Palonosetron Hydrochloridum CAS 135729-62-3 Puritas >99.0% (HPLC) (T) API Factory

Description:

Nomen chemicum: Palonosetron hydrochloridum

CAS: 135729-62-3

Aspectus: Alba vel Off-White Crystalline pulveris

Puritas: >99.0% (HPLC) (T)

Palonosetron hydrochloridum valde potentem, selectivum et oretenus activum 5-HT3 receptor contrarius usus est in praeventionis et curatione chemotherapy-inducti nausea et vomitus (CINV).Antiemetic.

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Product Detail

Product Tags

Descriptio:

Commercial Supple Palonosetron Hydrochloride et intermedia Related:
(S) 1,2,3,4-Tetrahydro-1-Naphthoicum Acidum CAS: 85977-52-2.
(R) 1,2,3,4-Tetrahedro-1-Naphthoicum Acidum CAS: 23357-47-3
(S) -3-Aminoquinuclidine Dihydrochloride CAS: 119904-90-4
3-Quinuclidinonis Hydrochloridis CAS: 1193-65-3
1-Naphthoicum Acidum CAS: 86-55-5
Palonosetron Hydrochloridum CAS: 135729-62-3 API

Chemical Properties:

Nomen chemicum	Palonosetron Hydrochloridum
Synonyma	Palonosetron HCl;(S,S) -Palonosetron Hydrochloridum;RS-25259;RS25259 197;(S)-2-((S)-Quinuclidin-3-yl)-2,3,3a,4,5,6-Hexahydro-1H-Benzo[de]isoquinolin-1-one Hydrochloride;(3aS)-2-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,3a,4,5,6-Hexahydro-1H-benz[de]isoquinolin-1-one Hydrochloride ;Aloxi;Onicit
CAS Number	135729-62-3
CATTUS Number	RF-API03
Stock Status	In Stock, Productio Ascendite ad Tons
Formulae hypotheticae	C19H24N2O·HCl
M. Pondus	332.87
Conditio vitare	Calor Sensitiva
Liquescens punctum	307℃ (dec.)
Solubilitas in aqua	Omnino solutum in aqua
Solubilitas	Leviter solutum in Ethanol
Shipping Temperature	Ambientium, temperatus
COA & MSDS	Praesto
Brand	Ruifu Chemical

Specifications:

Item	Specifications
Aspectus	Alba vel Off-White Crystalline pulveris
Palonosetron Hydrochloridum	>99.0% (HPLC) (T)
Imprimis rotationis [α]20/D	-98.0°～-104.0°
Lepidium sativum	Add BiI7K4， Generate Aureum Yellow Praecipitatum
Lepidium sativum	TLC consistent cum substantia Reference
Lepidium sativum	IR. Congruunt cum Latin IR
Lepidium sativum	Lepidium sativum ut Chloride
Solubilitas	Gratis solutum in aqua, parce solutum in Methanolo, leviter solutum in ethanolo, in acetono solubile.
Solutio in claritate et colore	Maximilianus.Yellow No. 2 Standard Color SOLUTIO
pH Vaule	4.5~6.5 (10mg/ml)
Substantiae Related
Related Compone A (NO)	<0.10%
Related Compone B (Ene-NO)	<0.10%
Related Compone C (S, R)	<0.10%
Related Compone D (R, S)	<0.50%
Palonosetron Enantiomer	<0.10%
Related Compone E (3-Ene)	<0.50%
Impuritas una non specificata	<0.10%
RELICTUM Solvents
Ethanol	<3000ppm
Tetrahydrofuran	<5000ppm
DMF	<880ppm
Normalis Hexane	<290ppm
Methyl Sin	<3000ppm
Isopropanol	<5000ppm
Methylbenzene	<890ppm
Aqua	<0.30%
Residere in Ignition	<0.20%
Damnum in Siccatio	<1.00%
Metalla gravis	<10ppm
Test Standard	Pharmacopoeia Civitatum Foederatarum (USP);Pharmacopoeia Europaea (EP)
Consuetudinem	Palonosetron Hydrochloride API;5-HT3 adversario;CINV

Sarcina & Repono:

sarcina: Utrem, Cardboard Drum, 25kg/Drum, vel secundum exigentiam emptoris.

Repono:Repone in vasis signatis in loco frigido et sicco;Protege a lumine, humore et pestis infestatione.

commoda:

FAQ:

Applicatio:

Palonosetron hydrochloridum (CAS: 135729-62-3) medicamentum est ad nauseam et vomitum inhibendum, quod novum genus est valde selectivum, summus affinitatis receptor 5-HT3, qui vomitum reflexum centrum peripheralium neuronum presynapticum 5-HT impedire potest.Receptor incitationis systematis nervosi centralis directe afficit in 5-HT.Impetus receptoris concitationis generatae per partes nervi vagalis afferentis post aream, claudebant terminationes vagi in ventrem, ne signa ad 5-HT.Receptor felis zonam incidentiam nauseam et vomitum reducere potest.Centralis amet ad curationem chemotherapy emetogenicam acrem acrem inductum, nauseam et vomitum differri.Propter altitudinem curativam effectus, parum latus effectus, longa dimidia vita (circiter 40 h), parva dosis, et sic porro, multum attendit.

Cum 1,2,3,4-Tetrahydro-1-Naphthoico Acidum ut materia principii, scissura, aminatio, reductione, cyclizatio, sal palonosetron hydrochloridi granisetron.Studia clinica demonstraverunt palonosetron tuto adhiberi posse cum corticosteroideis, analgesicis, antiemeticis, antispasmodicis et anticholinergicis medicamentis initio materiae, scissurae, aminationis, reductionis, cyclizationis, sal palonosetron hydrochloridi granisetron.