7-Fluoro-6-Nitroquinazolin-4(1H)-kotahi CAS 162012-69-3 Purity >99.0% (HPLC) Afatinib Dimaleate Intermediate Factory

Whakaahuatanga Poto:

Ingoa matū: 7-Fluoro-6-Nitroquinazolin-4(1H)-one

CAS: 162012-69-3

Maamaa: >99.0% (HPLC)

Kowhai ki te Whero Kowhai Karaihe, paura ranei

Takawaenga o Afatinib Dimaleate (CAS: 850140-73-7)

Kounga Teitei, Hanganga Aromoni

E-Mail: alvin@ruifuchem.com

Tukuna he imeera ki a matou

Taipitopito Hua

Hua e Pa ana

Tohu Hua

Whakaahuatanga:

Ruifu Chemical Supply Takawaenga o Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino)acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Waikawa Diethylphosphonoacetic CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-kotahi CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineCAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineCAS 314771-88-5

Ngā Āhuatanga matū:

Ingoa matū	7-Fluoro-6-Nitroquinazolin-4(1H)-kotahi
Nga kupu taurite	7-Fluoro-6-Nitroquinazolin-4(3H)-kotahi;7-Fluoro-4-Hydroxy-6-Nitroquinazoline;7-Fluoro-6-Nitroquinazolin-4-ol;7-Fluoro-6-Nitro-4-Hydroxyquinazoline;7-Fluoro-6-Nitro-1H-Quinazolin-4-one
Tau CAS	162012-69-3
Tau CAT	RF-PI2025
Tūnga Taonga	I roto i te Stock, Production Tauine Up ki Taranata
Tātai rāpoi	C8H4FN3O3
Taumaha rāpoi	209.13
Waitohu	Ruifu Chemical

Whakatakotoranga:

Tūemi	Whakatakotoranga
Te ahua	Kowhai ki te Whero Kowhai Karaihe, paura ranei
1 H NMR Spectrum	E rite ana ki te Hanganga
Te Maama / Tikanga Tatauria	>99.0% (HPLC)
Ngaronga i te whakamaroke	<0.50%
Nga poke katoa	<1.00%
Proton NMR Spectrum	He rite ki te Hanganga
Paerewa Whakamatau	Paerewa hinonga
Whakamahinga	Takawaenga o Afatinib Dimaleate (CAS: 850140-73-7)

Mōkī me te Rokiroki:

Mōkī: Pounamu, Peeke konumohe konumohe, 25kg / Kaata Drum, kia rite ranei ki te hiahia a te kaihoko

Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Tiaki i te marama me te makuku

Painga:

FAQ:

Taupānga:

Ko te 7-Fluoro-6-Nitroquinazolin-4(1H)-one (CAS: 162012-69-3) he takawaenga o Afatinib Dimaleate (CAS: 850140-73-7).Ko te Afatinib he whanau ErbB e kore e taea te huri hei aukati i te tuku korero me te aukati i nga huarahi nui e uru ana ki te tipu me te wehenga o nga pūtau mate pukupuku.Na te mea ko te tikanga whakawhiti korero a te whanau ErbB ka taea e te maha o nga homodimers me nga heterodimers, ko te aukati i te wa kotahi o te maha o nga mema o te whanau ErbB (penei i te EGFR, HER2, ErbB3 me ErbB4) ka taea te aukati i te whakawhiti korero o raro.Ko te Afatinib he rongoa kua whakaaetia mo te maimoatanga o te mate pukupuku pukupuku kore-iti (NSCLC), i hangaia e Boehringer Ingelheim.Ka mahi hei aukati angiokinase.Pērā i te lapatinib me te neratinib, ko te afatinib he aukati tyrosine kinase (TKI) e kore e taea te whakakore i te tangata epidermal growth factor receptor 2 (Her2) me te epidermal growth factor receptor (EGFR) kinases.Ko te Afatinib ehara i te kaha ki te whakakorikori i te EGFR e whaaia ana e nga reanga tuatahi o nga TKI likeerlotinib, gefitinib ranei, engari ki te hunga kaore e aro ki enei maimoatanga paerewa.Na tana mahi taapiri ki a Her2, kei te whakatewhatewhahia mo te mate pukupuku uma me etahi atu mate pukupuku EGFR me Her2.