Imatinib Mesylate CAS 220127-57-1 Assay 98.0%~ 102.0% Ph+CML API Factory Quality
Commercial Supple Imatinib Mesylate et intermedia:
Imatinib Mesylate CAS: 220127-57-1
N-(2-Methyl-5-nitrophenyl) -4-(pyridin-3-yl) pyrimidin-2-amine CAS: 152460-09-8
N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea CAS:
4-[(4-Methylpiperazin-1-yl) methyl] acidum benzoicum dihydrochloridum CAS: 106261-49-8
Nomen chemicum | Imatinib Mesylate (forma alpha) |
Synonyma | Imatinib Methanesulfonate;STI571 Mesylate;CGP-57148B |
CAS Number | 220127-57-1 |
CATTUS Number | RF-API19 |
Stock Status | In Stock, Productio Ascendite ad Tons |
Formulae hypotheticae | C30H35N7O4S |
M. Pondus | 589.71 |
Shipping Condition | Sub Ambient Temperature |
Brand | Ruifu Chemical |
Item | Specifications |
Aspectus | Alba ad Off-White Crystalline pulveris |
Solubilitas | Facile dissolvere aquam |
HPLC Lepidium sativum | Sample spectrum principale apicem retentionis temporis secundum quod |
IR Lepidium sativum | Infrared effusio spectrum specimen secundum quod specimen |
Liquescens punctum | 214.0~222.0℃ |
Damnum in Siccatio | ≤0.50% |
Residere in Ignition | ≤0.10% |
Metalla gravis | ≤20ppm |
Substantiae cognatae | (1) Impuritas G: NMT 0.3% |
(2) Impuritas B: NMT 0.3% | |
(3) Impuritas C: NMT 0.3% | |
(4) Impuritas D: NMT 0.3% | |
(5) Impuritas A: NMT 0.3% | |
(6) Impuritas H: NMT 0.3% | |
(7) Impuritas F: NMT 0.3% | |
(8) Impuritas E: NMT 0.3% | |
(9) Maxima impudicitia: NMT0.1% | |
RELICTUM Solvents | (1) Ethyl Acetate: NMT 5000ppm |
(2) Methanol: NMT3000ppm | |
(3) Dichloromethane: NMT 600ppm | |
(4) Ethanol: NMT 5000ppm | |
(5) Toluene: NMT 890ppm | |
(6) Dimethyl Sulfoxide: NMT5000ppm | |
HPLC Assay | 98.0%~ 102.0% (C30H35N7SO4 Calculatum super Basis Anhydrous) |
Test Standard | Enterprise Standard |
Consuetudinem | API;Ph+CML |
sarcina: Utrem, aluminium foil, pera, cardboard tympanum, 25kg/Drum, vel secundum exigentiam emptoris.
Repono Condition:Repone in vasis signatis in loco frigido et sicco;Protege a lumine, humore et pestis infestatione.
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Imatinib Mesylate (CAS 220127-57-1) est molecula parva quae kinasum tyrosinum interdum-Abl vetat, kinasum speciei momenti ad multiplicationem myelogenae leukemia longae (CML).Maxime specifica pro BCR-ABL, enzyme cum myelogeno leukemia chronico (CML) et quibusdam formis lymphoblasticis leukemia acutis (ALL).Inhibitor inhibitor potens et selectivus v-Abl tyrosinus est (IC50 = 38 nM).Eventus translocatio inter chromosomata 9 et 22 chromosomatum Philadelphiae gignit, quod inde fusionem interdum Bcr-Abl producit cum actione kinasi aberrantis quae celerem cellulam multiplicationem promovet.Imatinib mesylate ligat hanc kinasem crucialem, claudicans CML incrementum affinis.Imatinib mesylate inhibere PDGFR et kinases tyrosinas cum c-Kit, ulterius inhibere monstratum est.