Tenofovir Alafenamide Hemifumarate TAF CAS 1392275-56-7 API Factory Anti-HIV Quality
Commercial Supple Tenofovir intermedia:
Tenofovir CAS: 147127-20-6
Tenofovir Disoproxil Fumarate CAS 202138-50-9
Tenofovir Alafenamide Hemifumarate CAS 1392275-56-7
Chloromethyl Isopropyl carbonas CAS 35180-01-9
Diethyl (p-Toluenesulfonyloxymethyl) phosphonatus CAS 31618-90-3
(R)-(+)-Propylene carbonas CAS 16606-55-6
adenine CAS 14047-28-0
Diethyl (Hydroxymethyl) phosphonatus CAS 3084-40-0
Adenine CAS 73-24-5
Nomen chemicum | Tenofovir Alafenamide Hemifumarate |
Synonyma | TAF;GS-7340 Hemifumarate |
CAS Number | 1392275-56-7 |
CATTUS Number | RF-API91 |
Stock Status | In Stock, Productio Ascendite usque ad Centum chiliogrammata |
Formulae hypotheticae | C25H33N6O9P |
M. Pondus | 592.55 |
Repono Temperature | Signatum in siccis, volutpat Temperature |
Brand | Ruifu Chemical |
Item | Specifications |
Aspectus | White to almost Crystals or Crystalline pulveris |
Solubilitas | Dimethylformamide et Methanol;Parce solutum in aqua et THF;Leviter solutum in Acetonitrile et Insolubili in Dichloromethane et Toluene |
Lepidium sativum | IR effusio spectris congruere debet cum reference |
Lepidium sativum B * | Retentio temporis maioris altitudinis exempli solutionis in contenta determinatione chromatogrammi conformis solutionis relationis. |
Lepidium sativum C* | Acidum retentionis fumarici tempus cacuminis maioris in intentione determinationis chromatogrammi conformis ad apicem relationis. |
Aqua Content (per KF) | ≤1.0% |
Solutio in claritate | Plerumque nullae particulae visibiles in 2% (w/v) solutionis methanoli |
Residua solvens | |
Acetonitrile | ≤410ppm |
Ethanol | ≤5000ppm |
Dichloromethane | ≤600ppm |
Toluene | ≤890ppm |
Residere in Ignition | ≤0.10% |
Metalla gravis | ≤20ppm |
Substantiae cognatae | |
PMPA | ≤1.0% |
PMPA Anhydride | ≤0.75% |
Una Phenyl PMPA | ≤1.0% |
Quis non specificatus immunditia | ≤0.15% |
Totalis immunditias | ≤2.0% |
Isomer | ≤1.0% |
Fumaric acid | 9.0% ~ 13.0% (ex anhydrous basis ) |
Microbial limites | |
Summa Aerobic Microbial comitis | ≤1000CFU/g* |
Totalis Yeasts et fingit comes | ≤100CFU/g* |
Mus | Absens |
Assay | 98.0% ~ 102.0% (in anhydrous et soluto-liber basis) |
Test Standard | Enterprise Standard |
sarcina: Utrem, aluminium foil, pera, cardboard tympanum, 25kg/Drum, vel secundum exigentiam emptoris.
Repono Condition:Repone in vasis signatis in loco frigido et sicco;Protege a lumine, humore et pestis infestatione.
Tenofovir Alafenamide Hemifumarate (TAF, GS-7340 hemifumarate), CAS 1392275-56-7, est nucleotide inversa transcriptase inhibitor (NRTIs) et nova prodrug Tenofovir (TFV).Obstruendo transpositionem transcriptase, TAF impedire HIV ne multiplicare et quantitatem HIV in corpore minuere possit.Tenofovir alafenamide est prodrug, quod significat medicamento otiosum esse.In corpore, tenofovir alafenamide convertitur ad diphosphatem Tenofovir (TFV-DP).Tenofovir Alafenamide Fumarate probatus est mense Novembri 2015 pro curatione HIV-1.