2,3,5-Tri-O-benzyl-D-ribonolactone CAS 55094-52-5 Remdesivir Takawaenga COVID-19
Kaihanga Kaihanga Remdesivir me nga Kaiwawao e pa ana ki te Kounga Kairangi
Remdesivir CAS 1809249-37-3
2-Ethyl-1-butanol CAS 97-95-0
Trimethylsilyl Cyanide CAS 7677-24-9
4-Nitrophenol CAS 100-02-7
2-Ethylbutyl ((S)-(perfluorophenoxy)(phenoxy)phosphoryl)-L-alaninate CAS 1911578-98-7
N-[(S)-(4-nitrophenoxy)phenoxyphosphinyl]-L-Alanine 2-ethylbutyl ester CAS 1354823-36-1
(S)-2-Ethylbutyl 2-Aminopropanoate Hydrochloride CAS 946511-97-3
Remdesivir Metabolite (GS-441524) CAS 1191237-69-0
Remdesivir N-2 Takawaenga CAS 1191237-80-5
2,3,5-Tri-O-benzyl-D-ribonolactone CAS 55094-52-5
7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine CAS 937046-98-5
Pyrrolo[1,2-F][1,2,4]Triazin-4-Amine CAS 159326-68-8
4-Amino-7-iodopyrrolo[2,1-f][1,2,4] triazine CAS 1770840-43-1
Ingoa matū | 2,3,5-Tri-O-benzyl-D-ribonolactone |
Nga kupu taurite | 2,3,5-Tri-O-Benzyl-D-Ribono-1,4-Lactone;Remdesivir Intermediate |
Tau CAS | 55094-52-5 |
Tau CAT | RF-PI301 |
Tūnga Taonga | Kei roto i nga taonga, ka eke ki te rau kirokaramu |
Tātai rāpoi | C26H26O5 |
Taumaha rāpoi | 418.49 |
Iwi Whakarewa | 54.0-55.0 ℃ |
Tikanga Rokiroki | Te Pawera o te rūma |
Waitohu | Ruifu Chemical |
Tūemi | Whakatakotoranga |
Te ahua | He kowhai, he ma ranei |
Wairewa | Wairewa i roto i te CH2Cl2 me te Insoluble i H2O |
NMR me MS | Me Whakaae |
Tautuhinga | IR me TLC |
makuku | ≤1.0% |
Te toenga i runga i te mura | ≤0.50% |
Te poke takitahi | ≤0.50% |
Nga Korewa Taamaha | ≤50ppm |
HPLC (210nm) | ≥99.0% |
HPLC (ELSD) | ≥99.0% |
Paerewa Whakamatau | Paerewa hinonga |
Whakamahinga | Takawaenga o Remdesivir (CAS 1809249-37-3) |
Mōkī: Pounamu, Peeke konumohe konumohe, Pahu Kaata, 25kg / Drum, kia rite ranei ki te hiahia a te kaihoko.
Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Whakaorangia mai i te marama, te makuku me te mate kino.
Ko te 2,3,5-Tri-O-benzyl-D-ribonolactone (CAS 55094-52-5) he takawaenga Remdesivir.Ko te Remdesivir (CAS 1809249-37-3) he rongoa antiviral hou i roto i te karaehe o nga tairitenga nucleotide, e whakamahia ana hei rongoa i te COVID-19.Ko te Remdesivir (GS-5734) he kupu whakatairite antiviral nucleoside e aukati ana i te huaketo murine hepatitis (MHV) me te EC50 rite ki te SARS-CoV me te MERS-CoV.Ko nga Coronaviruses (CoVs) he huaketo RNA-a-waa-kotahi, ka pangia e te tini o nga kaihautu kararehe.I roto i te tangata, i mohiohia ko nga CoVs te nuinga o te mate maeke me te pneumonia tae noa ki te putanga mai o te coronavirus mate manawa whakapeka kino (SARS-CoV) i te tau 2002 me te Middle East respiratory syndrome coronavirus (MERS-CoV) i te tau 2012 mai i nga punaha zoonotic.Ko Remdesivir te monophosphoramidate prodrug o te C-adenosine nucleoside analogue GS-441524.I roto i nga pūtau pukupuku roro (DBT) kua pangia e te MHV, ka kaha ake te aukati a GS-5734 i te MHV i te GS-441524, me te GS-5734 EC50 o 0.03 M. I tua atu, i whakatauhia nga uara EC50 i muri i te maimoatanga me te GS-441573 me te GS-441524. i roto i te SARS-CoV- me te MERS-CoV i pangia e nga ahurea tuatahi o te tangata epithelial cell (HAE).