Tacrolimus FK-506 Fujimycin CAS 104987-11-3 API
Manufacturer cum High puritate et stabulo Quality
Nomen chemicum: Tacrolimus
Synonyma: FK-506;Fujimycin
CAS: 104987-11-3
API, High Quality, Commercial Production
Nomen chemicum | Tacrolimus |
Synonyma | FK-506;Fujimycin |
CAS Number | 104987-11-3 |
CATTUS Number | RF-API46 |
Stock Status | In Stock, Productio Ascendite ad Tons |
Formulae hypotheticae | C44H69NO12 |
M. Pondus | 804.02 |
Brand | Ruifu Chemical |
Item | Specifications |
Aspectus | Off-White or Pale Yellow Fine Pulvis, Odourless, Special Gustus |
Lepidium sativum | Positivum sit reactionem |
Claritas | Ad propinquos meos cum Latin |
pH | 5.0~6.0 |
Chloride | ≤0.014% |
Sulphate | ≤0.029% |
Metalla gravia (Pb) | ≤10ppm |
Arsenicum | ≤0.0002% |
Humor (KF) | ≤8.0% |
Residere in Ignition | 18.0%~22.0% |
Assay | ≥72.0% (HPLC, basis exaruit) |
Test Standard | Enterprise Standard |
Consuetudinem | API |
sarcina: Utrem, aluminium foil, pera, cardboard tympanum, 25kg/Drum, vel secundum exigentiam emptoris.
Repono Condition:Repone in vasis signatis in loco frigido et sicco;Protege a lumine, humore et pestis infestatione.
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Tacrolimus (etiam FK-506 vel Fujimycin) medicamentum immunosuppressivum est, cuius principalis usus est post organum traducere ad actionem immunem patientis rationi immunis reducendam et ideo periculum reiectionis organi.Utitur etiam in praeparatione topica in curatione gravi dermatitis atopicae, gravibus refractoriis uveitis post medullam ossis transplantatorum, et conditio cutis vitiligines.Tacrolimus primus extractus est e ius fermentationis Streptomyces tsukuba, terrae microbe in Tsukuba, Iaponia inventa.Nomen tacrolimus derivatur accipiendo 't' pro Tsukuba, nomen montis ubi solo specimen extrahitur, 'acrol' pro macrolide et 'imus' pro immunosuppressant.Tametsi cyclosporin structurae affinia, tacrolimus ostendit simile spectrum effectuum immunosuppressivorum huic agenti in plano celluloso et hypothetico.In studiis initialibus significavit tacrolimus potentem fuisse immunosuppressum, ostendens circa 100 centuplum maiorem in potentia vitro quam cyclosporin in inhibendo T activationem cellularum.Subsequentes in studiis vivorum ostenderunt tacrolimus efficacem esse tum in suppressione spontanea et experimentali morbo autoimmune, tum in praecavendo allografo et xenografo reiectione in exemplaribus animalis organi transplantationis.Initio, tacrolimus adhibitus est pro immunosuppressione systemica aegrorum, qui allografum transplantatio subierant, ut eos prohiberent ne nova insita respuerent.Mox tamen, propter serendipitatem scientiae, animadversum est tacrolimus prosperos eventus in morbis cutaneis in aliquibus aegros transplantandis passos producere posse.Inventio tacrolimus sic ad maiorem cutem pathologiam intelligendam ducit, exempli gratia dermatitis atopic.Postmodum aliae applicationes theologicae tacrolimi delatae sunt et usus huius agentis in dermatologia paulatim dilatatur.
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