(R)-(-)-3-Pyrrolidinolum Hydrochloridum CAS 104706-47-0 Puritas ≥99.7% (GC) Puritas Chiral ≥99.7% Panipenem et Darifenacin hydrobromide media
Manufacturer Supple;Princeps munditiae et auctor pretium
Shanghai Ruifu Chemical Co., Ltd. Commercial Supple Chiral Composita:
(R)-(-)-3-Pyrrolidinolum Hydrochloridum CAS: 104706-47-0
(S) -3-hydroxypyrrolidinum hydrochloridum CAS: 122536-94-1
Medium Panipenem (CAS 87726-17-8) et Darifenacin hydrobromide (CAS 133099-07-7)
| Nomen chemicum | (R)-(-)-3-Pyrrolidinolum Hydrochloridum |
| Synonyma | (R)-(-)-3-Hydroxypyrrolidine Hydrochloride;(R)-(-)-3-Hydroxypyrrolidine-HCl |
| CAS Number | 104706-47-0 |
| CATTUS Number | RF-CC102 |
| Puritas / Analysis Methodus | ≥98.0% (GC) |
| Stock Status | In Stock, Productio Ascendite ad Tons |
| Formulae hypotheticae | C4H10ClNO |
| M. Pondus | 123.58 |
| Liquescens punctum | 107.0 ~ 111.0 °C |
| Solubilitas in aqua | Prope diaphanum |
| Brand | Ruifu Chemical |
| Item | Specifications |
| Aspectus | Off-White ad Palestrina Brown Crystalline pulveris |
| Puritas / Analysis Methodus | ≥99.7% (GC) |
| Chiral Puritas | ≥99.7% ee |
| Residere in Ignition | ≤0.50% |
| Imprimis Rotationes [α]D20 | -6.5°~ -8.5° (C=3.5 CH3OH) |
| Omnis immunditia | ≤0.20% |
| Summa immunditiae | ≤0.30% |
| Test Standard | Enterprise Standard |
| Consuetudinem | Pharmaceutical Intermedia;Chiral Composita |
Analysis Methodus
Eqiupment: Instrumentum GC (Shimadzu GC-2010)
Columna: DB-17 Agilent 30mX0.53mmX1.0μm
Clibano temperatus initialis: 80℃
Initial time 2.0min
Rate 15℃/min
Clibano temperatus finalis: 250℃
Final tempus 20min
Portitorem gas Nitrogen
Modus Constans fluxus
Fluere 5.0mL/min
Split ratio 10:1
Injector temperatus: 250℃
Detector temperatus: 300℃
Iniectio volumen 1.0μL
Cavendi sunt ante analysis:
1. Conditio columnae ad 240℃ pro minimis 30minutis.
2. clysterem lava et liner injectoris munda proprie ad contaminantes analyseos priorum removendos.
3. Lava, sicca et dilue in clystere imple phialas lava.
Praeparatio diluens;
Praeparet 2% w/v solutionem sodium hydroxidum in aqua.
Praeparatio sacra:
Expende circa 100mg of (R) hydroxyprrolidinum hydrochloridi-3-vexillum in phialam, 1mL diluentium et dissolve adde.
Praeparatio Test:
Expende circa 100mg specimen experimenti in phialam, adde 1mL diluentium et dissolve.Para in du- plici.
De modo procedendi:
Inject blank (diluente), vexillum praeparatio et probatio super conditionibus GC utens.Neglegere iugis debitum ad blank.Retentionis tempus apicem propter (R) -3-hydroxyprrolidine circiter 5.0min est.
Nota:
Referre effectus in medium
sarcina: Utrem, aluminium foil, pera, cardboard tympanum, 25kg/Drum, vel secundum exigentiam emptoris.
Repono Condition:Repone in vasis signatis in loco frigido et sicco;Protege a lumine, humore et pestis infestatione.
Shanghai Ruifu Chemical Co., Ltd. est primarium fabricae et elit (R)-(-)-3-Pyrrolidinol hydrochloridi (CAS: 104706-47-0) magna qualitate, late in synthesi organica adhibita, synthesis intermediorum pharmaceuticorum and Active Pharmaceutical Ingredient (API) synthesis.
(R)-(-)-3-Pyrrolidinolum Hydrochloridum (CAS: 104706-47-0) medium est typice in synthesi Panipenem (CAS 87726-17-8) et Darifenacin hydrobromide (CAS 133099-07-7).
(R)-(-)-3-pyrrolidinolum hydrochloridum (CAS: 104706-47-0) est hydroxy chiralis derivativa pyrrlodine adhibita in compositionibus activis niologice praeparandis chiralis, sicut receptor muscarinicus antagonistarum et agentium antimicrobialium.
Iter Synthesis (R) -3-hydroxypyrrolidine hydrochloridis
(R) -4-chloro-3-hydroxybutanitrile cum trimethylo chlorosilano in dichloromethano solvendo portatum est ad obtinendum (R) -4-chloro-3-trimethylsiloxy butanitrile.(R) -4-chloro-3-trimethylsiloxyebutylamine tunc in catalyst Pd/C hydrogenatum erat.Denique productum hydroxypyrrolidinum -3-hydroxypyrrolidinum consecutum est a contracto curationis acidi hydrochlorici et coetus tutelae trimethylsilyl remotus est.
