5-(2-Fluorophenyl)-1H-Pyrrole-3-Carbaldehyde CAS 881674-56-2 Vonoprazan Fumarate Intermediate Purity ≥99.0%
Whakaratohia te Vonoprazan Fumarate me te Waenga Takawaenga
5-(2-Fluorophenyl)pyrrole-3-Carboxaldehyde CAS 881674-56-2
Pyridine-3-Sulfonyl Chloride CAS 16133-25-8
Vonoprazan Fumarate (TAK-438) CAS 1260141-27-2 881681-01-2
| Ingoa matū | 5-(2-Fluorophenyl)-1H-Pyrrole-3-Carbaldehyde |
| Nga kupu taurite | Vonoprazan Fumarate (TAK-438) Waenga 3 |
| Tau CAS | 881674-56-2 |
| Tau CAT | RF-PI330 |
| Tūnga Taonga | I roto i te Stock, Production Tauine Up ki Taranata |
| Tātai rāpoi | C11H8FNO |
| Taumaha rāpoi | 189.19 |
| Waitohu | Ruifu Chemical |
| Tūemi | Whakatakotoranga |
| Te ahua | Kowhai ki te Paura Paraone |
| Te Whakarewa | 122.0~131.0 ℃ |
| Tautuhi: RT(HPLC) | Whakaritea ki te Paerewa Tohutoro |
| Ngaronga i te whakamaroke | ≤0.50% |
| Te toenga i te mura | ≤0.50% |
| Nga Taonga Paanga | |
| Maamaa | ≥99.0% |
| Tetahi poke kotahi | ≤0.50% |
| Nga poke katoa | ≤1.0% |
| Paerewa Whakamatau | Paerewa hinonga |
| Whakamahinga | Takawaenga o Vonoprazan Fumarate (TAK-438) (CAS 881681-01-2) |
Mōkī: Pounamu, Peeke konumohe konumohe, Pahu Kaata, 25kg / Drum, kia rite ranei ki te hiahia a te kaihoko.
Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Whakaorangia mai i te marama, te makuku me te mate kino.
Ko te 5-(2-Fluorophenyl)-1H-Pyrrole-3-Carbaldehyde (CAS 881674-56-2) ka mahi hei reagent i roto i te whakarite waihanga o nga pärönaha pyrrole hou hei aukati waikawa-whakataetae (P-CAB).Ko te 5-(2-Fluorophenyl)pyrrole-3-Carboxaldehyde te takawaenga o Vonoprazan Fumarate (CAS 1260141-27-2).Ko te Vonoprazan fumarate (Takecab®), i kitea, i whakawhanakehia e Takeda me Otsuka, i whakaaetia e te PMDA o Hapani i te Hakihea 2014, ka tohuhia mo te maimoatanga o te mate pukupuku, te whewhe duodenal me te reflux esophagitis.Ko te Vonoprazan fumarate he momo mahi hou e kiia nei ko te konupora-whakataetae waikawa aukati, e whakataetae ana te aukati i te herenga o nga katote konupora ki te H+, K+-ATPase (e mohiotia ana ko te papu iraoho) i roto i te taahiraa whakamutunga o te hunanga waikawa pekitīlia i roto i nga pūtau parietal puku.Kaore a Vonoprazan i te aukati i te mahi Na +, K + -ATPase ahakoa i te 500 nga wa teitei ake i o ratou uara IC50 ki nga mahi H +, K + -ATPase pekitīlia.I tua atu, kaore te rongoa e pa ki te ahua huna o te kopu, kaore i rite ki nga PPI.
