3,3′,5-Triiodo-L-Thyronine (Liothyronine; T3) CAS 6893-02-3 Purity >95.0% (HPLC) Factory

Short Description:

Chemical Name: 3,3′,5-Triiodo-L-Thyronine

Synonyms: Liothyronine; Triiodothyronine; T3; L-T3

CAS: 6893-02-3

Purity: >95.0% (HPLC) 

An Odorless, Almost White or Buff Colored Powder

A Potent Thyroid Hormone Receptors TRα and TRβ Agonist 

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com www.ruifuchem.com


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Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of 3,3',5-Triiodo-L-Thyronine (Liothyronine; T3) (CAS: 6893-02-3) with high quality. We can provide COA, worldwide delivery, small and bulk quantities available. If you are interested in this product, please send detailed information includes CAS number, product name, quantity to us. Please contact: alvin@ruifuchem.com

Chemical Properties:

Chemical Name 3,3',5-Triiodo-L-Thyronine  
Synonyms Liothyronine; 3,3,5-Triiodo-L-Thyronine Free Acid; Triiodothyronine; L-Liothyronine; T3; L-T3; Tresitope; L-3,3′,5-Triiodothyronine Free Acid; 3,3',5-Triiodothyronin; O-(4-Hydroxy-3-Iodophenyl)-3,5-Diiodo-L-Tyrosine; HY-A0070A
Impurity  Levothyroxine EP Impurity A
Stock Status In Stock, Production Capacity To Hundreds of Kilograms
CAS Number 6893-02-3 
Molecular Formula C15H12I3NO4 
Molecular Weight 650.98 
Melting Point 234.0~238.0℃(lit.)
Density 2.387g/cm3
Refractive Index 1.763
Sensitive Light Sensitive
Shipping Condition  Ambient Temperatures
Hazard Codes  Xn,Xi,T,F 
Risk Statements 20/21/22-36/37/38-39/23/24/25-23/24/25-11 
Safety Statements 36-26-36/37/39-45-36/37-16 
WGK Germany 
HS Code 29225090
COA & MSDS Available
Brand Ruifu Chemical

Specifications:

Product Name:

Liothyronine  (CAS: 6893-02-3) 

Batch No.:

20131201

Quantity:

15KG

Mfg. Date:

20131227

Expiry Date:

20151226

Date of Report:

20131228

Package:

500G/Bag

Standard

Specifications in House

Item

Specification

Result

Appearance

An Odorless, Almost White or Buff Colored Powder

Pass

Identificaton

The Retention Time of the Major Peak is confirm to the RS

Pass

Solubility

1, Very Slightly Soluble in Water

Pass

2, Disolves in Diluted Aqueous Sodium Hydroxide Solutions

Pass

Specific Rotation

+23.0° ~ +27.0° (C=5 in 1M HCl/EtOH 1:2)

25.3°

Loss on Drying

Not More Than 0.50%

0.29%

Assay (HPLC)

Not More Than 95.0%

99.88%

Levothyroxine

Not More Than 5.00%

Pass

Residual Solvents

1, Chloroform

≤60ppm

Pass

2, Pyridine

≤200ppm

Pass

3, Methanol

≤0.30%

Pass

4, Ethanol

≤0.50%

Pass

5, Acetic Acid

≤0.50%

Pass

Conclusion:

Up to the Standard for Export

Package & Storage:

Package: Bottle, Aluminum foil bag, 25kg/Cardboard Drum, or according to customer's requirement.

Storage Condition: Light Sensitive. Store in sealed containers at cool, dry and ventilated warehouse away from incompatible substances. Protect from light and moisture.

Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock    

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality AssuranceStrict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

SamplesMost products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory AuditFactory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

TransportationBy Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom SynthesisCan provide custom synthesis services to best fit your research needs.

Payment TermsProforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc. 

Application:

3,3',5-Triiodo-L-Thyronine (Liothyronine; T3) (CAS: 6893-02-3) is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively. Liothyronine is a hormone secreted by the thyroid. It is formed by the condensation of L-3-Monoiodotyrosine and L-3.5-Diiodotyrosine. The content in thyroid tissue and blood is far less than that of thyroxine, but its biological activity is 5 to 10 times higher than it. T3 has the effect of promoting material metabolism and energy release; it can also promote growth and development. The normal adult thyroid secretes 30 μg T3 per day, 20% of T3 in plasma comes from the direct secretion of the thyroid, and 80% comes from the transformation of plasma T4 in the periphery. Levothyroxine or L-Thyroxine is a synthetic thyroid hormonethat is chemically identical to thyroxine (T4), which is naturally secreted by the follicular cells of the thyroid gland. It is used to treatthyroid hormone deficiency, and occasionally to prevent the recurrence of thyroid cancer. Like its naturally secreted counterpart, levothyroxine is a chiral compound in the L-form. The related drug dextrothyroxine (D-thyroxine) was used in the past as a treatment for hypercholesterolemia(elevated cholesterol levels) but was withdrawn due to cardiac side effects. Liothyronine is traditionally utilize during cutting, dieting, and/or pre-contest phases of training due to the universal goal of these phases to break down body fat, though in recent years T3 has gained some popularity as a useful agent during bulking and mass gaining phases of training (normally in conjunction with steroids) in order to better efficiently process nutrients and/or to keep body fat levels down during periods of higher caloric intake. Liothyronine is commonly used with steroids due to its significant impact on the body's metabolism as a whole. It is very important to understand that T3 is indiscriminate in its metabolism boosting properties - it will increase the metabolism of fats, carbohydrates, and protein all equally. Therefore, beyond a particular dose of T3, there is an increased risk of muscle loss through increased turnover of protein. Through the use of steroids and a properly adjusted diet, this muscle loss as a result of T3 can be prevented as a result of the nitrogen-retaining and protein sparing properties of the steroids. Liothyronine is also commonly combined with other fat loss agents in order to increase its overall effect, as it does work synergistically with other fat loss agents. 

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