5-Fluorocytosine (5-FC) CAS 2022-85-7 Purity ≥99.5% (HPLC) Capecitabine Emtricitabine Intermediate Factory

5-Fluorocytosine (5-FC) CAS: 2022-85-7 Tikanga Tātari
Te ahua-ma, tata ranei te ma te paura tioata
Ngaronga i runga i te whakamaroke-Merohia ki te 105 mo te 4 haora: ka ngaro te taumaha i te 1.50% o tona taumaha.
Te toenga i runga i te mura-kaua e neke ake i te 0.1%.
Nga Koura Nui-kaua e neke ake i te 0.002%.
Fluoride-Whakaranuhia te 70 mL o te otinga pāhare pāporo pūhaumāota hou kua rite ki te 30 mL o te waipiro isopropyl, whakakiia te electrode ki te supernatant marama, me te tuku i te hiko kia noho ki roto i te ranunga kia kaua e iti iho i te 2 haora i mua i te whakamahi, me te pai mo te po.
Ina tango i nga inenga, whakawhitia te otinga ki te ipurau 150-mL, ka rukuhia nga hiko.Whakauruhia he pae whakakorikori kua pania ki te polytef ki roto i te ipurau, whakanohohia te ipurau ki runga i te whakakorikori aukume kua whakamaara te tihi o runga, ka tuku kia oho kia tae ra ano te taurite (tata ki te 1 ki te 2 meneti).Horoi me te whakamaroke i nga hiko i waenga i nga inenga, kia tupato kei rakuraku te karaihe i roto i te hiko katote motuhake.
Inehia te kaha o ia whakaritenga Paerewa, ka tuhi i te kukū o te fluoride, i roto i te mg ia 100 mL, me te kaha, i roto i te mV, ki runga pepa semilogarithmic.Te ine i te kaha o te whakarite Whakamatau, ka whakatau mai i te anau paerewa te kukū o te fluoride, i te mg ia 100 mL.Tātaihia te ōrau o te pūkōwhai i te wāhanga o te Flucytosine i tangohia e te tātai:
C / 10
ko C te kukū o te fluoride, i roto i te mg ia 100 mL, mai i te ānau paerewa: kaua e neke ake i te 0.05% o te fluoride ka kitea.
Fluorouracil-Whakarewa 250 mg ki te 10 mL o te ranunga o te waikawa ahetiki me te wai (4:1).Hoatuhia te 20 µL o tenei otinga ki tetahi pereti chromatographic paparanga angiangi kua pania ki te paparanga 0.5-mm o te ranunga kirikiri kirikiri chromatographic.Ki te pereti kotahi te tono 20 µL, i roto i te 10-µL nga pikinga, o te wairewa 0.025 mg ia mL o USP Fluorouracil RS i roto i te ranunga o te waikawa acetic me te wai (4:1).Whakawhanakehia te chromatogram ki roto i te ranunga o te chloroform me te waikawa acettic glacial (13:7) tae noa ki te neke o te mua whakarewa kia kaua e iti iho i te 14 cm mai i te takenga.Tangohia te pereti mai i te ruuma whakawhanake, ka tuku kia mimiti te whakarewa.Rapua nga waahi i runga i te pereti ma te mataki i raro i te iraruke UV roangaru-poto: ko tetahi waahi mai i te otinga i raro i te whakamatautau kaore i te rahi ake te rahi me te kaha atu i te waahi i te RF i hangaia e te otinga Paerewa, e rite ana ki te kore e neke ake i te 0.1% o fluorouracil.
Whakatau-Whia te 400 mg o te Flucytosine, kua ata paunatia, ki roto i te ipurau 250-mL, whakauruhia te 150 mL o te ranunga o te 2 rōrahi o te waikawa acetic glacial me te 1 rōrahi o te acetic anhydride, ka rewa, ka whakamahana marie ki te tika.Whakawetohia ma te kaha ki te 0.1 N te waikawa perchloric VS, ma te whakamahi i te punaha hiko karaehe-calomel.Whakaritehia he whakatau patea, me te whakatika i nga mea e tika ana.Ko ia mL o te 0.1 N te waikawa perchloric he rite ki te 12.91 mg o C4H4FN3O.Ko te Flucytosine he iti iho i te 98.5 paiheneti, kaua hoki e neke ake i te 101.0 paiheneti o C4H4FN3O, ka tatauhia i runga i te tikanga whakamaroke.