6-O-Methylguanine CAS 20535-83-5 Nelzarabine Intermediate Factory
Whakarato Ki te Maamaa Teitei, Hanganga Aromoni
Ingoa matū: 6-O-Methylguanine
CAS: 20535-83-5
| Ingoa matū | 6-O-Methylguanine |
| Nga kupu taurite | 2-Amino-6-Methoxypurine |
| Tau CAS | 20535-83-5 |
| Tau CAT | RF-PI509 |
| Tūnga Taonga | I roto i te Stock, Production Tauine Up ki Taranata |
| Tātai rāpoi | C6H7N5O |
| Taumaha rāpoi | 165.16 |
| Te Whakarewa | >300℃ (marama) |
| Waitohu | Ruifu Chemical |
| Tūemi | Whakatakotoranga |
| Te ahua | Paura Kiriata-White |
| Tikanga Whakamatau / Tatau | ≥98.5% (HPLC) |
| Ngaronga i te whakamaroke | ≤0.50% |
| Te toenga i runga i te mura | ≤0.50% |
| Nga poke katoa | ≤1.5% |
| Paerewa Whakamatau | Paerewa hinonga |
| Whakamahinga | Takawaenga o Nelzarabine (CAS: 121032-29-9), T-KATOA & T-LBL |
Mōkī: Pounamu, Peeke konumohe konumohe, 25kg / Cardboard Drum, kia rite ranei ki te hiahia a te kaihoko.
Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Tiaki i te marama me te makuku.
Ka taea te whakamahi 6-O-Methylguanine (CAS: 20535-83-5) hei takawaenga i roto i te whakahiato o Nelzarabine (CAS: 121032-29-9).Ko te Nelarabine he prodrug mo te deoxyguanosine analogue-9-beta-D-arabinofuranosyl guanine (ara-G).Nelarabine demethylates i roto i te mahi o te adenosine deaminase (ADA) ka huri hei ara-G.Na GlaxoSmithKline i hanga angitu tuatahi a Nelarabine.I te Oketopa 28, 2005 i raro i te whakaaetanga a te US Food and Drug Administration, ka noho hei rongoa hou mo te rongoa T-cell acute lymphoblastic leukemia (T-ALL) me te T-Cells lymphoblasticlymphoma (T-LBL) e atete ana ki te iti rawa. e rua nga momo tikanga haumanu ka hoki mai i muri i te maimoatanga tuatahi.Ko tenei rongoa hou i whakaingoatia ki te United States i te tau 2006.
