Rivastigmine Tartrate CAS 129101-54-8
Shanghai Ruifu Chemical Co., Ltd. est primarium opificem Rivastigmine Tartrate (CAS: 129101-54-8) cum qualitate alta.Ruifu Chemical traditio totius terrarum, quantitatis competitive pretium, optimum servitium, parvas et moles in promptu habere potest.Purchase Rivastigmine Tartrate,Please contact: alvin@ruifuchem.com
| Nomen chemicum | Rivastigmine Tartrate |
| Synonyma | Exelon;ENA-713;Rivastigmine L-Tartrate;Rivastigmine Hydrogen Tartrate;CS-118;S-Rivastigmine Tartrate;3-[(S)-1-(Dimethylamino)ethyl]phenyl N-ethyl-N-Methylcarbamate L-Tartrate;N-Ethyl-N-Methylcarbamic Acidum 3-[(S)-1-(Dimethylamino)ethyl]phenyl Ester L-Tartrate |
| Stock Status | In Stock, Commercial Productio |
| CAS Number | 129101-54-8 |
| Related CAS | 123441-03-2 |
| Formulae hypotheticae | C14H22N2O2·C4H6O6 |
| M. Pondus | 400.43 g/mol |
| Liquescens punctum | 124.0 ad 128.0℃ |
| Imprimis Rotationes [a]20/D | +4.0° ad +7.0° (C=5, Methanol) |
| Solubilitas | Solutum in Methanol |
| COA & MSDS | Praesto |
| Origin | Shanghai, China |
| Brand | Ruifu Chemical |
| Items | Signa inspectionis | Proventus |
| Aspectus | Alba ad Off-White Crystalline pulveris | Obsequitur |
| Assay | 98.0~ 102.0% (on the anhydrous Basis) | 99.8% |
| Aquae Caroli Fischer | ≤0.50% | 0.15% |
| Residere in Ignition | ≤0.10% | 0.07% |
| Metalla gravia (Pb) | ≤20ppm | <10ppm |
| Phenol immunditia | ≤0.30% | <0.30% |
| DPTTA | ≤0.15% | <0.15% |
| neque immunditia | ≤0.15% | <0.15% |
| Carbamate immunditia | ≤0.15% | <0.15% |
| aut immunditia | ≤0.15% | <0.15% |
| Alia immunditia | ≤0.10% | <0.10% |
| Summa immunditiae | ≤0.50% | <0.50% |
| R-Enantiomer | ≤0.30% | <0.30% |
| Infrared Imaginis | Congruunt Structure | Obsequitur |
| 1H NMR Imaginum | Congruunt Structure | Obsequitur |
| conclusio | Productum probatum est et obtemperat cum USP35 Standard | |
Sarcina:Fluorinated Utrem, aluminium ffoyle, 25kg/cardboard Drum, vel secundum exigentiam emptoris.
Repono Condition:Continentem arcte clausam et in loco frigido, sicco (2~8℃) reponunt et a cellis bene ventilatis ab substantiis incompossibilibus.A luce et humore protege.
Naviportans:Libera ad mundum ab aere, per FedEx / DHL Express.Ieiunium et certas traditiones provide.
Rivastigmine Tartrate
C14H22N2O2·C4H6O6 400.42
Acidum ethylmethylcarbamic, 3-[(S)-1-(dimethylamino)ethyl]phenyl ester, (2R,3R)-2,3-dihydroxybutanedioate;
(S) -3-[1-(Dimethylamino)ethyl]phenyl ethylmethylcarbamate, hydrogenii tartrate [129101-54-8].
Rivastigmine 250.34 [123441-03-2].
DEFINITIO
Rivastigmine Tartrate continet NLT 98.0% et NMT 102.0% intitulatum quantitatem C14H22N2O2·C4H6O6, calculi anhydrosi calculi.
IDENTIFICATIO
• A. Absorptio infrared <197K>
• B. Retentionis tempus solutionis maioris cacuminis Sample respondet solutioni convenientiae Systemati, prout in probatio immunitatum organicarum habetur, Procedure 2: Puritas Enantiomeric.
TEMPTATIO
• De modo procedendi
Quiddam: 8.6 mg/mL ammonium monobasicum phosphatum.Adpone cum solutione ammoniaci ad pH 7.0.
Mobile phase: Methanol, acetonitrile et Buffer (15:15:70)
Solutio aptabilitas systematis: 0.05 mg/mL uterque USP Rivastigmine affinis Compositus A RS et USP Rivastigmine affinis Compositus B RS in tempore Mobili
Solutio Standard: 0.2 mg/mL de USP Rivastigmine Tartrate RS in Mobili phase .
Sample solutio: 0.2 mg/mL de Rivastigmine Tartrate in Mobili phase .
Systema chromatographicum
(Vide Chromatographiam <621>, Ratio idoneitatis.)
Modus: LC
Detector: UV 215 nm
Columna: 4.6-mm × 25-cm;5-µm stipare L7
Fluunt rate: 1.2 mL/min
Iniectio amplitudo: 20 µL
[Nota-Ratio fluxus potest ad 1.5 mL/min accommodari, si opus fuerit, ad retentionis tempus in rivastigmine circa 10 min.]
Ratio convenientia
Exempla: Ratio idoneitatis solutionis et solutionis Standardi
Convenientia requisita
Resolutio: NLT 1.5 inter rivastigmines relatos compositos A et rivastigmines relatos compositi B, Ratio solutionis idoneitatis
Columnae efficientia: NLT 5000 laminae theoreticae, solutiones Standard
Tendens factor: NMT 3.0, Standard solution
Relativum vexillum declinationis: NMT 2.0%, solutionem Latin
Analysis
Exempla: Standard solution et Sample solutionem
Recipis C14H22N2O2·C4H6O6 in portione Rivastigmini Tartrati desumpta:
Proventus = (rU/rS) (CS/CU) 100
rU = apicem responsio ex Sample solutione
rS = apicem responsio ex solutione Latin
CS = retrahitur solutionis Standard (mg/mL)
CU = retrahitur Sample solutionis (mg/mL)
Criteria acceptationis: 98.0%-102.0% super anhydrous basi
IMPURITIES
Inorganic immunditias
• Residuum in Ignitione <281>: NMT 0.1%
• Metalla gravia, Methodus II <231>: NMT 20 ppm .
Impurities organica
• De modo procedendi 1
Mobile Phase et Ratio idoneitatis solutio: Perge ut directum in Pera.
Solutio Standard: 1.0 µg/mL of USP Rivastigmine Tartrate RS in tempore Mobili
Sample solutio: 1.0 mg/mL de Rivastigmine Tartrate in Mobili phase .
Systema chromatographicum: Perge uti in Perge.
(Vide Chromatographiam <621>, Ratio idoneitatis.)
Ratio convenientia
Exempla: Ratio idoneitatis solutionis et solutionis Standardi
Convenientia requisita
Resolutio: NLT 1.5 inter rivastigmines relatos compositos A et rivastigmines relatos compositi B, Ratio solutionis idoneitatis
Relativum vexillum declinationis: NMT 10%, Standard solution
Analysis [Nota-Procursus tempus est 8 temporum retentionis tempus cacuminis rivastigminis.]
Exempla: Standard solution et Sample solutionem
Computus recipis cujuslibet immunditiae in portione Rivastigmine Tartrate sumpta;
Proventus = (rU/rS) (CS/CU) (1/F) 100
rU = cacumen responsionis pro qualibet immunditia ex solutione Sample
rS = apicem responsio ex solutione Latin
CS = intentio USP Rivastigminis Tartrate RS in solutione Standard (mg/mL)
CU = intentio Rivastigminis Tartrati in solutione Sample (mg/mL)
F = responsio relativa factor (vide Tabula immunditia 1)
Criteria acceptatio
Individua Impudicitia: Vide Mensam Impuritas 1 .
Totalis immunditiae: NMT 0.5%
De immunitate Tabula 1
| Nomen | Relativum Retentionis Tempus | Relativum Responsum Factor | Acceptatio Criteria NMT % |
| Tartrate | 0.18 | - | Neglegere |
| Phenol impuritya | 0.28 | 1.6 | 0.3 |
| DPTTAb | 0.46 | 0.83 | 0.15 |
| neque immunditia | 0.57 | 1.2 | 0.15 |
| Rivastigmine | 1.0 | 1.0 | - |
| Carbamate immundus | 4.1 | 1.3 | 0.15 |
| aut immunditia | 6.5 | 1.4 | 0.15 |
| Alia immunditia | - | 1.0 | 0.1 |
a(S)-3-[1-(Dimethylamino)ethyl]phenol.
b (+) -Di-(p-toluoyl)-d-acidi tartarici (rivastigmine affinis compositi A).
c (S) -3-[1-(Dimethylamino)ethyl]phenyl dimethylcarbamatum (rivastigmine affinis compositi B).
d 3-Nitrophenyl ethyl (methyl) carbamatum.
e (S)-N,N-Dimethyl-1-[3-(4-nitrophenoxy)phenyl]ethanamine.
• De modo procedendi 2: Enantiomeric puritas
Quiddam: Translatio 1.78 g sodii phosphatis dihydratorum dibasici et 1.38 g phosphas natrii monobasici in lagulam voluminis 1000-mL.Dissolve et dilue aqua ad volumen.Adpone cum acido phosphorico ad pH 6.0.
Mobilis pars: Translatio 20 mL ex acetonitrili et 205 µL ipsius N, N-dimethyloctylamini ad 1000-mL lagona voluminis, et cum Buffer ad volumen dilutum.
Solutio Standard: 0.1 µg/mL of USP Rivastigmine Tartrate R-Isomer RS in tempore Mobili
Solutio sensibilitatis: 0.05 µg/mL USP Rivastigmine Tartrate R-Isomer RS in periodo Mobili, solutio Latin
Systema idoneitatis solutionis: 100 µg/mL USP Rivastigminis Tartrate RS et 0.1 µg/mL USP Rivastigmine Tartrate R-Isomer RS in periodo Mobili.
Sample solutio: 100 μg/mL de Rivastigmine Tartrati in tempore Mobili
Systema chromatographicum
(Vide Chromatographiam <621>, Ratio idoneitatis.)
Modus: LC
Detector: UV 200 nm
Columna: 4.0-mm × 10-cm;stipare L41
Fluunt rate: 0.5 mL/min
Iniectio amplitudo: 20 µL
Ratio convenientia
Exempla: Solutio Standard, solutio sensitiva, solutionis convenientiae ratio
Convenientia requisita
Resolutio: NLT 0.8 inter cacumina enantiomer, solutionis ratio convenientia
[Note-Elution order is the R-enantiomer, followed by rivastigmine fasti, which is the S-enantiomer.]
Signo-ad-sonitum ratio: NLT 10, Sensitivum solutionis
Relativum vexillum declinationis: NMT 10%, Standard solution
Analysis
Exempla: Standard solution et Sample solutionem
Calculare recipis R-enantiomer in portione Rivastigmine Tartrate capta;
Proventus = (rU/rS) (CS/CU) 100
rU = apicem responsionis R-enantiomer ex solutione Sample
rS = apicem responsionis R-enantiomer ex solutione Standard
CS = intentio R-enantiomeri in solutione Standard (μg/mL)
CU = intentio Rivastigminis Tartrati in solutione Sample (µg/mL)
Acceptatio criteria: NMT 0.3% R-enantiomer
IN SPECIE TESTS
• Determinatio aquae, Methodus Ia <921>: NMT 0.5%
ADDITICIUS REQUISITIS
• Packaging and storage : Conserve in arctis vasis , ac repone ad cella temperiem .
• USP Signa Reference <11>
USP Rivastigmine Tartrate RS
USP Rivastigmine Related Compone A RS
Di-p-toluoyl-d-(+) acidum tartaricum monohydratum.
C20H20O9 404.37
USP Rivastigmine Related Compone B RS
N, N-Dimetylcarbamicum acidum 3-[1-(dimethylamino)ethyl]phenyl ester.
C13H20N2O2 236.32
USP Rivastigmine Tartrate R-Isomer RS
Quam mercari?Quaeso contactumDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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WGK Germania 3
RTECS FA9550000
HS Codex 29242990
Aleam Class 6.1
Stipare Group III
Rivastigmine Tartrate (CAS: 129101-54-8) est tartratum rivastigminis, medicamentum ad curationem morbi Alzheimer.Rivastigmine physostigmine derivativa est, quae primum a Novartis, Helvetia, feliciter explicata est.Nomen artis exelon est, et molecula benzyl carbamate structuram habet, carbamata est inhibitor cholinesterase cerebri-selectivorum, qui acetylcholinesterase et butyrylcholinesterase simul inhibere potest, et cholinergicum conductionem promovere, dum degradationem acetylcholini per cholinergi- nem emissi morando promovent. neurons.Potest operari dysfunctionem cognitivam mediante cholinergico, eo quod effectum cognoscitivum aegrorum cum morbo Alzheimer.Plasma interdum capacitas rivastigminis ligandi infirma est, facilis transitus per claustrum sanguinis cerebri, et gradum selectivity cerebri habet.Non solum selective agere potest in locis vulnerabilibus cortex et hippocampi cerebri, sed etiam praeferentialiter inhibere subtypa dominantium AChE in cerebro, quae cholinergicos effectus peripherales reducere possunt effectus curativos producentes.Vita dimidia pars rivastigmine tartrate in corpore brevis et actio temporis longa est.Dissimilis tacrinam, hoc productum plus inhibendi effectum habet in G1 enzyme in hippocampo et cortex.Amet mitis tractare ad clementiam Alzheimer moderandam, quae suspecta est de morbo Alzheimer vel morbo Alzheimer.
1. Cum acetylcholinesterase inhibitor, rivastigmina bicartrata meliorem effectum musculi succinylcholini relaxantis emendare potest.Ergo opportunum esse debet tempus intermittendi ad sistendum hoc productum ante anesthesiam sumendum.Productum hoc componi debet cum aliis praeparationibus cholinergicis vel anticholinergicis et cautela habenda (videatur.
2. Ob effectus pharmacologicos inhibitores cholinesterasi possunt habere tensionem vagus effectus in corde.Ut cum aliis medicamentis cholinergicis, cautio exercenda est, quando datur aegris syndrome vel aliis scandalo cordis aegrotis (vide Reactiones adversae).
3. Nervus cholinergicus concitatio augeri potest excretionem acidum gastricum.Etsi nullum indicium significantis depravationis respondentium symptomatum in periodo iudicii clinici inventae sunt, aegroti magno periculo ulceris gastrici, quales sunt cum morbo ulceris historia vel cum concomitantibus recipiendis medicamentis anti-inflammatoriis non-steroidalibus; caute utendum est.
4. Sicut alii cholinesterase inhibitores, aegroti cum historia asthmatis vel alii morbi pulmonis impedientes caute utendi sunt.
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