Lesinurad (RDEA 594) CAS 878672-00-5 Puritas >99.5% (HPLC)

Description:

Chemical Name: Lesinurad

Synonyma: RDEA 594;Zurampic

CAS: 878672-00-5

Puritas: >99.5% (HPLC)

Pertentare: 98.0~ 102.0%

Aspectus: Alba ad Off-White pulveris

Contactus: Dr

Mobile/Wechat/Whatsapp: +86-15026746401

E-Mail: alvin@ruifuchem.com


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Descriptio:

Shanghai Ruifu Chemical Co., Ltd. est primarius fabrica Lesinurad (RDEA 594) (CAS: 878672-00-5) magna qualitate.Ruifu Chemical traditio totius terrarum, quantitatis competitive pretium, optimum servitium, parvas et moles in promptu habere potest.Purchase Lesinurad et intermedia,Please contact: alvin@ruifuchem.com

Lesinurad Intermedia:

Chemical Properties:

Nomen chemicum Lesinurad
Synonyma 2-[[5-Bromo-4-(4-Cyclopropylnaphthalen-1-yl)-4H-1,2,4-Triazol-3-yl]thio] Acidulum aceticum;2-[[5-Bromo-4-(4-Cyclopropyl-1-Naphthalenyl)-4H-1,2,4-Triazol-3-yl]thio]-Acidum aceticum;RDEA 594;RDEA-594;RDEA594;Zurampic
Stock Status In Stock, Commercial Productio
CAS Number 878672-00-5
Formulae hypotheticae C17H14BrN3O2S
M. Pondus 404.28 g/mol
Liquescens punctum >171℃(dec.)
Density 1.72±0.10 g/cm3
COA & MSDS Praesto
Origin Shanghai, China
Brand Ruifu Chemical

Specifications:

Items Signa inspectionis Proventus
Aspectus Alba ad Off-White pulveris Off-Pulvis alba
Lepidium sativum Retentione temporis maioris apicem solutionis sample respondet relationi vexillum Obsequitur
Aquae Caroli Fischer <0.50% 0.14%
Residere in Ignition <0.10% 0.04%
Metalla gravia (Pb) ≤10ppm <10ppm
Substantiae cognatae (HPLC)    
Maximae impudicitiae <0.20% 0.07%
Totalis immunditias <1.00% 0.24%
Puritas / Analysis Methodus >99.5% (HPLC Area) 99.76%
Assay 98.0~ 102.0% 99.6%
Infrared Imaginis Conformat ut Structure Obsequitur
NMR Imaginum Conformat ut Structure Obsequitur
conclusio Productum probatum est et cum datis specificationibus obsequitur

Sarcina / at /naviportans:

Sarcina:Utrem, aluminium foil, sacculum, 25kg/cardboard Drum, vel secundum exigentiam emptoris.
Repono Condition:Continentem arcte clausam et in loco frigido, sicco (2~8℃) reponunt et a cellis bene ventilatis ab substantiis incompossibilibus.A luce et humore protege.
Naviportans:Libera ad mundum ab aere, per FedEx / DHL Express.Ieiunium et certas traditiones provide.

commoda:

Satis capacitas: sufficientes facilities et technici

Professional Service: One stop acquireing service

Altera Package: Custom sarcina ac titulus praesto

Ieiunium Delivery: Si intra stirpem, tres dies partus praestatur

Supple firmum: Esse rationabile stirpe

Technical Support: Technology solution praesto

Custom Synthesis Service: Range from P. to kilos

High Quality: Constitutus ratio completa qualitas certitudinis

FAQ:

Quam mercari?Quaeso contactumDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 

15 Years Experience?Plus quam XV annos experientiae habemus in fabricando et exportando amplis intermediis pharmaceuticis vel alchimicis pharmaceuticis amplis.

Mercatus principalis?Vendere mercatum domesticum, Americam septentrionalem, Europam, Indiam, Coream, Iaponicam, Australiam etc.

Commodi?Superior qualitas, parabilis pretium, officia professionalia et subsidia technica, ieiunium partus.

Qualitasfides?Qualitas strictioris temperantiae ratio.Pro instrumento analysi professionali includuntur NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Claritas, Solubilitas, Microbialis limes test, etc.

Exempla?Pleraque producta praebent exempla gratuita pro qualitate aestimationis, sumptus naviculas a clientibus solvendos.

Factory Audit?Factory audit gratissimum.Quaeso ante constitutum.

MOQ?Nec MOQ.Parvus ordo placet.

Tempus adferendi? Si intus prosapia, tres dies partus praestatur.

Transportatio?Per Express (FedEx, DHL), ab Air, per Mare.

Documenta?Post servitium venditionis: COA, MOA, ROS, MSDS, etc. praeberi possunt.

Consuetudo Synthesis?Consuetudo synthesis officia praebere potest ad optimas investigationes tuas necessitates aptandas.

Pensio conditio?Proforma cautionis primum post confirmationem ordinis mittetur, informationes nostrae ripae inclusas.Payment by T/T (Telex Transfer), PayPal, Western Union, etc.

878672-00-5 - Introductio:

Lesinurad (RDEA 594) (CAS: 878672-00-5) probatus est ab administratione US Cibus et medicamentis (FDA) die 22 Decembris 2015 probatus est ac deinde ab Agency Medicinae Europaeae (EMA) die 18 Februarii 2016. composita ante ab Ardea evoluta est.AstraZeneca societatem in MMXII acquisivit, quae productum rursus acquisivit.Medicamentum nomen artis Zurampic® in Civitatibus Foederatis et Unione Europaea est.Lesinurad est primus transportator probator mundi urate reuptake (URAT1) inhibitor, coniunctus cum xanthino oxidase inhibitores ut podagram hyperuricemia relatas tractant.

878672-00-5 - Mechanismus Actionis

Lesinurad, nomen artis Zurampic.Lesinurad in compositione cum inhibitore xanthine oxidasi (XOI) pro syndrome podagrae hyperuricemica.Eius mechanismus actionis est adiuvare renes acidum uricum excretum et functionem transportantium in reabsorptione in renibus uric acidorum inhibito operatur.

878672-00-5 - In Vitro Studiorum:

Lesinuradus acidum uricum inhibet activitatem onerariam (IC50=3.36 μM) hURAT1 (humani URAT1), quod plusquam XX vicibus effectum inhibitorium in rURAT1 (rat URAT1) (IC50=74.84 μM).Lesinurad inhibent hURAT1 per commercium clavis amino acid residuum Phe365.

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