TMC207 in Phase II consequitur, aegris medicamentis accessum praebens dum studia clinica additamenta exercentur.TMC207 est diarylquinolinum, quod ex alto throughput, totius-cellulae protegendo militarium cum Mycobacterio smegmatis in vicaria M. tuberculosi adhibitum inventum est.TMC207 unus enantiomer initialis protegendi ictus est.TMC207 contra mycobacteria potentem et selectivam actionem habet, et contra M. tuberculosim tam pharmacopolam-sensitivum quam pharmacopolam resistentem agit.Mechanismus actionis TMC207 unica est inter medicamenta anti-TB ac inhibitionem mycobacterial ATP synthasi;ATP synthase non est contra hominem activum.TMC207 in viva actione in multis preclinicis exemplaribus TB infectionis, sola et in compositione cum aliis agentibus anti-TB, habet ac bactericidalem actionem in TB infectionis exemplaribus constitutam habet.TMC207 quinque gradibus componitur ab 3-Acidi Phenylpropionici et para-Bromoanilini.Sequentes inter formationem, curatio cum POCl3 et DMF sub conditiones Vilsmeier-Hack productum 2-chloroquinolinum dederunt.Curatio cum methoxide sodium, quam sequitur condensatio cum 3-(Dimethylamino)-1-(naphthalen-1-yl)propan-1-unum, et separatio isomorum dedit TMC207.
