7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2 Purity >99.0% (HPLC) Afatinib Dimaleate Intermediate Factory

Whakaahuatanga Poto:

Ingoa: 7-Chloro-6-Nitro-4-Hydroxyquinazoline

CAS: 53449-14-2

Maamaa: >99.0% (HPLC)

Te ahua: Kowhai Maama ki te Paura Parauri Maama

Takawaenga o Afatinib Dimaleate (CAS: 850140-73-7)

E-Mail: alvin@ruifuchem.com

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Whakaahuatanga:

Ruifu Chemical Supply Takawaenga o Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino)acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Waikawa Diethylphosphonoacetic CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-kotahi CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineCAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineCAS 314771-88-5

Ngā Āhuatanga matū:

Ingoa matū	7-Chloro-6-Nitro-4-Hydroxyquinazoline
Nga kupu taurite	7-Chloro-4-Hydroxy-6-Nitroquinazoline;7-Chloro-6-Nitro-4-Quinazolinol;7-Chloro-6-Nitro-4-Quinazolinone;7-Chloro-6-Nitro-4(3H)-Quinazolinone;7-Chloro-6-Nitro-3,4-Dihydroquinazolin-4-one;7-Chloro-6-Nitroquinazolin-4(3H)-kotahi
Tau CAS	53449-14-2
Tau CAT	RF-PI2030
Tūnga Taonga	I roto i te Stock, Production Tauine Up ki Taranata
Tātai rāpoi	C8H4ClN3O3
Taumaha rāpoi	225.59
Te tairongo	Te werawera
Wairewa	He iti te whakarewa ki te Dimethylformamide
Waitohu	Ruifu Chemical

Whakatakotoranga:

Tūemi	Whakatakotoranga
Te ahua	Kowhai Maama ki te Paura Parauri Maama
Tautuhi (HPLC)	Te Wa Pupuri Tauira Me Whakaorite ki te Paerewa
Te Maama / Tikanga Tatauria	>99.0% (HPLC)
Iwi Whakarewa	300.0~303.0 ℃
Ihirangi wai (KF)	<0.50%
Te toenga i runga i te mura	<0.30%
poke 1	<0.50% (7-Chloro-4-Hydroxyquinazoline CAS: 31374-18-2)
poke 2	<0.50% (5,7-Dichloro-4[1H]quinazolinone)
poke 3	<1.00% (7-Chloro-8-Nitro-4[1H]quinazolinone)
Ētahi atu poke kotahi	<0.20%
Nga poke katoa	<1.00%
Konga Taamaha (hei Pb)	<20ppm
Spectrum Infrared	He rite ki te Hanganga
Proton NMR Spectrum	Proton NMR Spectrum
Paerewa Whakamatau	Paerewa hinonga
Whakamahinga	Takawaenga o Afatinib, Afatinib Dimaleate

Mōkī me te Rokiroki:

Mōkī: Pounamu, Peeke konumohe konumohe, 25kg / Kaata Drum, kia rite ranei ki te hiahia a te kaihoko

Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Tiaki i te marama me te makuku

Painga:

FAQ:

Taupānga:

Ko te 7-Chloro-6-Nitro-4-Hydroxyquinazoline (CAS: 53449-14-2) he takawaenga o Afatinib Dimaleate (CAS: 850140-73-7).Ko te Afatinib he whanau ErbB e kore e taea te huri hei aukati i te tuku korero me te aukati i nga huarahi nui e uru ana ki te tipu me te wehenga o nga pūtau mate pukupuku.Na te mea ko te tikanga whakawhiti korero a te whanau ErbB ka taea e te maha o nga homodimers me nga heterodimers, ko te aukati i te wa kotahi o te maha o nga mema o te whanau ErbB (penei i te EGFR, HER2, ErbB3 me ErbB4) ka taea te aukati i te whakawhiti korero o raro.Ka whakamahia te Afatinib ki te rongoa i tetahi momo mate pukupuku pūkahukahu (mate pukupuku pūkahukahu kore-iti) kua horapa ki etahi atu wahanga o te tinana.No roto i te karaehe o nga raau taero e mohiotia ana ko te aukati kinase.Ka mahi ma te whakaroa, te aukati ranei i te tipu o nga pūtau mate pukupuku.Ka herea ki tetahi pūmua (epidermal receptor-EGFR) i etahi pukupuku.