N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1 Purity >99.0% (HPLC)

Description:

Nomen chemicum: N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine

CAS: 162012-67-1

Puritas: >99.0% (HPLC)

Aspectus: lux Yellow ad Yellow pulverem

Afatinib Dimaleate (CAS: 850140-73-7)

E-Mail: alvin@ruifuchem.com

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Product Detail

Product Tags

Descriptio:

Ruifu Chemical Supple intermedia de Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
acetaldehyda Diethyl acetalis CAS 3616-56-6
trans-4-dimethylaminocrotonic Acidum hydrochloridum CAS 848133-35-75
Diethylphosphonoaceticum acidum CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-one CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl) -7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineCAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineCAS 314771-88-5

Chemical Properties:

Nomen chemicum	N-(3-Chloro-4-Fluorophenyl)
Synonyma	N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitro-4-Quinazolinamine;(3-Chloro-4-Fluorophenyl)(7-Fluoro-6-Nitroquinazolin-4-yl)amine;4-(3-Chloro-4-Fluoroanilino)-7-Fluoro-6-Nitroquinazolino;Afatinib medium A
CAS Number	162012-67-1
CATTUS Number	RF-PI2026
Stock Status	In Stock, Productio Ascendite ad Tons
Formulae hypotheticae	C14H7ClF2N4O2
M. Pondus	336.68
Sensibilitas	Aer Sensitivus, calor Sensitivus
Liquescens punctum	242.0~ 244.0℃
Ferveret	489℃
Density	1.616
Brand	Ruifu Chemical

Specifications:

Item	Specifications
Aspectus	Lux Yellow ad Yellow pulverem
Puritas / Analysis Methodus	>99.0% (HPLC)
Damnum in Siccatio	<0.50%
Residere in Ignition	<0.20%
Substantiae cognatae
Individual Impurity	<0.50%
Totalis immunditias	<1.00%
Metalla gravis	≤20ppm
Infrared Imaginis	Conformat ut Structure
Proton NMR Spectrum	Conformat ut Structure
Test Standard	Enterprise Standard
Consuetudinem	Afatinib Dimaleate (CAS: 850140-73-7)

Sarcina & Repono:

sarcina: Utrem, aluminium foil, sacculum, 25kg/cardboard Drum, vel secundum exigentiam emptoris

Repono Condition:Repone in vasis signatis in loco frigido et sicco;Protege a lumine et humore

commoda:

FAQ:

Applicatio:

N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine (CAS: 162012-67-1) medium est in synthesi Afatinib Dimaleate (CAS: 850140-73-7); .Afatinib Dimaleate eft salis forma Afatinib.Afatinib est secunda generatio, viva voce administrata, inhibitor irreversibilis familiae tyrosinae kinasium ErbB.Mechanismus actionis Afatinib downregulat ErbB significans per covalenter ligare kinasas ditiones incrementi epidermalis factoris receptoris (EGFR), factor incrementi humani epidermalis receptoris (ER) 2 et HER4, in inhibitione tyrosini kinasi autophosphorylatione irreversibili resultans;vetat etiam transphosphorylationem HER3.Afatinib sicut monotherapia approbatur ad tractationem EGFR tyrosini kinasi inhibitoris (TKI) adulti -sini cum progressu locali seu DefinitionChEBI: Sal maleatum iungendo afatinib cum duobus adaequationibus molaris acidi maleici.Usus primae lineae curationis aegrorum cum cancro metastatico cellae pulmonis non parvae.