2-Fluoro-5-Formylbenzonitrile CAS 218301-22-5 Purity ≥98.0% Olaparib Intermediate Factory
Te Pure Teitei, Te Hanga Aromoni
Olaparib me nga Takawaenga Paanga:
Olaparib CAS 763113-22-0
2-Fluoro-5-Formylbenzonitrile CAS 218301-22-5
2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)waikawa benzoic CAS 763114-26-7
1-(Cyclopropylcarbonyl)piperazine Hydrochloride CAS 1021298-67-8
3-Oxo-1,3-Dihydroisobenzofuran-1-Ylphosphonic Acid CAS 61260-15-9
| Ingoa matū | 2-Fluoro-5-Formylbenzonitrile |
| Nga kupu taurite | 3-Cyano-4-Fluorobenzaldehyde |
| Tau CAS | 218301-22-5 |
| Tau CAT | RF-PI451 |
| Tūnga Taonga | I roto i te Stock, Production Tauine Up ki Taranata |
| Tātai rāpoi | C8H4FNO |
| Taumaha rāpoi | 149.12 |
| Te Whakarewa | 80.0 ki te 84.0 ℃ (marama) |
| Wairewa | Wairewa ki Methanol |
| Waitohu | Ruifu Chemical |
| Tūemi | Whakatakotoranga |
| Te ahua | Kowhai ki te Paura-ma |
| Maamaa | ≥98.0% |
| makuku (KF) | ≤0.50% |
| Nga poke katoa | ≤2.0% |
| Paerewa Whakamatau | Paerewa hinonga |
| Whakamahinga | Takawaenga o Olaparib (CAS: 763113-22-0) PARP-Inhibitor |
Mōkī: Pounamu, Peeke konumohe konumohe, Paera Kaata, 25kg / Paera, kia rite ranei ki te hiahia a te kaihoko.
Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Tiaki i te marama me te makuku.
Ko te 2-Fluoro-5-Formylbenzonitrile (CAS: 218301-22-5) e whakamahia ana i roto i te whakarite i nga huinga heterocyclic hei aukati PARP mo te whakamahinga hauora.Ka whakamahia te 2-Fluoro-5-Formylbenzonitrile hei takawaenga o Olaparib (CAS: 763113-22-0).Ko Olaparib he aukati ngota ngota iti o PARP1/PARP2 (IC50: 5/1 nM) engari he iti ake te whai hua ki te PARP tankyrase-1 (IC50: 1.5 µM).Ko Olaparib (AZD-2281, ko Lynparza te ingoa hokohoko) he rongoa kua whakamanahia e te FDA mo te mate pukupuku, i whakawhanakehia e KuDOS Pharmaceuticals me muri mai e AstraZeneca.He aukati PARP, he aukati i te poly ADP ribose polymerase (PARP), he whākōkī e whai wāhi ana ki te whakatikatika DNA. Ka pa ki nga mate pukupuku i roto i nga tangata whai whakarerekētanga BRCA1, BRCA2 ranei, kei roto etahi mate pukupuku ovarian, u, prostate.I te Hakihea 2014, i whakaaetia te olaparib mo te whakamahi hei kaihoko kotahi e te EMA me te FDA.Ko te whakaaetanga FDA kei roto mo te germline BRCA mutated (gBRCAm) mate pukupuku ovarian matatau kua whiwhi e toru, neke atu ranei nga rarangi o te chemotherapy.
