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7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one CAS 160129-45-3 Tolvaptan Intermediate
Kaihanga Kaihanga, Kounga Teitei, Hanganga Aromoni
Tolvaptan me nga Takawaenga Paanga:
Tolvaptan CAS 150683-30-0
7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one CAS 160129-45-3
o-Toluoyl Chloride CAS 933-88-0
4-Amino-2-Methylbenzoic Acid CAS 2486-75-1
2-Methyl-4-Nitrobenzoic Waikawa CAS 1975-51-5
| Ingoa matū | 7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one |
| Nga kupu taurite | 7-Chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one;7-Chloro-3,4-dihydro-1H-benzo[b]azepin-5(2H)-kotahi |
| Tau CAS | 160129-45-3 |
| Tau CAT | RF-PI395 |
| Tūnga Taonga | I roto i te Stock, Production Tauine Up ki Taranata |
| Tātai rāpoi | C10H10ClNO |
| Taumaha rāpoi | 195.65 |
| Te Whakarewa | 103.0 ki te 107.0 ℃ |
| Wairewa | Wairewa ki Methanol |
| Waitohu | Ruifu Chemical |
| Tūemi | Whakatakotoranga |
| Te ahua | Te Kakariki Maama ki te Paura Kowhai Maama |
| Nga Tikanga Tautuhi | NMR, HPLC |
| Te Maama / Tikanga Tatauria | ≥99.0% (HPLC) |
| Ngaronga i te whakamaroke | ≤1.0% |
| Te toenga i runga i te mura | ≤0.50% |
| Tetahi poke kotahi | ≤0.50% |
| Nga poke katoa | ≤1.0% |
| Paerewa Whakamatau | Paerewa hinonga |
| Whakamahinga | Takawaenga o Tolvaptan (CAS 150683-30-0), maimoatanga o Hyponatremia |
Mōkī: Pounamu, Peeke konumohe konumohe, 25kg / Cardboard Drum, kia rite ranei ki te hiahia a te kaihoko.
Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Tiaki i te marama me te makuku.
Ko te 7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one (CAS 160129-45-3) he takawaenga i roto i te whakahiato o Tolvaptan (CAS 150683-30-0).Ko te Tolvaptan he kaikokoti, he whakataetae a-waha korepeptide arginine vasopressin V2 kaikawe kaikawe me te IC50 o 1.28µM mo te aukati i te whakahiato pereti a AVP.Ka whakamahia te Tolvaptan ki te rongoa i te hyponatremia e pa ana ki te ngoikore o te ngakau, te cirrhosis, me te mate o te homoni antidiuretic tika.Kei roto hoki a Tolvaptan i nga whakamatautau haumanu tere mo te mate whatukuhu polycystic.Ko te maimoatanga me te Tolvaptan ka tere me te mau tonu te heke o te taumaha tinana me te piki haere o te whakaputa mimi, te whakapai me te / ranei te whakarite i te konutai serum i roto i nga turoro hyponatremic, ka whakaheke i nga tohu me nga tohu o te popoketanga me te whakanui i te matewai.
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